Serum interleukin-8, CA-125 levels, neutrophil to lymphocyte ratios and combined markers in the diagnosis of endometriosis

Abstract

Flash vacuum pyrolysis (FVP) or thermolysis (FVT), an environmentally friendly method for studying organic reaction mechanisms as well as synthesis, was applied to a series of oxalate dimers (1, 3, 5, 7, 9, 11, 13, and 15) to synthesise monomeric enes, dienes, and a triene (2, 4, 6, 8, 10, 12, 14, and 16). All steroidal monomers were identified by spectroscopic means.

Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis

“…Twenty‐two studies included 3626 participants (Figure ) . Nineteen prospective observational studies and three retrospective observational studies were included for analysis. Two studies did not include analysable data and the authors could not be contacted .…”

“…Fifteen studies recruited patients from infertility clinics and eight studies included recruited patients from general gynaecology clinic or elective gynaecological theatre sessions . Twelve studies reported including patients with pain symptoms . Twelve studies recruited patients with pre‐operative imaging available indicating an ovarian cyst .…”

“…Twelve studies reported including patients with pain symptoms . Twelve studies recruited patients with pre‐operative imaging available indicating an ovarian cyst . Endometriosis was confirmed by histology collected at either laparoscopic, laparoscopy or laparotomic, or did not specify the route of surgery .…”

“…Twelve studies recruited patients with pre‐operative imaging available indicating an ovarian cyst . Endometriosis was confirmed by histology collected at either laparoscopic, laparoscopy or laparotomic, or did not specify the route of surgery . The staging of endometriosis was classified using the revised American Fertility Society classification 1985 or the revised American Fertility Society classification 1997 .…”

“…CA 125 is raised in endometriosis through stimulation of coelomic epithelia and is the most investigated non‐invasive diagnosis marker. Individual studies have methodological limitations in patient selection, poor conduct of the index test, and poor conduct of the reference test . Two diagnostic reviews exist; however, the first is over 15 years old and includes studies with high risk of verification bias and the second is of poor methodological quality …”