Serum IL-22 correlates with psoriatic severity and serum IL-6 correlates with susceptibility to phototherapy

Lo, Yuan-Hsin; Torii, Kan; Saito, Chieko; Furuhashi, Takuya; Maeda, Akira; Morita, Akimichi

doi:10.1016/j.jdermsci.2010.03.018

Cited by 75 publications

(58 citation statements)

References 10 publications

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“…Increased serum IL-22 production also has been found in several autoimmune diseases such as psoriasis and CD [14,18]. However, in patients with SLE, decreased serum and plasma IL-22 production were showed by our groups and Cheng et al, respectively [19,20].…”

Section: Discussionmentioning

confidence: 46%

Expressions of IL-22 in circulating CD4+/CD8+ T cells and their correlation with disease activity in SLE patients

et al. 2011

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Recently, Th17 cell-associated responses have received growing attention; however, the role of IL-22 (a cytokines also produced by Th17 cells) in the pathogenesis of systemic lupus erythematosus (SLE) has not been widely explored. In this study, we analyze the frequencies of IL-22-positive CD4+/CD8+ T cells in peripheral blood mononuclear cells (PBMCs) from patients with SLE and their correlations with disease activity and clinical data. Five-color flow cytometry (FCM) was used to assess IL-22 production of CD4+/CD8+ T cells in PBMCs from 31 patients with SLE and 22 healthy control subjects, following stimulation ex vivo with phorbol 12-myristate 13-acetate and ionomycin for 4 h. Results showed that the percentages of IL-22-positive CD4+ T cells were increased in the PBMCs of patients with SLE compared with healthy control subjects, whereas there were no significant differences in the percentages of IL-22-positive CD8+ T cells. There was a strong positive correlation between the proportion of CD4+ T cells expressing IL-22 and SLEDAI score (r (s) = 0.65, P < 0.001). Furthermore, the frequencies of IL-22-positive CD4+ T cells were significantly higher in patients with SLE with nephritis than those without nephritis (Z = -2.72, P < 0.01). In conclusion, increased frequencies of IL-22-positive CD4+ T cells in patients with SLE and positive correlation with SLEDAI score and lupus nephritis suggest that this cytokine may be implicated in the pathogenesis of the disease.

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Section: Discussionmentioning

confidence: 46%

Expressions of IL-22 in circulating CD4+/CD8+ T cells and their correlation with disease activity in SLE patients

et al. 2011

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“…Increased levels of Th17 cells and their associated cytokines including IL-23, IL-17, and IL-22 have been found in human psoriatic skin (6,11,12). Elevated IL-22 concentrations were measured in plasma from patients and IL-22 production correlated positively with severity of the disease and negatively with response to therapy suggesting a significant role of this cytokine in psoriasis (5,7,13). T lymphocytes appeared to represent a major source of IL-22 in skin lesions (7) and treatment with cyclosporine A downregulated both IL-17 and IL-22 expression in those patients (14).…”

mentioning

confidence: 99%

IL-22 Is Required for Imiquimod-Induced Psoriasiform Skin Inflammation in Mice

Belle

Heusch

Lemaire

et al. 2012

The Journal of Immunology

256

234

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Psoriasis is a common chronic autoimmune skin disease of unknown cause that involves dysregulated interplay between immune cells and keratinocytes. IL-22 is a cytokine produced by the TH1, TH17, and TH22 subsets that are functionally implicated in the psoriatic pathology. We assessed the role of IL-22 in a mouse model where psoriasiform skin inflammation is triggered by topical application of the TLR7/8 agonist imiquimod. At the macroscopic level, scaly skin lesions induced by daily applications of imiquimod in wild-type mice were almost totally absent in IL-22–deficient mice or in mice treated with a blocking anti–IL-22 Ab. At the microscopic level, IL-22–deficient mice showed a dramatic decrease in the development of pustules and a partial decrease in acanthosis. At the molecular level, the absence or inhibition of IL-22 strongly decreased the expression of chemotactic factors such as CCL3 and CXCL3 and of biomarkers such as S100A8, S100A7, and keratin 14, which reflect the antimicrobial and hyperproliferative responses of keratinocytes. IL-22 also played a major role in neutrophil infiltration after imiquimod treatment. IL-23 was required for IL-22 production, and γδ TCR lymphocytes represented the major source of IL-22 in lymph nodes from imiquimod-treated mice. However, T cells were not absolutely required for IL-22 production because imiquimod-induced IL-22 expression in the skin is still preserved in Rag2−/− mice. Taken together, our data show that IL-22 is required for psoriasis-like lesions in the mouse imiquimod model and is produced by both T cells and innate immune cells.

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“…IL-6 and IL-8 both were found to be positive in our skin tissue and it accords with previously known data as these interleukins have been found in high levels in active psoriasis patients, both skin and serum samples. The serum level of IL-6 has also been described as a good predictor for the successful topical therapy outcome as it prevents from immunosupression [2,4,9].…”

Section: Discussionmentioning

confidence: 99%

Distribution of human B-defensin 2, TNF-alpha, IL-1 alpha, IL-6 and IL-8 in psoriatic skin

Mozeika

Pilmane

Ķīsis

2012

PoA

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Psoriasis is a chronic, inflammatory, proliferative condition of the skin, clinically characterized by red, scaly plaques. Psoriasis has a large and heterogenous genetic and immunologic background with the dysregulation of the host defense system. The human keratinocytes obtained from psoriasis lesions are a very rich source to various antimicrobial peptides. Both Th 17 and Th 1 pathways play a role in the pathogenesis of psoriasis. Our aim of the study was to evaluate the expression of human beta defensin 2 and TNF alpha in correlation with interleukins 1 alpha, 6 and 8 in the skin biopsies of psoriatic lesions.We evaluated 14 Psoriasis vulgaris patients' skin samples. Skin biopsies were obtained using a routine punch method. All the tissue specimens were stained with hematoxylin and eosin and by immunohistochemistry for human beta defensin 2, TNF-alpha, IL-1 alpha, IL-6 and IL-8. We graded the intensity of staining semiquantitatively.We observed intraepithelial lymphocytes, marked the diffuse intradermal infiltrates of inflammatory cells, the inflammatory cells in the hair follicle, surrounding sweat glands and subepithelial blood vessels. Defensin-containing and TNF-alpha positive cells were found in all the skin samples: defensin-containing cells varied from few to abundant positive structures in the visual field and TNF-alpha positive cells varied from few to numerous positive structures in the visual field. IL-1 alpha expressed poorly, while IL-6 positive cells were found in the range from few positive to the abundance of positive structures in the visual field and IL-8 positive structures varied from numerous positive structures to the abundance of positive structures in the visual field. E. Mozeika, M. Pilmane, J. KisisWe conclude that IL-6, IL-8 and TNF-alpha are most common cytokines for psoriatic skin lesions. A moderate number of structures expresses the antimicrobial protein defensin in the psoriatic skin.

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Serum IL-22 correlates with psoriatic severity and serum IL-6 correlates with susceptibility to phototherapy

Cited by 75 publications

References 10 publications

Expressions of IL-22 in circulating CD4+/CD8+ T cells and their correlation with disease activity in SLE patients

Expressions of IL-22 in circulating CD4+/CD8+ T cells and their correlation with disease activity in SLE patients

IL-22 Is Required for Imiquimod-Induced Psoriasiform Skin Inflammation in Mice

Distribution of human B-defensin 2, TNF-alpha, IL-1 alpha, IL-6 and IL-8 in psoriatic skin

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