Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin‐induced neurotoxicity in rats

Rizk, Hanan A.; Masoud, Marwa A.; Maher, Omar W.

doi:10.1002/jbt.21977

Cited by 44 publications

(22 citation statements)

References 64 publications

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“…RosA could effectively prevent DOX-induced neurotoxicity, and the underlying mechanism of neuroprotection was possibly related to its antioxidant, anti-inflammatory, and anti-apoptotic effects. (Rizk et al, 2017) Spinal cord injury RosA prevented the rise in the SCI-induced nuclear localization of NF-kB and the corresponding reduction in the nuclear localization of Nrf-2. RosA inhibited neuronal apoptosis through targeting ROS and inflammatory responses in SCI.…”

Section: Effect Of Rosmarinic Acid On Other Inflammatory Diseasesmentioning

confidence: 98%

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

et al. 2020

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Inflammatory diseases are caused by abnormal immune responses and are characterized by an imbalance of inflammatory mediators and cells. In recent years, the antiinflammatory activity of natural products has attracted wide attention. Rosmarinic acid (RosA) is a water-soluble phenolic compound that is an ester of caffeic acid and 3, 4dihydroxyphenyl lactic acid. It is discovered in many plants, like those of the Boraginaceae and Lamiaceae families. RosA has a wide range of pharmacological effects, including antioxidative, anti-apoptotic, anti-tumorigenic, and anti-inflammatory effects. The antiinflammatory effects of RosA have been revealed through in vitro and in vivo studies of various inflammatory diseases like arthritis, colitis, and atopic dermatitis. This article mainly describes the preclinical research of RosA on inflammatory diseases and depicts a small amount of clinical research data. The purpose of this review is to discuss the antiinflammatory effects of RosA in inflammatory diseases and its underlying mechanism.

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Section: Effect Of Rosmarinic Acid On Other Inflammatory Diseasesmentioning

confidence: 98%

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

et al. 2020

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“…Hydroxyl radicals and superoxide radicals along with hydrogen peroxide are produced after administration of DOX, leading to the alterations of oxidative stress and antioxidant defense system. It is assumed that the formation of free radicals induces oxidative stress and plays a crucial role in the mechanism of DOX-induced neurotoxicity [ 12 , 13 ]. Moreover, the generation of superoxide anions induced by DOX can elevate the level of circulating necrosis factor-alpha (TNF- α ) which can directly cross the blood-brain barrier and activate glial cells to initiate the local production of proinflammatory cytokines, exacerbating oxidative stress and neural apoptosis [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of dl‐3‐n‐Butylphthalide against Doxorubicin‐Induced Neuroinflammation, Oxidative Stress, Endoplasmic Reticulum Stress, and Behavioral Changes

Liao

Xiang

Dang

et al. 2018

Oxidative Medicine and Cellular Longevity

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Doxorubicin (DOX) is a broad-spectrum antitumor drug while its use is limited due to its neurobiological side effects associated with depression. We investigated the neuroprotective efficacy of dl-3-n-butylphthalide (dl-NBP) against DOX-induced anxiety- and depression-like behaviors in rats. dl-NBP was given (30 mg/kg) daily by gavage over three weeks starting seven days before DOX administration. Elevated plus maze (EPM) test, forced swimming test (FST), and sucrose preference test (SPT) were performed to assess anxiety- and depression-like behaviors. Our study showed that the supplementation of dl-NBP significantly mitigated the behavioral changes induced by DOX. To further explore the mechanism of neuroprotection induced by dl-NBP, several biomarkers including oxidative stress markers, endoplasmic reticulum (ER) stress markers, and neuroinflammatory cytokines in the hippocampus were quantified. The results showed that dl-NBP treatment alleviated DOX-induced neural apoptosis. Meanwhile, DOX-induced oxidative stress and ER stress in the hippocampus were significantly ameliorated in dl-NBP pretreatment group. Our study found that dl-NBP alleviated the upregulation of malondialdehyde (MDA), nitric oxide (NO), CHOP, glucose-regulated protein 78 kD (GRP-78), and caspase-12 and increased the levels of reduced glutathione (GSH) and activities of catalase (CAT), glutathione reductase (GR), and glutathione peroxidase (GPx) in the hippocampus of rats exposed to DOX. Additionally, the gene expression of interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-alpha (TNF-α) and protein levels of inducible nitric oxide synthase (iNOS) were significantly increased in DOX-treated group, whereas DOX-induced neuroinflammation was significantly attenuated in dl-NBP supplementation group. In conclusion, dl-NBP could alleviate DOX-induced anxiety- and depression-like behaviors via attenuating oxidative stress, ER stress, inflammatory reaction, and neural apoptosis, providing a basis as a therapeutic potential against DOX-induced neurotoxicity.

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“…Rizk et al demonstrated the prophylactic effects of EA (10 mg/kg/day, orally) on doxorubicin‐induced neurotoxicity in rats. They reported that EA strikingly attenuates the levels of MDA, TNF‐a, iNOS, caspase‐3, while increases the levels of GSH and monoamines namely serotonin, dopamine, and norepinephrine in the brain following doxorubicin‐induced neurotoxicity (Rizk, Masoud, & Maher, ). In another study, EA (17.5 and 35 mg/kg) improved the cognitive deficits and GSH content, while alleviated TBARS and TNF‐α levels in the brain of streptozotocin‐induced memory deficit rats (Bansal, Yadav, & Kumar, ).…”

Section: Resultsmentioning

confidence: 99%

“…Rizk et al demonstrated the prophylactic effects of EA (10 mg/kg/ day, orally) on doxorubicin-induced neurotoxicity in rats. They reported that EA strikingly attenuates the levels of MDA, TNF-a, iNOS, caspase-3, while increases the levels of GSH and monoamines namely serotonin, dopamine, and norepinephrine in the brain following doxorubicin-induced neurotoxicity (Rizk, Masoud, & Maher, 2017).…”

Section: In Vitro Studiesmentioning

confidence: 99%

Antiinflammatory and anti‐cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies

Rahimi

Ghadiri

Ramezani

et al. 2020

Phytotherapy Research

123

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Inflammation is commonly characterized as a defensive and protective reaction of the body to various exogenous or endogenous stimuli, which aims to maintain the body health. Punica granatum (pomegranate) and its constituent ellagic acid (EA) are recently more taken into accounts since their promising pharmacological effects. Therefore, we aimed to obtain a comprehensive review regarding antiinflammatory, anticancer, and antioxidant activities of both pomegranate and EA and their possible involved mechanisms. In the procedure, scientific databases, including Web of Science, PubMed, Scopus, and Google Scholar, were searched in the English language, until the end of January 2019. Pomegranate belonging to the Punicaceae has been used for medical purposes from ancient and in different cultures. Several studies have also supported that EA is the major active compound of pomegranate and possesses antimutagenic, antiinflammatory, antifibrosis, anticancer, and antiaging properties. It has been suggested that pomegranate and EA possess promising immunomodulatory effects in preclinical models as well as human studies through regulation of the T‐cell function and suppressing humoral immunity. Hopefully, we wish that this review and information could be helpful for designing further experiments to investigate the potential protective effects of pomegranate and EA.

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Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin‐induced neurotoxicity in rats

Cited by 44 publications

References 64 publications

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

Neuroprotective Effects of dl‐3‐n‐Butylphthalide against Doxorubicin‐Induced Neuroinflammation, Oxidative Stress, Endoplasmic Reticulum Stress, and Behavioral Changes

Antiinflammatory and anti‐cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies

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