Serum kisspeptin and proopiomelanocortin in cystic fibrosis: a single study

Abstract

The determination of hormonal biomarkers is of increasing interest in many diseases, including cystic fibrosis (CF). Hormones that have not been estimated and described so far in CF include kisspeptin (KISS) and proopiomelanocortin (POMC), which are involved in the regulation of many processes, including appetite and fertility. Therefore, the aim of our study was to estimate the level of KISS and POMC in sera from CF patients and to determine the correlation between these hormones and clinical parameters. For this purpose, we estimated the levels of KISS and POMC in 38 CF patients and 16 healthy participants with enzyme-linked immunosorbent assay. We found significantly reduced levels of KISS and POMC in people with CF compared to healthy subjects (1.76 ± 0.46 vs. 2.27 ± 0.56 ng/mL, p < 0.05 and 6.25 ± 4.36 vs. 14.74 ± 6.24 ng/mL, p < 0.001, respectively). Furthermore, the level of both hormones was negatively correlated with age. The hormones studied did not correlate with the results of spirometry and each other. Thus, decreased KISS and POMC levels may be associated with lower body weight and delayed puberty in patients with CF.

The Association of the Hypothalamic-Pituitary-Adrenal Axis with Appetite Regulation in Children with Fetal Alcohol Spectrum Disorders (FASDs)

“…To date, there are only a few reports on the determination of POMC in serum using the immunoenzymatic method. Our recent study in cystic fibrosis patients showed reduced POMC levels compared to controls [ 31 ]. On the other hand, patients with anorexia nervosa have shown significantly higher levels of POMC than controls [ 32 ].…”

Serum Appetite-Regulating Hormone Levels in Cystic Fibrosis Patients: Influence of the Disease Severity and the Type of Bacterial Infection—A Pilot Study

“…Additionally, it appears that the low body mass in CF patients may be associated with disturbances in the levels of hormones that regulate appetite [13,14]. Currently, reports on levels of appetite-regulating hormones in CF are inconclusive and suggest that, in addition to the disease itself, many factors, including types of CFTR mutations, lifestyle, and nutrition, may influence hormone levels [13,14,[32][33][34][35]. Moreover, hormonal disorders of CF are more common in the elderly and are expected to become more frequent as medical care improves and the population ages [36,37].…”