Serum Intercellular Adhesion Molecule-1 and Long-Term Response to IFN-α2b Therapy in Chronic Hepatitis C

Bagnasco, Marcello; Riccio, Anna Maria; Sinelli, Nicoletta; Campo, N.; Battifora, M.; Canonica, Giorgio Walter; Picciotto, Antonino

doi:10.1089/jir.1998.18.963

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…1). Furthermore, in contrast with the observations of Baguasco et al, 11 who noted higher basal pretreatment ICAM-1 levels in responders to therapy, compared with non-responders, in our patients pretreatment levels in responders and non-responders did not differ significantly.…”

Section: Discussioncontrasting

confidence: 99%

Cell adhesion molecules and hyaluronic acid as markers of inflammation, fibrosis and response to antiviral therapy in chronic hepatitis C patients

Granot

Ashur

2001

Mediators of Inflammation

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OBJECTIVE: Cell adhesion molecules (intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1)) and hyaluronic acid, markers of inflammation and fibrosis were monitored in hepatitis C patients to determine whether changes in plasma levels, during antiviral treatment, can predict long-term response to therapy. METHODS: In 55 patients with chronic hepatitis C virus (HCV), 33 treated with interferon (IFN) and 22 treated with IFN + ribavirin, sera was collected prior to treatment, at 3 + 6 months of therapy and 6 months post-treatment. Levels of ICAM-1, VCAM-1 and hyaluronic acid were correlated with alanine aminotransferase levels, HCV-RNA-polymerase chain reaction status and histological fibrosis scoring. RESULTS: A decrease in ICAM-1 levels at 3 and 6 months of therapy, compared with pretreatment levels, was observed in responders to IFN + ribavirin therapy but this decrease in ICAM-1 levels was not evident following cessation of treatment. Hyaluronic acid levels, in both treatment groups, did not differ significantly between responders and non-responders. Hyaluronic acid levels did correlate, significantly, with degree of fibrosis whereas VCAM-1 levels were marginally increased only in patients with moderate (grade III) fibrosis. CONCLUSIONS: Monitoring of VCAM-1 and hyaluronic acid, during antiviral therapy, does not differentiate between responders and non-responders. A decrease in ICAM-1 levels during IFN + ribavirin treatment is associated with response to therapy, and its efficacy in predicting long-term response should be further substantiated.

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Section: Discussioncontrasting

confidence: 99%

Cell adhesion molecules and hyaluronic acid as markers of inflammation, fibrosis and response to antiviral therapy in chronic hepatitis C patients

Granot

Ashur

2001

Mediators of Inflammation

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“…Therapy with ·-IFN led to a marked decrease in serum ICAM-1 concentrations in both groups, but only in ETR patients. This result is in agreement with other reports in the literature [10][11][12][13][14][15][16][17][18] and suggests that ·-IFN is efficacious because it reduces immuno-cell activation and the inflammatory processes.…”

Section: Discussionsupporting

confidence: 93%

“…This expression favours the adhesion of T lymphocytes with surface lymphocyte functionassociated antigen-1 on hepatocytes and may trigger an immune reaction and maintain chronic inflammation [5,6]. Elevated serum levels of a soluble form of ICAM-1 (sICAM-1) have been reported in patients with chronic liver disease of alcoholic [7], autoimmune [8,9] and viral etiology, particularly hepatitis C virus (HCV), as well as changes in these levels after treatment with ·-IFN [10][11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Circulating Intercellular Adhesion Molecule-1 in Chronic Hepatitis C Patients with Normal or Elevated Aminotransferase before and after Alpha-Interferon Treatment

