Serum inhibin A concentration in women with polycystic ovarian syndrome and the correlation to ethnicity, androgens and insulin resistance

Segal, Scott; Elmadjian, Malvina; Takeshige, Takeko; Karp, Steven; Mercado, Ray; Rivnay, Benjamin

doi:10.1016/j.rbmo.2010.02.006

Cited by 9 publications

(14 citation statements)

References 31 publications

(40 reference statements)

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“…Resistin plasma levels have been co rrelated with fasting glucose and HOMAIR in PCOS wo men [60] . Inhibin A levels in PCOS women were not found to correlate with IR in PCOS women [61] . Most of these serum markers share common limitations and have been poorly studied.…”

Section: Assessment Of Insulin Resistancementioning

confidence: 77%

Assessing and treating insulin resistance in women with polycystic ovarian syndrome

Traub¹

2011

WJD

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Polycystic ovarian syndrome (PCOS) is a highly pre valent hormonal and metabolic disorder among repro ductive aged women worldwide. Women with PCOS have widely varying phenotypes and seek medical care for differing reasons. In addition to concern for men strual cycle function, ovulation, hirsutism and acne, many PCOS women have abnormal glucose metabolism. While diabetes mellitus and impaired glucose tolerance are easily diagnosed, the diagnosis of and concern for insulin resistance as a precursor disorder is under appreciated. Insulin resistance may be the first im portant marker of metabolic disease in PCOS women at risk for metabolic syndrome and coronary artery di sease.

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Section: Assessment Of Insulin Resistancementioning

confidence: 77%

Assessing and treating insulin resistance in women with polycystic ovarian syndrome

Traub¹

2011

WJD

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“…Studies conducted with adults have yielded controversial results. While some have shown that INH-A does not change in patients with PCOS (20,21), other studies have shown an increase (22,23,24), while some other studies reported a decrease (25,26,27). Some studies have shown that INH-B level increases in patients with PCOS (28), whereas others have shown that it decreases (30).…”

Section: Discussionmentioning

confidence: 93%

“…However, conflicting results have been reported in studies conducted on adult women. Some studies have shown that INH-A does not change in patients with PCOS (20,21), whereas others have shown that it increases (22,23,24) or decreases (25,26,27). There are also similar controversial results related with INH-B levels (20,21,27,28,29,30).…”

Section: Introductionmentioning

confidence: 99%

Anti-Müllerian Hormone and Inhibin-A, but not Inhibin-B or Insulin-Like Peptide-3, may be Used as Surrogates in the Diagnosis of Polycystic Ovary Syndrome in Adolescents: Preliminary Results

Yetim

Yetim²,

Baş³

et al. 2016

Jcrpe

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Objective:Polycystic ovary syndrome (PCOS) is a common endocrine problem in adolescents with an increasing prevalence of 30%. Pursuing new biomarkers with high specificity and sensitivity in the diagnosis of PCOS in adolescents is currently an active area of research. We aimed to investigate the diagnostic value of anti-Müllerian hormone (AMH), insulin-like peptide-3 (INSL3), inhibin-A (INH-A), and inhibin-B (INH-B) in adolescents with PCOS and also to determine the association, if any, between these hormones and clinical/laboratory findings related with hyperandrogenism.Methods:The study group comprised 53 adolescent girls aged between 14.5 and 20 years who were admitted to our outpatient clinic with symptoms of hirsutism and/or irregular menses and diagnosed as having PCOS in accordance with the Rotterdam criteria. Twenty-six healthy peers, eumenorrheic for at least two years and body mass index-matched, constituted the controls. Fasting blood samples for hormones [luteinizing hormone (LH), follicle-stimulating hormone (FSH), dehydroepiandrosterone-sulfate (DHEAS), androstenedione (D4-A), total/free testosterone (T/fT), sex hormone binding globulin (SHBG), AMH, INSL3, INH-A, INH-B] were drawn after an overnight fast.Results:In the PCOS group, 83% of the subjects were oligomenorrheic/amenorrheic and 87% had hirsutism. The LH, LH/FSH ratio, total T, fT, free androgen-index (FAI), DHEAS levels were significantly higher (p=0.005, p=0.042, p=0.047, p<0.001, p=0.007, p=0.014, respectively) and SHBG was significantly lower (p=0.004) in PCOS patients as compared to the controls. Although the INSL-3 and INH-B levels showed no difference between the groups (p>0.05), AMH and INH-A levels were found to be significantly higher in the PCOS group compared to the controls (p<0.001, p<0.001, respectively). In multiple linear regression analysis, WC SDS (p=0.028), logD4-A (p=0.033), logSHBG (p=0.031), and total ovarian volume (p=0.045) had significant effects on AMH levels, and LH (p=0.003) on INH-A levels. In receiver-operating characteristic analysis, the cut-off values for AMH and INH-A were 6.1 ng/mL (sensitivity 81.1%) and 12.8 pg/mL (sensitivity 86.8%), respectively, to diagnose PCOS. When AMH and INH-A were used in combination, the sensitivity (96.2%) increased.Conclusion:INSL3 and INH-B were not found to have diagnostic value in adolescents with PCOS. On the other hand, it was shown that INH-A could be used as a new diagnostic biomarker in addition to AMH.

