Serum interleukin‐6 level is a useful marker in evaluating therapeutic effects of levamisole and Chinese medicinal herbs on patients with oral lichen planus

Sun, Aihua; Chia, Jean-San; Chang, Julia Yu Fong; Chiang, Chun-Pin

doi:10.1034/j.1600-0714.2002.310402.x

Cited by 59 publications

(87 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In previous studies of patients with oral lichen planus, serum and salivary IL-6 levels were decreased significantly at a mean 42 days and 0.5-3 months (15-90 days) after treatment. 12,31 We cannot compare these results with ours due to different patient characteristics. However, we cannot deny the possibility that the salivary concentrations of IL-6 might have come down to the levels of controls, if we had collected saliva from the OSCC patients at the time of 2-3 months after treatment.…”

Section: Discussionmentioning

confidence: 77%

“…IL-6 is produced by various cells types, including lymphoid cells, monocytes, fibroblasts, endothelial cells, oral epithelial cells, and several types of tumor cells. 8, 10, 11 Sun et al 12 suggested that IL-6 was produced by SCC, and contributed to the progression of the disease. We could not measure the serum levels of IL-6 in the patients and controls in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…St. John et al 2 reported the mean concentrations of IL-6 in the serum were 86.5 pg/mL and 0 pg/mL, in patients with OSCC and healthy controls, respectively. Sun et al 12 reported that the mean serum levels of IL-6 were 3.4±3.1 pg/mL and 2.0±1.5 pg/mL in patients with erosive oral lichen planus and healthy subjects, respectively. From the results of the previous and present studies, it is natural that IL-6 in saliva was produced by not only cancer cells but also peripheral circulation.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 Interleukin-6 (IL-6) is a multifunctional cytokine that participates in the inflammatory and immune responses. [10][11][12] Proinflammatory cytokines, such as IL-6, have been shown to directly promote the growth of certain types of cancer, and is associated with increased the rate of metastasis. 2,13 However, IL-6 has dual effects, inhibiting the growth of some cells while stimulating the growth of others.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma

Sato¹,

Goto²,

Murata³

et al. 2010

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

View full text Add to dashboard Cite

Objective: To elucidate the changes in interleukin-6 (IL-6) levels in whole saliva during the treatment phase in patients with oral squamous cell carcinoma (OSCC).Study Design: Twenty-nine consecutive inpatients with OSCC were enrolled in this study. Stimulated saliva was collected three times (just after hospitalization)[period 1], just before main treatment (surgery: 26/29 cases)[period 2] and at the time of discharge [period 3]. The mean intervals were 11±8 days between periods 1 and 2 and 30±18 days between periods 2 and 3. As controls, 19 age-matched healthy volunteers were also recruited. IL-6 concentrations were measured by a highly sensitive chemiluminescent enzyme immunoassay.

show abstract

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma

Sato¹,

Goto²,

Murata³

et al. 2010

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

View full text Add to dashboard Cite

show abstract

“…В механизме развития ПЛ СОР большое значение играют иммунные нарушения [19,33,44,63,81,88,121,128,150,159,163].…”

unclassified

Clinical and laboratory rationale for photodynamic therapy in patients with severe complicated oral lichen planus

2015

Stomat.

View full text Add to dashboard Cite

Low-Dose Excimer 308-nm Laser for the Treatment of Oral Lichen Planus

Trehan¹,

Taylor²

2004

Arch Dermatol

View full text Add to dashboard Cite

Background: Lichen planus is a difficult-to-treat chronic inflammatory disorder that affects mucous membranes, causing inanition, halitosis, and dyspareunia.Objective: To evaluate the novel use of low-dose 308-nm excimer laser radiation for the treatment of symptomatic oral lichen planus (OLP).Design: A single-center, before-after trial.Setting: Academic clinical research center.Patients: Nine patients with symptomatic, biopsyproven OLP, unresponsive to conventional therapies, were recruited from the dermatology clinics of the Massachusetts General Hospital in Boston. Eight participants completed the entire study, and 1, despite early improvement, did not complete the study because of hospitalization for an unrelated reason.Intervention: With a narrow, fiberoptic handpiece to target precisely only diseased sites, 308-nm excimer laser radiation was delivered at an initial dose of 100 mJ/cm 2 once a week.Main Outcome Measure: A visual analog scale was used to grade subjective disease severity. Clinical improvement was graded in quartiles as follows: poor (Ͻ25%), fair (25%-50%), good (51%-75%), and excellent (Ͼ75%). Follow-up visits occurred for up to 18 months. A paired t test was performed to evaluate efficacy of treatment.Results: Treatments were painless and well tolerated. Five patients demonstrated overall excellent clinical and subjective improvement after 7 treatments. Two participants with nonerosive OLP were deemed fair responders. The only poor responder in the study also had chronic active hepatitis C infection. Overall improvement was statistically significant (PϽ.05), and for the responders, remission times ranged from 2 to 17 months. Conclusion:Low-dose treatment with the excimer 308-nm laser can be very effective in treating symptomatic and especially erosive OLP, an otherwise notoriously difficult-to-control disease.

show abstract

Serum interleukin‐6 level is a useful marker in evaluating therapeutic effects of levamisole and Chinese medicinal herbs on patients with oral lichen planus

Abstract: We conclude that levamisole and levamisole plus Chinese medicinal herbs can modulate the serum IL-6 level in OLP patients. IL-6 may be a useful marker in evaluating therapeutic effects and in monitoring the disease status of OLP.

Cited by 59 publications

References 25 publications

Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma

Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma

Clinical and laboratory rationale for photodynamic therapy in patients with severe complicated oral lichen planus

Low-Dose Excimer 308-nm Laser for the Treatment of Oral Lichen Planus

Contact Info

Product

Resources

About