Serum Interleukin-6 and Adiponectin Levels in Patients with Active or Inactive Behçet’s Disease

Abstract

A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Beh çet's di se a se (BD) is a chro nic syste mic inf lam ma tory di se a se and its etio pat ho ge ne sis still re ma ins unk nown. Cyto ki nes play a ro le in im mu ne res pon se and inf lam ma tory re ac ti ons. The aim of this study is to de ter mi ne the le vels of pro inf lam ma tory cyto ki ne in ter le ukin-6 (IL-6) and an ti-inf lam ma tory cyto ki ne adi po nec tin in the sera of pa ti ents with BD and to assess their im por tan ce as bi o lo gi cal mar kers for di se a se ac ti vity. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : Forty-four BD pa ti ents [19 ma les, 25 fe ma les, age: 35.65 ± 10.84 yrs (me an ± stan dart de vi a ti on) (SD)] and 25 he althy con trols (10 ma les, 15 fe ma les, age: 29.80 ± 8.20 yrs) we re inc lu ded in the study. Pa ti ents we re divided into ac ti ve or inac ti ve gro ups ac cor ding to the ir cli ni cal and la bo ra tory fin dings (acti ve, n= 21; inac ti ve, n= 23). We de ter mi ned se rum IL-6 le vels using the che mi lu mi nes cen ce method, and se rum adi po nec tin le vels by ELI SA met hod. Re sults we re ex pres sed as me an ± stan dard er ror (SE). R Re e s su ul lt ts s: : Se rum le vels of IL-6 and adi po nec tin in BD pa ti ents (n= 44) (5.24 ± 0.84 pg/mL; 22.31 ± 1.71 µg/mL, res pec ti vely) we re si mi lar to the con trol gro up (n= 25) (4.59 ± 1.01 pg/mL; 21.68 ± 1.91 µg/mL, res pec ti vely). No sig ni fi cant dif fe ren ce was fo und in IL-6 and adi po nec tin le vels bet we en the ac ti ve (n= 21), inac ti ve (n= 23) and con trol (n= 25) gro ups. C Co on nc c l lu u s si i o on n: : In pa ral lel with the pre sen ce of inf lam ma ti on and in cre a sed CRP, eryt hrocy te se di men ta ti on ra te and white blood cell co unt, hig her IL-6 and lo wer adi po nec tin le vels were ex pec ted in ac ti ve BD pa ti ents com pa red to the con trols. However, they were found to be si mi lar in all gro ups. We conc lu de that on go ing an ti-inf lam ma tory tre at ment sho uld be ta ken in to con si de ra ti on whi le in ter pre ting the cyto ki ne levels in the se pa ti ents. K Ke ey y W Wo or rd ds s: : Beh cet's syndro me; adi po ki nes; in ter le u kin-6 Ö ÖZ ZE ET T A Am ma aç ç: : Beh çet has ta lı ğı (BH), kro nik sis te mik inf la ma tu ar bir has ta lık olup eti yo pa to ge ne zi he nüz bi lin me mek te dir. İmmun ce vap ve inf la ma tu var sü reç iliş ki sin de si to kin ler rol oy na mak tadır lar. Bu ça lış ma nın ama cı, BH'lı has ta la rın se rum la rın da pro-inf la ma tu ar bir si to kin olan IL-6 ile an ti-inf la ma tu ar si to kin olan adi po nek ti nin se vi ye le ri ni öl çe rek, bun la rın has ta lı ğın ak ti vi te sin de bi yo lo jik be lir teç ola rak et ki le ri ni be lir le mek tir. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Ça lış ma ya 44 BH'lı has ta (19 er kek, 25 ka dın, yaş or ta la ma sı 35.65 ± 10 yıl) ve kon trol gru bu ola rak da 25 sağ lık lı ki şi (10 er kek, 15 ka dın, yaş or ta la ma sı 29.80 ± 8.20 yıl) alın mış tır. Has ta lar kli ni...