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“…In addition to triple test parameters, the quadruple test includes inhibin-A. However, Segal et al found that serum inhibin-A concentration in women with PCOS was lower than normalovulatory women [1,2].In addition, Karsli et al investigated biochemical parameters in the first trimester aneuploidy screening test in the pregnant women with and without PCOS. The biochemical components PAPP-A and fβ-hCG were found to be significantly lower in the PCOS group compared to control group [3].…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Should we change our mind about second trimester biochemical aneuploidy screening markers of patients with polycystic ovary syndrome?

Korkmaz

Kurdoğlu

Ergün

2015

J Endocrinol Invest

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test, it is still used as some patients only present for the first time in the second trimester. Therefore, the quadruple test has started to be used for Down syndrome screening in the second trimester of pregnancy. In addition to triple test parameters, the quadruple test includes inhibin-A. However, Segal et al. found that serum inhibin-A concentration in women with PCOS was lower than normalovulatory women [1,2].In addition, Karsli et al. investigated biochemical parameters in the first trimester aneuploidy screening test in the pregnant women with and without PCOS. The biochemical components PAPP-A and fβ-hCG were found to be significantly lower in the PCOS group compared to control group [3].Although there are studies on human participants in literature about the first trimester aneuploidy screening test to detect Down syndrome, to the best of our knowledge, there have been no studies related to the biochemical parameters in the second trimester aneuploidy screening test in patients with polycystic ovary syndrome. Analysis of the enzymatic steps in the synthesis of estriol, inhibin-A, and the serum levels of biochemical parameters can be recommended for pregnant women with PCOS. These biochemical parameters are also affected by multiple gestation, in vitro fertilization, maternal weight, ethnicity, smoking and parity. The validated software can make adjustments to calculate the risk of Down syndrome for these parameters. PCOS should be added to the parameters. Conflict of interestThe authors declare that they have no competing interests.Ethical approval The manuscript does not require ethics standards. Informed consentThe manuscript does not require informed consent.Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder. Patients with PCOS present with clinical signs of hyperandrogenemia (i.e., hirsutism and acne), menstrual irregularities and infertility. Changes in some enzymatic activities such as 17alphahy-droxylase, 17,20-lyase in the ovary and adrenal gland have been seen in PCOS. Malique et al. also showed that there are differences in the activity of some enzymes which are essential for placental steroid synthesis in patients with PCOS. They detected lower androstenedione and higher estriol concentrations in the cord blood samples of female newborns of women with PCOS. Estriol is synthesized in the placenta and secreted into the maternal circulation in the second trimester. 16 alphahydroxy dehydroepiandrosterone sulphate is formed in the fetal liver by hydroxylation of dehydroepiandrosterone sulphate and is transported to the placenta where it undergoes desulphation by steroid sulphatase and aromatization to estriol. The maternal serum level of unconjugated estriol is lower in Down syndrome pregnancies than in healthy pregnancies in the second trimester. The serum unconjugated estriol level is used as a parameter of the second trimester screening test with serum human chorionic gonadotropin and alphafetoprotein. However, the detection rate of the second trimester screening t...

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Serum inhibin A concentration in women with polycystic ovarian syndrome and the correlation to ethnicity, androgens and insulin resistance

Cited by 9 publications

References 31 publications

Assessing and treating insulin resistance in women with polycystic ovarian syndrome

Assessing and treating insulin resistance in women with polycystic ovarian syndrome

Anti-Müllerian Hormone and Inhibin-A, but not Inhibin-B or Insulin-Like Peptide-3, may be Used as Surrogates in the Diagnosis of Polycystic Ovary Syndrome in Adolescents: Preliminary Results

Should we change our mind about second trimester biochemical aneuploidy screening markers of patients with polycystic ovary syndrome?

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