Serum interleukin-37 (IL-37) and its gene polymorphism in Iranian Behcet's disease patients: Association with disease manifestations and activity

Gholijani, Nasser; Daryabor, Gholamreza; Yazdani, Mehrdad; Vazani, Negin; Shabbooei, Bahareh; Zahed, Maryam; Ranjbar, Mohammad Ali; Sadeghi, Meysam; Amirghofran, Zahra

doi:10.1016/j.mgene.2020.100794

Cited by 4 publications

(5 citation statements)

References 34 publications

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“…Overall, based on previous studies it seems that the AA genotype frequency is relatively low [28,35] that might be responsible for these contrasting results. Interestingly, in our previous study in Behcet's disease also we were not able to detect AA genotype in Iranian population [36]. These observation might simply indicate the differences in ethnicity, clinical heterogeneity or sample size and probably further studies with larger sample size could address this issue.…”

Section: Discussionmentioning

confidence: 54%

“…Zhang et al found no correlation between IL-37 SNPs (rs2723186, rs3811046, rs4241122, rs4364030, rs4392270) and susceptibility to RA [37]. GholiJani et al also did not find any association between IL-37 rs4241122 and Behcet's disease [36]. These discrepancies between studies mainly reflect the nature of the disease and also might point out a pathogenetic role of IL37 rs4241122 in GD.…”

Section: Discussionmentioning

confidence: 98%

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Association between IL 37 gene variants (rs4241122 and rs2723186) and Graves disease risk

Gholijani¹,

Daryabor²,

Malekmakan³

et al. 2022

J Clin Images Med Case Rep

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Introduction: Graves Disease (GD) is the most common cause of primary hyperthyroidism. It is an autoimmune disorder characterized by the presence of thyrotropin related antibodies that stimulate thyroidal cells, resulting in an overproduction of thyroid hormones. It has been reported that cytokines might be involved in the GD pathogenesis. So, aim of the present study was to investigate the possible associations between IL-37 Single Nucleotide Polymorphisms (SNPs) and susceptibility to GD.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 98%

Association between IL 37 gene variants (rs4241122 and rs2723186) and Graves disease risk

Gholijani¹,

Daryabor²,

Malekmakan³

et al. 2022

J Clin Images Med Case Rep

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“…BD is a mixed-pattern disease characterized by both autoinflammatory and autoimmune features that develop in genetically susceptible individuals exposed to environmental factors [7]. The genetic background is strong in BD pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Behçet’s Disease: A Comprehensive Review on the Role of HLA-B*51, Antigen Presentation, and Inflammatory Cascade

Khoshbakht,

Başkurt,

Vural

et al. 2023

IJMS

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Behçet’s disease (BD) is a complex, recurring inflammatory disorder with autoinflammatory and autoimmune components. This comprehensive review aims to explore BD’s pathogenesis, focusing on established genetic factors. Studies reveal that HLA-B*51 is the primary genetic risk factor, but non-HLA genes (ERAP1, IL-10, IL23R/IL-12RB2), as well as innate immunity genes (FUT2, MICA, TLRs), also contribute. Genome-wide studies emphasize the significance of ERAP1 and HLA-I epistasis. These variants influence antigen presentation, enzymatic activity, and HLA-I peptidomes, potentially leading to distinct autoimmune responses. We conducted a systematic review of the literature to identify studies exploring the association between HLA-B*51 and BD and further highlighted the roles of innate and adaptive immunity in BD. Dysregulations in Th1/Th2 and Th17/Th1 ratios, heightened clonal cytotoxic (CD8+) T cells, and reduced T regulatory cells characterize BD’s complex immune responses. Various immune cell types (neutrophils, γδ T cells, natural killer cells) further contribute by releasing cytokines (IL-17, IL-8, GM-CSF) that enhance neutrophil activation and mediate interactions between innate and adaptive immunity. In summary, this review advances our understanding of BD pathogenesis while acknowledging the research limitations. Further exploration of genetic interactions, immune dysregulation, and immune cell roles is crucial. Future studies may unveil novel diagnostic and therapeutic strategies, offering improved management for this complex disease.

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“…1 BD is considered a mixed pattern disease with autoinflammatory and autoimmune features that develop in genetically susceptible people under the influence of environmental factors. [2][3][4][5] The most substantial genetic risk factor is the presence of HLA-B51; the contribution of HLA-B51 among all genetic factors is calculated as 20%. 6 In recent years, variations in non-HLA genes such as endoplasmic reticulum aminopeptidase enzyme 1 (ERAP1), IL-10 and IL23R/IL-12RB2 have also been proposed as genetic susceptibility loci.…”

Section: Introductionmentioning

confidence: 99%

“…The disease is named after Dr. Hulusi Behçet, a Turkish dermatologist who first described this disease in 1937 as a syndrome with three findings: recurrent oral ulcers, genital ulcers (GUs), and uveitis 1 . BD is considered a mixed pattern disease with autoinflammatory and autoimmune features that develop in genetically susceptible people under the influence of environmental factors 2–5 . The most substantial genetic risk factor is the presence of HLA‐B51 ; the contribution of HLA‐B51 among all genetic factors is calculated as 20% 6 .…”

Section: Introductionmentioning

confidence: 99%

The skin in Behçet's disease: Mucocutaneous findings and differential diagnosis

Vural

Boyvat

2022

JEADV Clinical Practice

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Behçet's disease (BD) is a chronic multisystemic inflammatory disease with vasculitis and skin findings. Attacks and remissions characterize the course of the disease. In general, the disease activity decreases with advanced age. Skin symptoms are characteristic of BD and they are the most common findings in the course of the disease. The earliest sign of the disease is almost always recurrent oral aphthous ulcers. Genital ulcers are very specific for BD and they are the equivalent of oral ulcers in the genital area. The most common location is labium majus in females and scrotum in males. The papulopustular lesions are mainly observed on the lower extremities in BD patients. Erythema nodosum-like lesions and superficial thrombophlebitis are relatively common skin findings. Extragenital ulcerations presenting on the intertriginous area are rare but specific for the disease. The clinical skin manifestations are crucial for the diagnosis of BD, as there is no pathognomonic confirmatory laboratory test.

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Serum interleukin-37 (IL-37) and its gene polymorphism in Iranian Behcet's disease patients: Association with disease manifestations and activity

Cited by 4 publications

References 34 publications

Association between IL 37 gene variants (rs4241122 and rs2723186) and Graves disease risk

Association between IL 37 gene variants (rs4241122 and rs2723186) and Graves disease risk

Behçet’s Disease: A Comprehensive Review on the Role of HLA-B*51, Antigen Presentation, and Inflammatory Cascade

The skin in Behçet's disease: Mucocutaneous findings and differential diagnosis

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