Serum Ischemia-Modified Albumin, Fibrinogen, High Sensitivity C- Reactive Proteins in Type-2 Diabetes Mellitus without Hypertension and Diabetes Mellitus with Hypertension: A Case-Control Study

Sushith, Sushith; Krishnamurthy, Herijenahalli Nagaraju; Reshma, S; Dsa, Janice; Madan, Gopal R; Ashok, Kumar; Prathima, M B; Kalal, Bhuvanesh Sukhlal

doi:10.29252/rbmb.9.2.241

Cited by 10 publications

(4 citation statements)

References 32 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, Sushith S et al reported a higher level of BMI in hypertensive versus non-hypertensive patients with type 2 diabetes. 32 Consistent with our results, Luo et al revealed that Ag-RP neuropeptide might be a potent mediator between appetite and obesity state. 5 Also, similar to the study by Masoodian et al, there was no significant difference in glycemic markers and lipid profile between different BMI tertiles 33 Based on our findings, Ag-RP and α-MSH levels were higher among higher tertiles of BMI; other evidence has also indicated that obese adults have elevated plasma levels of α-MSH and Ag-RP.…”

Section: Discussionsupporting

confidence: 93%

Association between Ag-RP, alpha-MSH and cardiovascular risk factors regarding adherence to diet quality index-international (DQI-I) among obese individuals

Mahmoudinezhad¹,

Farhangi²

2021

J Cardiovasc Thorac Res

View full text Add to dashboard Cite

Introduction: Obesity is a strong promoter of cardiometabolic risk factors and is associated with several chronic comorbidities. Recently, the role of α-melanocyte stimulating hormone (α-MSH) and agouti related peptide (Ag-RP) in regulation of energy balance has attracted much attention. In current study, we evaluated the association between α-MSH and Ag-RP with cardiometabolic factors among obese individuals with different adherence to Diet Quality Index-International (DQI-I) values. Methods: In this research, 188 obese adults aged between 20 and 50 years old and body mass index (BMI) between 30 and 40 kg/m2 were recruited. Dietary intakes of participants and DQI-I calculation was performed using a semi-quantitative food frequency questionnaire (FFQ) with 132 food items. Serum glucose, lipids, insulin, and plasma α-MSH and Ag-RP levels were measured using ELISA kits. Homeostasis model assessment for insulin resistance index (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) were also calculated. Results: Among those with the lowest adherence to DQI-I, Ag-RP was positively associated with systolic blood pressure (SBP) (P = 0.03) among males, which was associated with waist circumference (WC) (P = 0.01) and diastolic blood pressure (DBP) (P = 0.01). Moreover, among males with low and moderate adherence to DQI-I, α-MSH was positively associated with insulin (P = 0.04), weight (P = 0.03), WC (P < 0.01), SDP (P = 0.02) and DBP (P = 0.01). Also, Ag-RP showed a positive association with BMI values (R2 = 0.03; P = 0.03). Conclusion: According to our findings, in obese subjects with poor to moderate adherence to DQI-I, Ag-RP and α-MSH were in positive correlation with cardiometabolic risk factors. These findings further clarify the clinical importance of these parameters as prognostic factors of cardiometabolic abnormalities.

show abstract

Section: Discussionsupporting

confidence: 93%

Association between Ag-RP, alpha-MSH and cardiovascular risk factors regarding adherence to diet quality index-international (DQI-I) among obese individuals

Mahmoudinezhad¹,

Farhangi²

2021

J Cardiovasc Thorac Res

View full text Add to dashboard Cite

show abstract

“…Analyses of clinical and experimental investigations have shown that types one and two DM (DM1 and DM2) are associated with an increase in IMA, the level of which depends on glucose concentration, presence of complications, and comorbidities [125][126][127][128][129]. On the other hand, the formation of IMA in the early stages of DM plays a significant role in the pathogenesis of diabetic complications.…”

