Association between IL 37 gene variants (rs4241122 and rs2723186) and Graves disease risk

Abstract

Introduction: Graves Disease (GD) is the most common cause of primary hyperthyroidism. It is an autoimmune disorder characterized by the presence of thyrotropin related antibodies that stimulate thyroidal cells, resulting in an overproduction of thyroid hormones. It has been reported that cytokines might be involved in the GD pathogenesis. So, aim of the present study was to investigate the possible associations between IL-37 Single Nucleotide Polymorphisms (SNPs) and susceptibility to GD.