Serum inflammatory markers and colorectal cancer risk and survival

Ghuman, Sundeep; Hemelrijck, Mieke Van; Garmo, Hans; Holmberg, Lars; Malmström, Håkan; Lambe, Mats; Hammar, Niklas; Walldius, Göran; Jungner, Ingmar; Wulaningsih, Wahyu

doi:10.1038/bjc.2017.96

Cited by 64 publications

(64 citation statements)

References 37 publications

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“…Достоверно более высокие уровни ХС ЛПНП и низкие уровни ХС ЛПВП у пациентов основной группы по сравнению с контрольной, установленные в настоящей работе при исследовании липидного профиля сыворотки крови, согласуются с результатами работы S. Ghuman и соавт. Кроме того, у больных КРР с отдаленными метастазами выявлены достоверно более высокие уровни триглицеридов, ХС ЛПНП и соотношения ХС ЛПНП/ХС ЛПВП по сравнению с пациентами без метастазов [14].…”

Section: Discussionunclassified

“…Если для α-линоленовой (октадекатриеновой) Таблица 3. Содержание видов жирных кислот в мембранах эритроцитов и сыворотке крови у пациентов с колоректальным раком и в группе сравнения (M ± SD), % 8,11,14,17) достоверное (p = 0,007) повышение отмечено только в сыворотке крови, хотя и в мембранах эритроцитов наблюдалась та же тенденция. Для докозатетраеновой 7,10,13,16-22:4 кислоты выявлена инверсная ситуация -уровень ее был достоверно выше в мембранах эритроцитов пациентов с КРР (p <0,0001), а в сыворотке отмечена лишь тенденция к повышению (p = 0,097).…”

Section: экспериментальные статьиunclassified

“…Другой важный аспект изучения состава и роли отдельных ЖК может быть связан с их перспективным использованием в таргетной терапии КРР [1,[7][8][9]. Представлены данные об особенностях состава и уровня ЖК сыворотки и эритроцитов у пациентов с КРР, проживающих в Японии [12,13], Китае [2,14,15], странах Западной Европы [1,7,8], Эти особенности связывают с диетическими традициями, отличиями в образе жизни. Подобная информация о пациентах с КРР, проживающих в Сибири, отсутствует.…”

Section: Introductionunclassified

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Study of the Level of Fatty Acids in Erythrocyte Membranes and Serum of Patients With Colorectal Cancer in Novosibirsk

et al. 2018

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The objectiveis to measure the level of fatty acids in erythrocyte membranes and serum of patients with colorectal cancer.Materials and methods.The study group included 100 patients with diagnosed colorectal cancer (57 men and 43 women). The control group included 24 reasonably healthy people (14 men and 10 women) matched for age and sex, without malignant cancers or manifested pathology of the internal organs.Results.Decreased levels of saturated, monounsaturated fatty acids and increased levels of polyunsaturated fatty acids (PUFAs) in erythrocyte membranes and serum (p <0.0001–0.05) were observed. The levels of omega-3 PUFAs in colorectal cancer exceeded the levels in healthy individuals both in erythrocyte membranes and in serum; for omega-6 PUFAs only a trend was observed. At the same time, the ratio of omega-6/omega-3 PUFAs in colorectal cancer was lower than in control (p <0.0001–0.002). The state of erythrocyte membranes more significantly and for more parameters characterized differences between the groups than serum. The most discriminating parameters between patients with colorectal cancer and healthy individuals both in erythrocyte membranes and serum were the levels of C20:2;11,14 (eicosadienoic), C20:3;8,11,14 (dihomo-γ-linolenic), C20:4;5,8,11,14 (eicosatetraenoic, arachidonic), C22:5;7,10,13,16,19 (docosapentaenoic), and C22:6;4,7,10,13,16,19 (docosahexaenoic) PUFAs.