Section: Diabetes Mellitus and Itsmentioning

confidence: 99%

Ischemia-Modified Albumin: Origins and Clinical Implications

et al. 2021

View full text Add to dashboard Cite

Albumin is one of the most abundant proteins in the body of mammals: about 40% of its pool is located in the intravascular space and the remainder is found in the interstitial space. The content of this multifunctional protein in blood is about 60-65% of total plasma proteins. A decrease in its synthesis or changes of functional activity can destabilize oncotic blood pressure, cause a violation of transporting hormones, fatty acids, metals, and drugs. Albumin properties change under ischemic attacks associated with oxidative stress, production of reactive oxygen species, and acidosis. Under these conditions, ischemia-modified albumin (IMA) is generated that has a reduced metal-binding capacity, especially for transition metals, such as copper, nickel, and cobalt. The method of determining the cobalt-binding capability of HSA was initially proposed to evaluate IMA level and then licensed as an ACB test for routine clinical analysis for myocardial ischemia. Subsequent studies have shown the viability of the ACB test in diagnosing other diseases associated with the development of oxidative stress. This review examines recent data on IMA generation mechanisms, describes principles, advantages, and limitations of methods for evaluation of IMA levels, and provides detailed analysis of its use in diagnostic and monitoring therapeutic efficacy in different diseases.

show abstract

“…High levels of these proteins are a sign of a recent heart attack. One of the markers of heart attack is the Cardiac Troponin-T. Other biomarkers include fibrinogen and PAI-1, high levels of homocysteine, elevated asymmetric dimethylarginine, and elevated brain natriuretic peptide (also known as B-type) (BNP) [19,20].…”

Section: Introductionmentioning

confidence: 99%

A prospective observational study to assess the cardiac risk factors and treatment patterns in established heart diseases

Reddy

Poojitha

Kavitha

et al. 2022

Cell. Mol. Biomed. Rep.

View full text Add to dashboard Cite

The study aimed to assess established and non-established risk factors and drug therapy problems in the cardiology department and perform a Prospective Observational Study. The study was conducted for a period of 6 months from September 2019 to February 2020 in 200 patients with established heart diseases attending a tertiary care hospital in the cardiology department. A patient interview was conducted using an evaluation form. Among 100 patients with established cardiovascular diseases that were engaged in this study, a high number of patients were males and the majority of the patients were in the age group 'Between' 41-60 years. This study shows smoking and alcohol consumption is the most common risk factors in males, hypertension was the mainly 'established' risk factor for cardiovascular disease followed by Angina and Myocardial infarction. Among non-established risk factors, CKD was the main risk factor in cardiovascular disease followed by cardiovascular accidents. ACE Inhibitors and BB are the drugs mainly used in cardiovascular diseases followed by statins and diuretics. This study throws light on the statistical evidence among the age group and gender risk factors, and drug utilization. In the course of this study use of drug pattern was as follows: Anticoagulants are used in (29%) patients, ACE in (22.5%) patients, Antiplatelets in (68%) patients, diuretic in (34%) patients, Statins in (57%) patients, BB in (67.5%) patients, PPI in (22%) patients, CCB in (19.5%) patients, Nitrates (26.5%) patients, OHA (25%) patients. Similar findings in other studies (Blessy Rachel Thomas) (26) on drug therapy usage were found. There is a need to assess both nonestablished and established risk factors among patients with established heart diseases as in this study, CKD and HTN were the most common peril and counsel patients about their risk factors and social habits and lifestyle changes. There is a need for a clinical pharmacist to counsel about lifestyle changes and assess drug therapy utilization patterns in cardiac patients.

show abstract

Serum Ischemia-Modified Albumin, Fibrinogen, High Sensitivity C- Reactive Proteins in Type-2 Diabetes Mellitus without Hypertension and Diabetes Mellitus with Hypertension: A Case-Control Study

Cited by 10 publications

References 32 publications

Association between Ag-RP, alpha-MSH and cardiovascular risk factors regarding adherence to diet quality index-international (DQI-I) among obese individuals

Association between Ag-RP, alpha-MSH and cardiovascular risk factors regarding adherence to diet quality index-international (DQI-I) among obese individuals

Ischemia-Modified Albumin: Origins and Clinical Implications

A prospective observational study to assess the cardiac risk factors and treatment patterns in established heart diseases

Contact Info

Product

Resources

About