Montalto

Giannitrapani²,

Soresi³

et al. 2003

Intervirology

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Objectives: Intercellular adhesion molecule-1 (ICAM-1) plays a fundamental role during liver inflammation. In fact, weak ICAM-1 expression is physiologically restricted to the endothelium of portal vessels and to sinusoidal lining cells, but it becomes markedly evident on sinusoidal lining cells and at the surface of hepatocytes during inflammatory liver diseases. The aim of this study was to evaluate the behaviour of soluble ICAM-1 (sICAM-1) in chronic hepatitis C (CH-C) patients with persistently normal aminotransferase in comparison with patients with CH-C and elevated aminotransferase, and its changes during α-interferon (IFN) therapy. Immunohistochemical localization of ICAM-1 was also performed on liver tissue specimens of both groups. Methods: Sixty subjects were divided into 3 groups: group A included 19 patients with CH-C and persistently normal aminotransferase; group B included 21 patients with CH-C and persistently elevated aminotransferase levels, and group C included 20 healthy subjects representing the control group. The first two groups were treated with recombinant α-IFN 2b at a dose of 6 MU 3 times a week for 3 months and followed up with 3 MU 3 times a week for another 3 months. Results: Baseline values of serum ICAM-1 in groups A and B were significantly higher than those in group C (p < 0.0001). The median baseline value of sICAM-1 in group A (525.0 ng/ml) was lower than that of group B (561.0 ng/ml), but the difference was not statistically significant. Furthermore, there was a trend toward higher ICAM-1 values as histological severity increased (Mantel-Haenszel χ² 8.8, p < 0.003). Post-treatment sICAM-1 serum values showed a marked decrease in both groups, but only among responder patients, while ICAM-1 levels were unchanged in non-responders. Immunohistochemical localization showed no staining for ICAM-1 in normal liver specimens, while there was a quite similar staining for ICAM-1 in the two groups of patients, consistent with an inflammatory process. Conclusions: This study shows that circulating ICAM-1 levels in most patients with CH-C and persistently normal aminotransferase are higher than those in a control group and the fact that ICAM-1 molecules are also expressed on the hepatocyte membrane suggests that they could play an important role, in association with other molecules, in the intercellular adhesion processes during the induction and maintenance phases of the immune response. In both groups, only patients responding to α-IFN therapy showed a marked decrease in serum ICAM-1 below baseline values.

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“…Then, our findings appear in agreement with literature data and suggest that VCAM-1, which is considered to reflect the degree of liver fibrosis (25,28) and ICAM-1 levels, markers of liver inflammation, have significantly decreased in HCV patients with normal ALT levels following interferon administration (28,42,46,47). However, the relationship between ICAM-1, VCAM-1 and ALT values does not implicate a direct involvement of these adhesion molecules in physiopathology of hepatocellular damage, but it could only reflect the activation of undergoing immunological mechanisms.…”

Section: Discussionsupporting

confidence: 92%

“…While, elevated serum VCAM-1 in chronic hepatitis have been reported by some authors (39,40). Also, many authors confirmed our data related to higher levels of sICAM-1 among patients with chronic HCV-related hepatitis than do control subjects (28,41,42). Moreover, similar results are reported in patients with CLD (34) and CHC (18,25).…”

Section: Discussionsupporting

confidence: 88%

Adhesive molecules and inflammatory markers among hepatitis C virus Saudi patients

Al-Jiffri

2017

Electron J Gen Med

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Background:Currently, about 2% of population are affected with hepatitis C worldwide, chronic hepatitis C (CHC) is the major cause of hepatic cirrhosis and referral for liver transplant. However, there is a high need for noninvasive methods for assessment of hepatocellular damage. Objective: The purpose of this study was to determine the strength of the association between adhesive molecules and inflammatory markers among hepatitis C virus Saudi patients. Methods: One hundred patients with chronic hepatitis C virus infection(64 males and 36 females, their age ranged from 28 to 53 years with circulating anti-HCV antibodies were equally categorized into two study groups: patients with CHC and patients with liver cirrhosis (LC). Also, one fifty healthy subjects were included as healthy controls. Serum alanine aminotransferase (ALT), soluble intercellular adhesion molecule1 (sICAM-1); Soluble vascular adhesion molecule 1(sVCAM-1); Soluble E-selectin(s-E-selectin) and Tumor necrosis factor-alpha (TNF-α) were assayed for all participants. Results: We observed elevation with regard to the healthy controls group in the parameters of ALT, sICAM-1, sVCAM-1, s-E-selectin and TNF-α for patients with CHC and patients with liver cirrhosis (LC). Also, a significant positive correlation between serum TNF-α, sICAM-1, sVCAM-1 and ALT values was detected. Conclusion:In conclusion, our results confirm that, in patients with chronic virus hepatitis and liver cirrhosis there is a significant positive correlation between serum TNF-α, sICAM-1, sVCAM-1 and ALT values. These findings suggest that serum TNF-α levels could be used as a sensitive predictor of liver inflammation, while serum ICAM-1 can be considered as a marker of hepatic necrosis and inflammatory activity in chronic hepatitis, while serum VCAM-1 is an indicator for the severity of liver cirrhosis.

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Serum Intercellular Adhesion Molecule-1 and Long-Term Response to IFN-α2b Therapy in Chronic Hepatitis C

Cited by 4 publications

References 9 publications

Cell adhesion molecules and hyaluronic acid as markers of inflammation, fibrosis and response to antiviral therapy in chronic hepatitis C patients

Cell adhesion molecules and hyaluronic acid as markers of inflammation, fibrosis and response to antiviral therapy in chronic hepatitis C patients

Circulating Intercellular Adhesion Molecule-1 in Chronic Hepatitis C Patients with Normal or Elevated Aminotransferase before and after Alpha-Interferon Treatment

Adhesive molecules and inflammatory markers among hepatitis C virus Saudi patients

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