Serum interleukin-8 levels are elevated in patients with ovarian endometrioma

Ohata, Yorie; Harada, Tasuku; Miyakoda, Hiroko; Taniguchi, Fuminori; Iwabe, Tomio; Terakawa, Naoki

doi:10.1016/j.fertnstert.2007.07.1355

Cited by 40 publications

(28 citation statements)

References 20 publications

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“…Women with and without endometriosis have been previously reported to have comparable serum interleukin-6 (IL-6) [25,26], IL-8 [25], TNF-α, and IL-1 [7, 25-27] levels. However, some studies reported higher peripheral levels of IL-6 [27], IL-8 [28], TNF-α [29], and interferon-γ [27] in patients with endometriosis than in controls.…”

Section: Discussionmentioning

confidence: 99%

The Role of Serum Caspase 3 Levels in Prediction of Endometriosis Severity

Kaya

Alay

Güraslan

et al. 2018

Gynecol Obstet Invest

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Background/Aims: To identify the role of serum caspase 3, Annexin A2 (ANXA2), and Soluble Fas Ligand (sFasL) levels in the prediction of endometriosis severity. Methods: The study was performed on 90 women who were candidates for laparoscopic surgery due to endometrioma or any other benign ovarian cysts detected by ultrasound examination, pelvic pain, or infertility. The control group comprised 29 patients. The second group comprised 29 patients with stage I–II endometriosis and the third group comprised 30 patients with stage III–IV endometriosis. Results: Significant differences were detected between the control and stage III–IV endometriosis groups and between stage I–II and stage III–IV endometriosis groups in terms of caspase-3 levels (both, p < 0.001), ANXA2 levels (p = 0.007 and p = 0.002), and sFasL levels (p = 0.022 and p = 0.044). After receiver operating characteristic analysis, the area under curve was 93% (95% CI 57–82) at 10.7 ng/mL cut-off level for caspase-3 with 90% sensitivity and 87% specificity. Conclusion: Serum caspase-3 level may be a reliable predictor of endometriosis severity.

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Section: Discussionmentioning

confidence: 99%

The Role of Serum Caspase 3 Levels in Prediction of Endometriosis Severity

Kaya

Alay

Güraslan

et al. 2018

Gynecol Obstet Invest

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“…By using a serum IL-8 cut-off point of 24, we were able to detect endometriosis cases with 62.0% sensitivity and 73.0% specificity. The results from other studies have been conflicting (25,26).…”

Section: Discussionmentioning

confidence: 99%

Serum interleukin-8, CA-125 levels, neutrophil to lymphocyte ratios and combined markers in the diagnosis of endometriosis

Sayan¹

2013

Turk J Med Sci

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“…We recently reported that serum IL-8 concentration in patients with ovarian endometrioma was higher than in patients without endometrioma. Measuring the serum IL-8 concentration provided a highly sensitive marker to diagnose endometriosis [13]. In addition, Wu et al [14] showed that ectopic endometriotic lesions produce more IL-8 protein than their corresponding eutopic endometrium, suggesting that ectopic endometriotic cells innately possess characteristics different from eutopic endometrial cells.…”

Section: Discussionmentioning

confidence: 99%

Gonadotropin-Releasing Hormone Analogues Reduce the Proliferation of Endometrial Stromal Cells but Not Endometriotic Cells

Taniguchi¹,

Higaki²,

Azuma³

et al. 2012

Gynecol Obstet Invest

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Aims: We investigated the potential of gonadotropin-releasing hormone (GnRH) agonists and GnRH antagonists to inhibit cell proliferation in endometriotic and endometrial stromal cells. Methods: Twenty patients with ovarian endometriomas and 18 patients with uterine fibromas were recruited. Endometriotic and endometrial stromal cells were obtained from the ovarian chocolate cyst linings and the eutopic endometria of premenopausal women with uterine fibromas, respectively. Results: GnRH agonist or antagonist treatment attenuated tumor necrosis factor (TNF)-α-induced cell proliferation in the endometrial stromal cells, whereas endometriotic stromal cells did not respond to treatment. The endometriotic stromal cells exhibited a decreased expression of the type I GnRH receptor compared with the endometrial stromal cells. GnRH agonists or antagonists did not repress TNF-α-induced IL-8 production in endometriotic stromal cells. Conclusion: GnRH agonists and antagonists have similar effects in slowing the growth of endometrial stromal cells. Endometriotic stromal cells resist the antiproliferative effect of GnRH agonists and antagonists.

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Serum interleukin-8 levels are elevated in patients with ovarian endometrioma

Cited by 40 publications

References 20 publications

The Role of Serum Caspase 3 Levels in Prediction of Endometriosis Severity

The Role of Serum Caspase 3 Levels in Prediction of Endometriosis Severity

Serum interleukin-8, CA-125 levels, neutrophil to lymphocyte ratios and combined markers in the diagnosis of endometriosis

Gonadotropin-Releasing Hormone Analogues Reduce the Proliferation of Endometrial Stromal Cells but Not Endometriotic Cells

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