Impact of iron deficiency anemia on cell-mediated and humoral immunity in children: A case control study

Das, Ira; Kaushik, Sushmita; Mukhopadhyay, Debanjan; Roy, Sumedha; Raychaudhuri, Gargi; Chatterjee, Mitali; Mitra, Pinaki

doi:10.4103/0976-9668.127317

Cited by 56 publications

(35 citation statements)

References 13 publications

(24 reference statements)

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“…Our results showed insignificant alteration in the percentage and the absolute count of CD8 positive lymphocytes. This is in agreement with Das et al, [ 20 ] and Mullick et al, [ 21 , 22 ]. While Thibault et al, [ 23 ] found a decreased in the IL-2 production in IDA patients which was explained by alteration in CD8 positive lymphocyte maturation.…”

Section: Discussionsupporting

confidence: 94%

Assessment of peripheral blood lymphocyte subsets in children with iron deficiency anemia

et al. 2018

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BackgroundIron plays an important role in body defense and essential for normal immune system development where its deficiency may result in an inadequate immune response. We aimed to assess the lymphocyte subsets in childhood iron deficiency anemia (IDA) with their laboratory correlations.MethodsFifty IDA (< 18 years) and 25 age and sex-matched healthy children were enrolled and a complete history was obtained and clinical examination was performed. Complete blood count, serum iron, total iron binding capacity and serum ferritin, were performed. Flow cytometric determination of peripheral blood CD3+, CD4+, CD8+ T-lymphocytes and CD19+ B-lymphocytes and CD4/CD8 ratio were done.ResultsPatients had significantly lower hemoglobin, Serum iron, ferritin levels and higher lymphocytic count in patients compared with controls (p = 0.001, 0.03, 0.001, 0.001 respectively). CD3 count and percentage were significantly lower in IDA patients compared to controls (p = 0.007 and 0.005 respectively).There was a Significant reduction in the CD4 count, percentage and CD4/CD8 ratio in patients compared with controls (p = 0.001, 0.001 and 0.005 respectively) while there was no significant difference regarding CD8 count and percentage. No significant difference between the two studied groups regarding either CD19 count or percentage (p = 0.28 and 0.18 respectively) were found.ConclusionsIDA is associated with impaired cell-mediated immune response specifically T-cell mediated immunity.

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Section: Discussionsupporting

confidence: 94%

Assessment of peripheral blood lymphocyte subsets in children with iron deficiency anemia

et al. 2018

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“…In addition, VitD in combination with the two drugs can participate in the regulation of Th1/Th2 cytokine. That will further regulate the alveolar macrophages, pulmonary epithelial cells and dendritic cells to inhibit the production of IL-4 and IL-6 cells, reducing airway inflammation and promoting the secretion of IL-2 and IFN-γ that prevents the reoccurrence of airway hyper-responsiveness ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

Correlation between the vitamin D levels and asthma attacks in children: Evaluation of the effects of combination therapy of atomization inhalation of budesonide, albuterol and vitamin D supplementation on asthmatic patients

et al. 2017

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The aim of the present study was to analyze the correlation between the vitamin D (VitD) levels and asthma attack in children, and to evaluate the effects of combination therapy of atomization inhalation of budesonide, albuterol and VitD supplementation on asthmatic children. The total sample size comprised of 96 children with asthma from the time period between May 2015 to April 2016. At the same time, 96 healthy children were also selected from the physical examination center for comparison study. The levels of serum VitD in both groups were detected by the enzyme-linked immunosorbent assay (ELISA). Pulmonary function index that includes the measurement of FEV1, FVC, FEV1/FVC, MEF25 and MEF50 were performed to analyze the results. The patients in the control group were treated with only the budesonide therapy and the patients in the observation group were treated with atomization inhalation of budesonide combined with salbutamol and VitD supplementation. After the treatment, the levels of inflammatory cell indicators (IL-2, IL-4, IL-6 and IFN-γ) and pulmonary function in the two groups were compared. The levels of serum VitD in the children with asthma were significantly lower than those in the normal children. The serum IgE level in children with asthma was significantly higher than that in the normal children (P<0.05). Pearson correlation coefficient analyses showed that VitD levels were not correlated with FEV1, FVC and FEV1/FVC levels (P>0.05), but was positively correlated with MEF25 and MEF50 (P<0.05). After the treatment, the levels of IL-2 and IFN-γ in the observation group were significantly higher and levels of IL-4 and IL-6 were significantly lower than those in the control group (P<0.05). The pulmonary function (FEV1, FVC, FEV1/FVC, MEF25 and MEF50) of the observation group was better than that of the control group (P<0.05). The serum VitD levels of children with asthma were closely related to the acute asthmatic attacks. The lower the levels of serum VitD further leads to higher possibility of asthmatic attacks. Atomization inhalation of budesonide combined with albuterol and VitD supplementation can significantly improve the inflammatory response of the children with asthma.

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“…Blood loss due to menstruation [ 39 ], sub-optimal nutrition and pregnancy [ 40 ] could possibly contribute to these age patterns in women. Das et al recently found that iron deficiency was associated with lower CD4 T cell counts in children in India [ 41 ]. Notably, we did not find an association of CD4 T cell counts with either RBC counts or Hgb levels.…”

Section: Discussionmentioning

confidence: 99%

Sex and Urbanicity Contribute to Variation in Lymphocyte Distribution across Ugandan Populations

et al. 2016

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Management of patient care and interpretation of research data require evaluation of laboratory results in the context of reference data from populations with known health status to adequately diagnose disease or make a physiological assessment. Few studies have addressed the diversity of lymphocyte subsets in rural and urban Ugandan populations. Here, 663 healthy blood bank donors from semi-urban centers of Kampala consented to participate in a study to define lymphocyte reference ranges. Whole blood immunophenotyping was performed to determine the frequency and absolute counts of T, B, and NK cells using clinical flow cytometry. Results from blood bank donors were compared to a rural cohort from the district of Kayunga and more urban clinical trial participants from the capital city, Kampala. Relationships between hematological and lymphocyte parameters were also explored. In the semi-urban blood donors, females were significantly different from males in all parameters except the frequency of CD8 T and B cells. Females had higher absolute counts of CD4 T, CD8 T and B cells, whereas males had higher NK cell counts. NK cell frequency and counts were significantly higher in semi-urban blood donors, regardless of sex, compared to more urban study participants. CD8 T cell frequency and counts were significantly higher in the blood donors compared to the rural participants, irrespective of sex. Interestingly, basophil counts were positively associated with overall T cell counts. These findings suggest that both sex and level of cohort urbanicity may influence lymphocyte subset distributions in Ugandans.

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Impact of iron deficiency anemia on cell-mediated and humoral immunity in children: A case control study

Cited by 56 publications

References 13 publications

Assessment of peripheral blood lymphocyte subsets in children with iron deficiency anemia

Assessment of peripheral blood lymphocyte subsets in children with iron deficiency anemia

Correlation between the vitamin D levels and asthma attacks in children: Evaluation of the effects of combination therapy of atomization inhalation of budesonide, albuterol and vitamin D supplementation on asthmatic patients

Sex and Urbanicity Contribute to Variation in Lymphocyte Distribution across Ugandan Populations

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