Serum Immunoglobulins in Patients with Iron Deficiency Anemia

Sadeghian, Mohammad Hadi; Keramati, Mohammad Reza; Ayatollahi, Hossein; Manavifar, Lida; Enaiati, Hoda; Mahmoudi, Masoumeh

doi:10.1007/s12288-010-0025-3

Cited by 15 publications

(15 citation statements)

References 20 publications

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“…Some reports indicate iron depletion may be responsible for decreased HMI while others did not report any change in serum immunoglobulin in iron deficiency anemia (IDA). [ 4 6 12 13 ] We therefore, designed this study to establish the altered status of these parameters in iron deficient children at baseline and at 3 months post iron supplementation therapy.…”

Section: Introductionmentioning

confidence: 99%

Impact of iron deficiency anemia on cell-mediated and humoral immunity in children: A case control study

et al. 2014

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Objective:The precise role of iron in immune regulation especially in children vulnerable to iron deficiency is not fully known. Hence, this study was conducted to evaluate the effects of iron deficiency anemia (IDA) and its treatment with oral iron supplementation on cell-mediated immunity (CMI) and humoral immunity (HMI) in children.Materials and Methods:A total of 40 children (<15 years) with IDA and 40 age-matched healthy children after satisfying the inclusion criteria were enrolled for this case-control study. Flow cytometric evaluation of absolute and relative numbers of cluster of differentiation 4 (CD4) and CD8 (cluster of differentiation 8) lymphocyte subgroups was carried out to assess the CMI and serum Immunoglobulin G (IgG), Immunoglobulin A (IgA), Immunoglobulin M (IgM) were measured to assess the HMI at baseline and 3 months post oral iron supplementation.Results:Significantly lower levels (P < 0.05) of CD4+ T-cells and decreased CD4:CD8 ratios were observed in the iron deficient children. Iron supplementation significantly improved the CD4+ cell counts and CD4:CD8 ratios. However, immunoglobulin levels weren’t different between the two groups.Conclusions:Although IDA did not influence HMI, it significantly impaired CMI, which was improved following iron supplementation for 3 months.

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Section: Introductionmentioning

confidence: 99%

Impact of iron deficiency anemia on cell-mediated and humoral immunity in children: A case control study

et al. 2014

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“…It was concluded that IL-6 is affected by iron deficiency. 7,8 Reza Keramati M et al investigated lymphocyte subsets in pre-menopausal women with iron-deficiency anaemia; 50 normal subjects and 50 IDA (hypochromic microcytic) cases were enrolled. Experimental and control anticoagulated blood samples were evaluated using flow cytometry to determine the absolute and relative numbers of various lymphocyte subgroups.…”

Section: Discussionmentioning

confidence: 99%

Lymphocytic Count in Premenopausal Women with Iron Deficiency Anemia

Khanna¹

2019

IJCMR

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Introduction: Iron deficiency anemia (IDA) is the most common nutritional deficiency worldwide. It can cause reduced work capacity in adults and impact motor and mental development in children and adolescents. Aim of the current research was to study the lymphocytic count in premenopausal women with iron deficiency anemia. Material and methods: The study was conducted in the Department of General Pathology of the medical institution. For the study, we selected 100 pre-menopausal women between the age group of 18-40 years who were diagnosed with iron deficiency anemia and their hemoglobin level was less than 10 g/dL. 100 pre-menopausal women with normal hemoglobin level were recruited after matching with the subjects for control group. The patients with thalassemia, leukemia or any other chronic and autoimmune disease were excluded from the study. Laboratory evaluation of each subject was done. Results: The mean age of the patients in study group was 32.67 years and in control group was 34.58 years. There were 100 subjects in each group. Table 2 shows the mean lymphocyte count in peripheral venous blood in pre-menopausal women with Iron deficiency anemia and normal healthy women. The mean CD3+, CD4+, CD8+, and CD19+ lymphocyte counts were 1.66, 0.71, 0.66, 0.41, 1.18 X 10 9 /L, respectively, in study group, and 1.82, 0.59, 0.81, 0.31 and 1.59 X 10 9 /L, respectively, for the control group. Conclusion: Within the limitations of the study, this can be concluded that significant change in seen in the lymphocyte count in premenopausal women with iron deficiency anemia.

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“…Many bodily systems are affected by anaemia, including the immune system (3), and deterioration of cell-mediated immune functions, as well as decreased levels of circulating peripheral blood T lymphocytes as a consequence of iron deficiency, has been shown in some studies (4). Although human immunoglobulin levels are not decreased in iron deficiency (5), animal studies have shown that the humoral response is quite altered (6). Macrophages play an important role in nonspecific immunity and, with the contribution of polymorphonuclear leukocytes, represent a primary defence before the activation of both cell-mediated and humoral immunity.…”

Section: Introductionmentioning

confidence: 99%

Iron Deficiency Anaemia is Associated with Decreased Levels of Macrophage Migration Inhibitory Factor and Monocyte Chemoattractant Protein-1

et al. 2015

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Many bodily systems are affected by iron deficiency anaemia (IDA), including the immune system. However, the pathophysiological mechanisms whereby this anaemia promotes deterioration in immunity remain largely unexplained. In order to enlighten this pathophysiological link , serum levels of macrophage migration inhibitory factor (MIF) and monocyte chemoattractant protein-1 (MCP-1), which play an important roles in a healthy functioning immune system, were examined in patients with IDA and healthy volunteers. A total of 30 patients with IDA (mean age 33.6±7.8 years, 30% male) and 30 healthy individuals (mean age 30.1 ± 8.8 years, 27 % male) were included. Serum MIF and MCP-1 levels were measured in a sandwich-assay format, using commercial enzyme-linked immunosorbent assay kits. There was no statistically significant difference in age and gender distribution between participants with IDA and controls (p>0.05). Serum MIF and MCP-1 concentrations were lower in the IDA group than in the control group (p < 0.005, and p < 0.01, respectively). When considering the role of MIF and MCP-1 in maintaining the normal immune response of the organism, a decrease in production in patients with IDA may contribute to immune dysfunction in these individuals.

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Serum Immunoglobulins in Patients with Iron Deficiency Anemia

Cited by 15 publications

References 20 publications

Impact of iron deficiency anemia on cell-mediated and humoral immunity in children: A case control study

Impact of iron deficiency anemia on cell-mediated and humoral immunity in children: A case control study

Lymphocytic Count in Premenopausal Women with Iron Deficiency Anemia

Iron Deficiency Anaemia is Associated with Decreased Levels of Macrophage Migration Inhibitory Factor and Monocyte Chemoattractant Protein-1

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