Serum immunoglobulin G, M, and IgG : IgM ratio as predictors for outcome of childhood nephrotic syndrome

Bahbah, Mohammad Nasser Hamed Mahmoud; Mashad, Ghada M El; Abdelnaby, Sameh Abdallah; Azab, Hassnaa Mahmoud

doi:10.4103/1110-2098.163897

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…Concomitant administration of RA with DOX adjusts neurotoxicity biomarkers. [54] In addition, RA improved the brain histological alterations caused by DOX in agreement with Ref. 55.…”

Section: Discussionsupporting

confidence: 85%

Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin‐induced neurotoxicity in rats

Rizk

Masoud

Maher

2017

J Biochem & Molecular Tox

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Doxorubicin (DOX) is a chemotherapeutic agent widely used in human malignancies. Its long-term use cause neurobiological side effects. The aim of the present study was to investigate the prophylactic effect exerted by daily administration of ellagic acid (EA) and rosmarinic acid (RA) on DOX-induced neurotoxicity in rats. Our data showed that DOX-induced significant elevation of brain malondialdehyde, tumor necrosis factor-alpha (TNF-α), inducible nitric oxide synthase (iNOS), caspase-3, and cholinesterase associated with significant reduction in reduced glutathione, monoamines namely serotonin, dopamine, as well as norepinephrine. Concomitant administration of EA (10 mg/kg/day, p.o. for 14 days) and/or RA (75 mg/kg/day, p.o. for 14 days) with DOX significantly mitigated the neural changes induced by DOX. Meanwhile, treatment ameliorated pro-inflammatory cytokines as TNF-α, iNOS, and attenuated oxidative stress biomarkers as well as brain monoamines. In conclusion, EA and RA can effectively protect against DOX-induced neurotoxicity, and the mechanisms underlying the neuroprotective effect are potentially associated with its antioxidant, anti-inflammatory, and antiapoptotic properties.

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“…Concomitant administration of RA with DOX adjusts neurotoxicity biomarkers. [54] In addition, RA improved the brain histological alterations caused by DOX in agreement with Ref. 55.…”

Section: Discussionsupporting

confidence: 85%

Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin‐induced neurotoxicity in rats

Rizk

Masoud

Maher

2017

J Biochem & Molecular Tox

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“…It is related to the disorder of T cell and secondary disorder of B-cell that leads to changes in scales of immunoglobulins. 1 This systemic disturbance of function of T cell results in the production of humoral factors or lymphokines that responsible for the rise of permeability of the glomerular basement membrane. 2 Usually, children are more commonly affected, with a decreased quality of life, so they may expose to serious complications related to considerable morbidity and mortality rates.…”

Section: Introductionmentioning

confidence: 99%

Tumor Necrosis Factor Alpha-863 C/A Single Nucleotide Polymorphisms and Nephrotic Syndrome

Abbas¹,

Fadhil²,

Ali³

2020

ijddt

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Introduction: Cytokines act as a mediator of inflammation in childhood nephrotic syndrome. Polymorphisms of cytokines genes may influence susceptibility to nephrotic syndrome (NS), as well as, patients’ steroid responses. Objective: To study the association of tumor necrosis factor-alpha single nucleotide polymorphisms (TNF-α SNP) (-863 C/A) with the development of NS in addition to access to their effects on serum level of TNF and the response to steroid therapy. Patients and Methods: This study included 60 patients (19 female and 41 male) with nephrotic syndrome; their ages ranged from 2 to 18 years. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to assess the TNF-α gene polymorphism. Results: According to the digestion pattern of RFLP-PCR products of TNF-α-863, this polymorphism had three genotypes, which were CC, CA, and AA, in both NS patients and controls. Also, the current result observed that -863 SNP do not affect the serum level of TNF-α and steroid responsiveness in patients with nephrotic syndrome. Conclusion: This polymorphism did not show any significant association with response to steroid therapy and TNF serum level neither at genotype nor at allele level.

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Serum immunoglobulin G, M, and IgG : IgM ratio as predictors for outcome of childhood nephrotic syndrome

Cited by 2 publications

References 4 publications

Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin‐induced neurotoxicity in rats

Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin‐induced neurotoxicity in rats

Tumor Necrosis Factor Alpha-863 C/A Single Nucleotide Polymorphisms and Nephrotic Syndrome

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