Serum irisin levels in newly diagnosed type-II diabetic patients: No association with the overall diet quality but strong association with fruit intake

Kopuz, Tuba N Yildiz; Dağdeviren, Murat; Fisunoğlu, Mehmet

doi:10.1016/j.clnesp.2022.03.022

Cited by 3 publications

(3 citation statements)

References 55 publications

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“…It has been proved that irisin might regulate glucose metabolism, promote glucose utilization, and improve blood glucose disorders (41). Compared with healthy people, T2DM patients had lower circulating irisin levels, while the circulating irisin levels of long-standing T1DM patients and newly diagnosed T2DM patients were higher than that of the control group (42)(43)(44)(45)(46)(47). Even, in patients with diabetic complications including diabetic retinopathy and diabetic nephropathy, irisin levels may be further reduced (48,49).…”

Section: Irisin and Diabetesmentioning

confidence: 99%

The emerging roles of irisin in vascular calcification

Wang,

Hu,

Pan

2024

Front. Endocrinol.

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Vascular calcification is a common accompanying pathological change in many chronic diseases, which is caused by calcium deposition in the blood vessel wall and leads to abnormal blood vessel function. With the progress of medical technology, the diagnosis rate of vascular calcification has explosively increased. However, due to its mechanism’s complexity, no effective drug can relieve or even reverse vascular calcification. Irisin is a myogenic cytokine regulating adipose tissue browning, energy metabolism, glucose metabolism, and other physiological processes. Previous studies have shown that irisin could serve as a predictor for vascular calcification, and protect against hypertension, diabetes, chronic kidney disease, and other risk factors for vascular calcification. In terms of mechanism, it improves vascular endothelial dysfunction and phenotypic transformation of vascular smooth muscle cells. All the above evidence suggests that irisin plays a predictive and protective role in vascular calcification. In this review, we summarize the association of irisin to the related risk factors for vascular calcification and mainly explore the role of irisin in vascular calcification.

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Section: Irisin and Diabetesmentioning

confidence: 99%

The emerging roles of irisin in vascular calcification

Wang,

Hu,

Pan

2024

Front. Endocrinol.

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“…Several studies have suggested that irisin may also have an impact on lipid profile, which refers to the levels of different types of fats in the blood [27,28]. The irisin hormone has been a topic of interest in recent research due to its potential impact on lipid profile [29,30]. Several studies have suggested that the irisin hormone may play a role in regulating lipid metabolism and potentially influencing the lipid profile of individuals.…”

Section: Impact Of Irisin-vitamin D Relationship On Lipid Profilementioning

confidence: 99%

Impact of Vitamin D Status on Irisin Hormone Level in Type 2 Diabetic Iraqi Women

Al-Sallami,

Smesim,

Al-Janabi

et al. 2024

BIO Web Conf.

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Irisin, a hormone discovered in 2012, has gained attention for its potential role in regulating metabolism and promoting fat burning. This study was conducted on 180 women from Najaf Governorate/Iraq with T2DM who were divided into two main groups: the first group 90 T2DM with vitamin D deficiency and the second group 90 T2DM without vitamin D deficiency. Serum 25(OH)D and irisin levels were analyzed for the purpose of knowing the effect of vitamin D status on circulating irisin in relation to lipid profile and glycemic control in women with type 2 diabetes.The finding of the current study has been signified the effect of vitamin D deficiency may on serum irisin level in T2DM women. The vitamin D-deficient T2DM women had lower irisin levels than normal vitamin D T2DM women consistent with our hypothesis.

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“…Irisin may play a role in the pathophysiology of obesity and the metabolic problems that accompany it [9]. According to the vast majority of research, there is an association between irisin levels and adiposity, as well as other biochemical indicators of obesity in humans, even though others have discovered the contrary [10,11]. As a result, the goal of this study was to compare patients with T2DM to healthy controls in terms of Irisin levels and their relation with BMI, as well as metabolic and anthropometric data.…”

Section: Introductionmentioning

confidence: 99%

Determination of Irisin, Body Mass Index, and Other Biochemical Parameters in a Sample of Iraqi Type II Diabetic Patients

Chachan,

Huda Farhan,

Shatha Hamed

2022

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Evidence suggests that Irisin, a peptide hormone, may play a role in lipid metabolism, insulin resistance, and obesity. On the other hand, its role in type 2 diabetic Mellitus [T2DM] in humans is uncertain. As a result, we investigated if irisin levels in T2DM patients were dysregulated and whether there was a link between serum irisin levels and anthropometric obesity indices and biochemical parameters. [T2DM patients] group [n = 90] and control groups [n = 90], males [n=81], females [n=99] were selected among 180 people. [43.17 ±11.13] years was the average age. ELISA was used to measure serum irisin levels. The mean serum Irisin level in the control group was considerably higher [P<0.01] than in the case group [6.9±1.3 vs. 5.8±1.2], respectively. The results showed that body mass index and irisin [P-value<0.001]. Irisin seems to have a significant negative connection [P-value<0.001] with body mass index, fasting blood sugar, glycated hemoglobin, insulin, and homeostasis model assessment of insulin resistance. There was also a substantial negative association between irisin, low-density lipoprotein, and triglyceride, but none with cholesterol or high-density lipoprotein. In conclusion, irisin appears to be involved in regulating glucose metabolism. In this investigation, circulating irisin concentrations were considerably lower in T2DM patients. These findings imply that higher plasma irisin levels in T2DM are linked to adiposity indices. As a result, irisin has the potential to be a novel therapeutic option in the field of obesity.

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Serum irisin levels in newly diagnosed type-II diabetic patients: No association with the overall diet quality but strong association with fruit intake

Cited by 3 publications

References 55 publications

The emerging roles of irisin in vascular calcification

The emerging roles of irisin in vascular calcification

Impact of Vitamin D Status on Irisin Hormone Level in Type 2 Diabetic Iraqi Women

Determination of Irisin, Body Mass Index, and Other Biochemical Parameters in a Sample of Iraqi Type II Diabetic Patients

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