Serum hs-CRP Levels are Increased in de Novo Parkinson's Disease Independently from Age of Onset

Song, In‐Uk; Cho, Hyun-Ji; Kim, Jung-Seok; Park, In-Seok; Lee, Kwang‐Soo

doi:10.1159/000363570

Cited by 20 publications

(21 citation statements)

References 31 publications

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“…Available evidence shows that chronic inflammation is instrumental to its pathogenesis . This is supported by findings that serum CRP levels are significantly higher in older adults with Parkinson's disease compared with healthy controls . Parkinson's disease patients with higher CRP tended to be older and have a higher incidence of CVD .…”

Section: Crp and Ageing‐related Diseasementioning

confidence: 88%

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C‐reactive protein and ageing

Tang

Fung

et al. 2017

Clin Exp Pharma Physio

103

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SummaryIncreasing evidence shows that C-reactive protein (CRP) is not only an inflammatory biomarker but also an important risk factor associated with ageing-related diseases including cardiovascular disease, hypertension, diabetes mellitus, and kidney disease.Recent studies have demonstrated that CRP is pathogenic in a number of diseases including hypertensive cardiovascular and kidney complications, diabetic nephropathy, and acute and chronic kidney diseases. It is well known that CRP binds its receptor, CD32/CD64, to induce the process of inflammation by activating the NF-κB signalling pathway. In addition, CRP mediates tissue fibrosis in a number of cardiovascular and kidney diseases by activating TGF-β/Smad signalling via TGF-β1-dependent and independent mechanisms. Furthermore, CRP is able to activate mTOR signalling in the diabetic conditions. Our recent studies also revealed that CRP impairs cell regeneration by causing the G1 cell cycle arrest and promotes ageing via a Smad3-dependent

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Section: Crp and Ageing‐related Diseasementioning

confidence: 88%

“…In the current literature, the common ageing‐related diseases and conditions associated with increased CRP levels include CVD, hypertension, diabetes mellitus, chronic kidney injury, Alzheimer's disease and Parkinson's disease …”

Section: Crp and Ageing‐related Diseasementioning

confidence: 99%

C‐reactive protein and ageing

Tang

Fung

et al. 2017

Clin Exp Pharma Physio

103

View full text Add to dashboard Cite

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“…CRP is considered a biomarker of aging and chronic illness and/or chronic low grade inflammation [ 40 ]. In fact, in subjects affected by cardiovascular diseases, myocardial infarction, stroke [ 41 - 43 ], hypertension [ 44 , 45 ], type-2 diabetes [ 46 ], chronic kidney injury [ 47 , 48 ], cancer or Alzheimer's disease and Parkinson's disease [ 49 - 51 ], increased CPR levels have been reported in an age-dependent manner [ 52 ]. Comparing ageing adults with or without diseases/disability, CPR levels are reported higher in those with some physical illnesses [ 52 ].…”

Section: Introductionmentioning

confidence: 99%

Protein-C Reactive as Biomarker Predictor of Schizophrenia Phases of Illness? A Systematic Review

Orsolini

Sarchione

Vellante

et al. 2018

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BackgroundSchizophrenia is a complex illness in which genetic, environmental, and epigenetic components have been implicated. However, recently, psychiatric disorders appear to be related to a chronic inflammatory state, at the level of specific cerebral areas which have been found as well impaired and responsible for schizophrenia symptomatology. Hence, a role of inflammatory mediators and cytokines has been as well defined. Accordingly, the role of an acute inflammatory phase protein, the C-reactive protein (CRP) has been recently investigated.ObjectiveThe objective of the present study is to evaluate how PCR may represent a biomarker in schizophrenia, i.e. correlated with illness phases and/or clinical manifestation and/or psychopathological severity.MethodsA systematic review was here carried out by searching the following keywords ((C-reactive protein AND ((schizophrenia) OR (psychotic disorder))) for the topics ‘PCR’ and ‘Schizophrenia’, by using MESH terms.ResultsAn immune dysfunction and inflammation have been described amongst schizophrenic patients. Findings reported elevated CRP levels in schizophrenia, mainly correlated with the severity of illness and during the recrudescent phase. CRP levels are higher when catatonic features, negative symptomatology and aggressiveness are associated. CRP levels appeared not to be related to suicidal behaviour and ideation.ConclusionCRP and its blood levels have been reported higher amongst schizophrenic patients, by suggesting a role of inflammation in the pathogenesis of schizophrenia. Further studies are needed to better understand if CRP may be considered a biomarker in schizophrenia.

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“…Additionally, dystrophic microglia have been identified in DLB [ 24 ]. Age-related changes in microglia have also been suggested to play a role in Parkinson’s disease [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Model Senescent Microglia Induce Disease Related Changes in α-Synuclein Expression and Activity

Angelova

Brown

2018

Biomolecules

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Aging is the most prominent risk factor for most neurodegenerative diseases. However, incorporating aging-related changes into models of neurodegeneration rarely occurs. One of the significant changes that occurs in the brain as we age is the shift in phenotype of the resident microglia population to one less able to respond to deleterious changes in the brain. These microglia are termed dystrophic microglia. In order to better model neurodegenerative diseases, we have developed a method to convert microglia into a senescent phenotype in vitro. Mouse microglia grown in high iron concentrations showed many characteristics of dystrophic microglia including, increased iron storage, increased expression of proteins, such as ferritin and the potassium channel, Kv1.3, increased reactive oxygen species production and cytokine release. We have applied this new model to the study of α-synuclein, a protein that is closely associated with a number of neurodegenerative diseases. We have shown that conditioned medium from our model dystrophic microglia increases α-synuclein transcription and expression via tumor necrosis factor alpha (TNFα) and mediated through nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). The conditioned medium also decreases the formation of α-synuclein tetramers, associated ferrireductase activity, and increases aggregates of α-synuclein. The results suggest that we have developed an interesting new model of aged microglia and that factors, including TNFα released from dystrophic microglia could have a significant influence on the pathogenesis of α-synuclein related diseases.

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Serum hs-CRP Levels are Increased in de Novo Parkinson's Disease Independently from Age of Onset

Cited by 20 publications

References 31 publications

C‐reactive protein and ageing

C‐reactive protein and ageing

Protein-C Reactive as Biomarker Predictor of Schizophrenia Phases of Illness? A Systematic Review

Model Senescent Microglia Induce Disease Related Changes in α-Synuclein Expression and Activity

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