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Section: Discussionunclassified

Section: экспериментальные статьиunclassified

Section: Introductionunclassified

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Study of the Level of Fatty Acids in Erythrocyte Membranes and Serum of Patients With Colorectal Cancer in Novosibirsk

et al. 2018

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“…Results from previous studies of CRP in relation to CRC and colorectal adenoma risk, including meta-analyses, have been mixed (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Some have been suggestive of a relation between higher CRP levels and increased risk of CRC (7)(8)(9)(10)(11) and colorectal adenoma (12,13), whereas others have been inconclusive (14)(15)(16) or null (17)(18)(19). A large Mendelian randomization study of more than 30,000 CRC cases from three international consortia found no evidence of a causal relation between genetically determined inflammation reflected by CRP and CRC risk (20), while three other studies of CRP-related genetic variants suggested a relation (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

C-reactive Protein and Future Risk of Clinical and Molecular Subtypes of Colorectal Cancer

Bodén

Myte

Harbs

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Inflammation has been implicated in colorectal cancer (CRC) etiology, but the relationship between C-reactive protein (CRP) and CRC risk is unclear. We aimed to investigate the association between pre-diagnostic plasma CRP concentrations and the risk of clinical and molecular CRC subtypes. Methods: We used prospectively collected samples from 1010 matched CRC case-control pairs from two population-based cohorts in Northern Sweden, including 259 with repeated samples. Conditional logistic regression and linear mixed models were used to estimate relative risks of CRC, including subtypes based on BRAF and KRAS mutations, microsatellite instability status, tumor location, stage, lag-time, and (using unconditional logistic regression) BMI. Results: CRP was not associated with CRC risk, regardless of clinical or molecular CRC subtype. For participants with advanced tumors and blood samples <5 years before diagnosis, CRP was associated with higher risk (odds ratio per 1 unit increase in natural logarithmtransformed (ln) CRP 1.32, 95% CI 1.01-1.73). CRP levels increased over time, but average time trajectories were similar for cases and controls (P interaction =0.19). Conclusions: Our results do not support intertumoral heterogeneity as an explanation for previous inconsistent findings regarding the role of CRP in CRC etiology. The possible association in the subgroup with advanced tumors and shorter follow-up likely reflects undiagnosed cancer at baseline. Impact: Future efforts to establish the putative role of chronic, low-grade inflammation in CRC development will need to address the complex relationship between systemic inflammatory factors and tumor microenvironment, and might consider larger biomarker panels than CRP alone.

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“…Reports have established a link between host inflammatory response and oncologic outcomes . Furthermore, cancer patients often present with elevated peripheral blood cell numbers, acute‐phase proteins and decreased total albumin levels .…”

Section: Introductionmentioning

confidence: 99%

Systemic inflammation score is a prognostic marker after curative resection in gastric cancer

Weng

Chen³

et al. 2019

ANZ Journal of Surgery

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Background The systemic inflammation score (SIS), as calculated from preoperative serum albumin level and lymphocyte‐to‐monocyte ratio, has been demonstrated to be a prognostic marker in cancer. The present study intended to investigate the prognostic role of SIS in gastric cancer patients after curative gastrectomy in comparison with other prognostic markers. Methods Preoperative SIS was retrospectively calculated in patients who underwent curative gastrectomy between 2007 and 2011 in Fudan University Shanghai Cancer Center. The prognostic accuracy of each score was compared utilizing time‐dependent receiver operating characteristics analysis. Results The higher SIS score was associated with older age, larger tumour size, a more advanced tumour‐nodes‐metastasis stage and lymph node status, deeper tumour invasion, the presence of lymphovascular invasion and a poorer overall survival and disease‐free survival. In time‐dependent receiver operating characteristics analysis, the SIS had a higher area under the curve for the prediction of 5‐year overall survival than the neutrophil lymphocyte ratio. The SIS maintained the predictive accuracy superiority throughout the observation period. Conclusion The SIS is a useful prognostic marker in gastric cancer patients after curative gastrectomy.

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Serum inflammatory markers and colorectal cancer risk and survival

Cited by 64 publications

References 37 publications

Study of the Level of Fatty Acids in Erythrocyte Membranes and Serum of Patients With Colorectal Cancer in Novosibirsk

Study of the Level of Fatty Acids in Erythrocyte Membranes and Serum of Patients With Colorectal Cancer in Novosibirsk

C-reactive Protein and Future Risk of Clinical and Molecular Subtypes of Colorectal Cancer

Systemic inflammation score is a prognostic marker after curative resection in gastric cancer

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