Serum kisspeptin levels along reproductive period in women: is it a marker for aging?

Erel, C. Tamer; Özçivit, İpek Betül; İnan, Deniz; Mut, Ayşegül; Hatipoglu, Burçin Karakus; Konukoğlu, Díldar

doi:10.1080/09513590.2022.2028768

Cited by 4 publications

(4 citation statements)

References 31 publications

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“…KISS was negatively correlated with age, BMI, CRP, and serum leptin level among participants with CF. Serum KISS levels of healthy women were found to be significantly and negatively correlated with age (R = − 0.458) in the study by Erel et al 43 Declined levels of KISS and its receptor in different brain regions with age were also observed in animal studies 44 . Sitticharoon et al revealed that serum KISS was positively correlated with body weight, BMI, and serum leptin in male subjects 31 .…”

Section: Discussionmentioning

confidence: 84%

Serum kisspeptin and proopiomelanocortin in cystic fibrosis: a single study

Galiniak

Podgórski

Rachel

et al. 2022

Sci Rep

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The determination of hormonal biomarkers is of increasing interest in many diseases, including cystic fibrosis (CF). Hormones that have not been estimated and described so far in CF include kisspeptin (KISS) and proopiomelanocortin (POMC), which are involved in the regulation of many processes, including appetite and fertility. Therefore, the aim of our study was to estimate the level of KISS and POMC in sera from CF patients and to determine the correlation between these hormones and clinical parameters. For this purpose, we estimated the levels of KISS and POMC in 38 CF patients and 16 healthy participants with enzyme-linked immunosorbent assay. We found significantly reduced levels of KISS and POMC in people with CF compared to healthy subjects (1.76 ± 0.46 vs. 2.27 ± 0.56 ng/mL, p < 0.05 and 6.25 ± 4.36 vs. 14.74 ± 6.24 ng/mL, p < 0.001, respectively). Furthermore, the level of both hormones was negatively correlated with age. The hormones studied did not correlate with the results of spirometry and each other. Thus, decreased KISS and POMC levels may be associated with lower body weight and delayed puberty in patients with CF.

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Section: Discussionmentioning

confidence: 84%

Serum kisspeptin and proopiomelanocortin in cystic fibrosis: a single study

Galiniak

Podgórski

Rachel

et al. 2022

Sci Rep

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“…Research has revealed that the expression of both kisspeptins and KISS1R is dysregulated with advancing age in various tissues, including the brain and peripheral organs [ 16 , 74 , 78 ]. This age-related decline may contribute to alterations in reproductive function and hormone regulation [ 19 , 70 , 79 , 80 ]. Importantly, the kisspeptin-KISS1R system has been implicated in the regulation of the hypothalamic-pituitary–gonadal axis, which plays a crucial role in the aging process [ 19 , 70 , 79 , 80 ].…”

Section: Discussionmentioning

confidence: 99%

“…This age-related decline may contribute to alterations in reproductive function and hormone regulation [ 19 , 70 , 79 , 80 ]. Importantly, the kisspeptin-KISS1R system has been implicated in the regulation of the hypothalamic-pituitary–gonadal axis, which plays a crucial role in the aging process [ 19 , 70 , 79 , 80 ]. Research has also explored the potential of kisspeptins to modulate inflammatory processes, which hold implications for diverse age-related conditions.…”

Section: Discussionmentioning

confidence: 99%

Role of the kisspeptin-KISS1R axis in the pathogenesis of chronic kidney disease and uremic cardiomyopathy

Dinh,

Kovács,

Kis

et al. 2023

GeroScience

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The prevalence of chronic kidney disease (CKD) is increasing globally, especially in elderly patients. Uremic cardiomyopathy is a common cardiovascular complication of CKD, characterized by left ventricular hypertrophy (LVH), diastolic dysfunction, and fibrosis. Kisspeptins and their receptor, KISS1R, exert a pivotal influence on kidney pathophysiology and modulate age-related pathologies across various organ systems. KISS1R agonists, including kisspeptin-13 (KP-13), hold promise as novel therapeutic agents within age-related biological processes and kidney-related disorders. Our investigation aimed to elucidate the impact of KP-13 on the trajectory of CKD and uremic cardiomyopathy. Male Wistar rats (300–350 g) were randomized into four groups: (I) sham-operated, (II) 5/6 nephrectomy-induced CKD, (III) CKD subjected to a low dose of KP-13 (intraperitoneal 13 µg/day), and (IV) CKD treated with a higher KP-13 dose (intraperitoneal 26 µg/day). Treatments were administered daily from week 3 for 10 days. After 13 weeks, KP-13 increased systemic blood pressure, accentuating diastolic dysfunction’s echocardiographic indicators and intensifying CKD-associated markers such as serum urea levels, glomerular hypertrophy, and tubular dilation. Notably, KP-13 did not exacerbate circulatory uremic toxin levels, renal inflammation, or fibrosis markers. In contrast, the higher KP-13 dose correlated with reduced posterior and anterior wall thickness, coupled with diminished cardiomyocyte cross-sectional areas and concurrent elevation of inflammatory (Il6, Tnf), fibrosis (Col1), and apoptosis markers (Bax/Bcl2) relative to the CKD group. In summary, KP-13’s influence on CKD and uremic cardiomyopathy encompassed heightened blood pressure and potentially activated inflammatory and apoptotic pathways in the left ventricle.

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“…[ 19 ] Erel et al . [ 23 ] indicated that age and serum kisspeptin levels had a substantial and negative correlation ( r = −0.458). Compared to the other age groups over 25 years, the group between 20 and 24 years had the greatest amounts of kisspeptin ( P < 0.001).…”

Section: Discussionmentioning

confidence: 99%

Study of serum level of kisspeptin and interferon-beta in genital wart patients

Eldeen Bazid,

Marae,

Tayel

et al. 2023

Indian J Sex Transm Dis

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Background: Researchers are interested in genital wart (GW) studies due to their increased incidence. In a single experimental research, virally infected mouse models showed elevated kisspeptin levels and low interferon levels. Objective: The objective of the study was to evaluate the serum levels of kisspeptin and interferon (INF)-beta in GW patients. Patients and Methods: Forty patients with GWs and forty healthy participants of comparable age and sex as a control group were included in this case–control study. Serum levels of kisspeptin and IFN-beta were measured using ELISA during the period from December 2021 to April 2022. Results: Kisspeptin was significantly higher among cases than controls, whereas IFN-beta level was lower among cases than controls ( P < 0.001). There were no significant relations between kisspeptin and IFN-beta levels and the clinical data for the studied participants, and there was no significant correlation between both ( P > 0.05). Conclusion: The reported increased kisspeptin level which was associated with decreased interferon-beta level in patients with GWs might indicate a new insight into viral infection pathogenesis. Further research including all steps in kisspeptin/G protein-coupled receptor 54 pathway is required. Targeted therapy for this pathway may be of value for those patients.

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Serum kisspeptin levels along reproductive period in women: is it a marker for aging?

Cited by 4 publications

References 31 publications

Serum kisspeptin and proopiomelanocortin in cystic fibrosis: a single study

Serum kisspeptin and proopiomelanocortin in cystic fibrosis: a single study

Role of the kisspeptin-KISS1R axis in the pathogenesis of chronic kidney disease and uremic cardiomyopathy

Study of serum level of kisspeptin and interferon-beta in genital wart patients

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