Serum iron concentration is a useful biomarker for assessing the level of inflammation that causes systemic symptoms in bovine acute mastitis similar to plasma haptoglobin

Abstract

The aim of present study was to evaluate the precision of plasma haptoglobin (HPT), serum iron (Fe) and plasma transferrin (Tf) concentrations as biomarkers of the severity of acute mastitis (AM) in cows. Fourteen Holstein Friesian cows with AM were divided into severe (n=8) and mild groups (n=6) based on systemic and local inflammation, and 12 healthy cows were also enrolled as controls. As a result, significant changes were observed in plasma HPT and serum Fe concentrations. The proposed cut-off points for plasma HPT and serum Fe concentrations for the severity of AM in cows based on receiver operating characteristic analyses were >10.3 µ g/m l and <49.0 µ g/d l , respectively. No significant difference was observed in the plasma Tf concentration.

Evaluation of the plasma oxylipin and endocannabinoid profile and the platelet and plasma proteome in postpartum dairy cows experiencing elevated systemic inflammation

“…TFRC1 is a well-known transmembrane protein found in nearly all cells and is responsible for binding ironbound transferrin and mediating cellular iron uptake [56][57][58] . Numerous studies have demonstrated the relationship between serum iron concentrations and inflammation in dairy cows [59][60][61][62] . In the referenced studies, cows suffering from inflammation, as indicated by elevated Hp Grantz et al concentrations, had significantly decreased serum iron concentrations compared to control cows.…”

Usefulness of Measuring Serum Amyloid A Concentration in Japanese Black Cattle in Clinical Practice

“…The results of the second trial showed a positive correlation between the SAA and the α-globulin, sialic acid, and fibrinogen concentrations and a negative correlation with the serum iron concentration. α-globulin, sialic acid, and fibrinogen are positive indicators of inflammation, whereas serum iron is considered a negative indicator of inflammation in cattle [ 28 , 29 ]. The findings of this study clarified that the concentration of SAA increased due to inflammation in Japanese Black cattle.…”

Varijabilnost biokemijskih i hematoloških parametara ovisno o pojavnosti mastitisa kod muznih krava

“…Puppel and Kuczyńska (2016) stated that the changes in the blood-related AST activity can be a consequence of their increased cellular activity, as well as a result of cellular structural damage. The liver function effects on the inflammatory markers of serum's biochemical values in the cows with an acute mastitis were also studied by Tsukano and Suzuki (2020). They determined that there were no significant differences in the serum AST or GGT related to the liver function.…”

“…The aforementioned authors also determined that a susceptibility to significant infectious diseases during the periparturient period, such as mastitis and metritis, increases, as is, resultantly, the rate of culling. Furthermore, the Fe serum concentrations represent a useful biomarker of an acute mastitis severity in cows and has a further advantage because it can be easily measured at a low cost (Tsukano and Suzuki, 2020).…”