Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma

Sato, Jun; Goto, Jun; Murata, T.; Kitamori, Shogo; Yamazaki, Yutaka; Satoh, Akira; Kitagawa, Yoshimasa

doi:10.1016/j.tripleo.2010.03.040

Cited by 46 publications

(60 citation statements)

References 30 publications

(43 reference statements)

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“…Synthesis of CRP is regulated by proinflammatory cytokines such as IL-1 and IL-6, 2 and increased serum concentrations of IL-6 have been shown to correlate with increased serum concentration of CRP in patients with head and neck cancer. 2,28 Inflammatory mechanisms are activated by cancer-induced tissue damage and by factors locally released by certain tumors. 23 Recruited inflammatory cells releases cytokines that induce cancer-related pain.…”

Section: Discussionmentioning

confidence: 99%

Pain may predict poor prognosis in patients with oral squamous cell carcinoma

Sato

Yamazaki

Satoh

et al. 2011

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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Objectives:We have previously reported that the histological mode of invasion of oral squamous cell carcinoma (OSCC) is a significant risk factor for pain. We sought to determine whether pain is a risk factor for poor prognosis in patients with OSCC. Study Design:We evaluated the relationships between overall survival rates (OSRs) and clinicopathological variables, including gender, age, Tand N-stages, pathological findings and pain in 109 consecutive patients with untreated OSCC. Results:Of these 109 patients, 40 (37%) reported spontaneous pain.Univariate analysis showed that the OSR of patients with spontaneous pain was significantly lower than that of patients without pain (p=0.002).Multivariate analysis revealed that spontaneous pain and N-stage were significant independent predictors of OSR. Conclusion:This is the first report showing that spontaneous pain before treatment may be associated with poor prognosis in patients with OSCC.3

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Section: Discussionmentioning

confidence: 99%

Pain may predict poor prognosis in patients with oral squamous cell carcinoma

Sato

Yamazaki

Satoh

et al. 2011

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

Self Cite

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“…Cytokines and chemokines have been analysed in patients with OSCC [19][20][21][22][23][24][25][26][27][28][29], and in potentially malignant disorders, most commonly interleukin-6 (IL-6) [19,21,22,[30][31][32][33]. IL-6 is a multifunctional cytokine produced by macrophages, neutrophils, fibroblasts, keratinocytes and endothelial cells [34].…”

Section: Introductionmentioning

confidence: 99%

Salivary and serum interleukin-6 levels in proliferative verrucous leukoplakia

et al. 2015

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“…and IL-8 have been studied in head and neck cancer but with conflicting results, inadequate follow-up and on different types of tumours (7)(8)(9)(10).…”

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confidence: 99%

Possible role for interleukins as biomarkers for mortality and recurrence in oral cancer

et al. 2015

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Abstract:Objectives: Salivary and serum levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) have previously been studied in oral cancer with conflicting results. Methods: We designed a controlled study to assess the correlation between pretreatment salivary and serum levels of IL-6 and IL-8, and all-cause survival and cancer recurrence in oral cancer patients. Results: Fifty-two oral cancer patients and 52 healthy control cases were selected. In univariate analysis, salivary IL-6 and IL-8 seemed to be more expressed in cases (p<.001 and p=.010 respectively). Multivariate analysis showed that higher pretreatment saliva IL-6 levels were significantly associated with better survival (HR, 8.62; 95% CI, p=.031). Conclusions: To date, this is the largest prospective controlled study that analyses the pre-treatment salivary and serum levels of IL-6 and IL-8 in oral cancer patients, suggesting salivary IL-6 as possible prognostic biomarkers, but further validation on a larger sample is still necessary. Thank you for your decision and comments regarding the above manuscript.In order to expedite the processing of the revised manuscript, we have attempted to answer the reviewers' comment in a point-by-point manner.The attached highlights the changes in yellow.#Reviewer 1:-As required primary and secondary endpoints have been better described at the beginning of the M&M section.-Some lines about the sample size have been added, as required, when discussing about statistical methods.-As suggested, in the Discussion section the weaknesses and strengths of the study have been discussed; moreover, the potential clinical applications of the achieved results have been better commented.We now hope that our revisions will be acceptable. Conclusions: To date, this is the largest prospective controlled study that analyses the pre-treatment salivary and serum levels of IL-6 and IL-8 in oral cancer patients, suggesting salivary IL-6 as possible prognostic biomarkers, but further validation on a larger sample is still necessary.

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Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma

Cited by 46 publications

References 30 publications

Pain may predict poor prognosis in patients with oral squamous cell carcinoma

Pain may predict poor prognosis in patients with oral squamous cell carcinoma

Salivary and serum interleukin-6 levels in proliferative verrucous leukoplakia

Possible role for interleukins as biomarkers for mortality and recurrence in oral cancer

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