Serum High Molecular Weight Adiponectin is Associated with Mild Renal Dysfunction in Japanese Adults

Kawamoto, Ryuichi; Tabara, Yasuharu; Kohara, Katsuhiko; Miki, Tetsuro; Abe, Masanori; Kusunoki, Tomo; Katoh, Tateaki; Ohtsuka, Nobuyuki

doi:10.5551/jat.5124

Cited by 10 publications

(15 citation statements)

References 39 publications

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“…Our results are in agreement with previous reports demonstrating higher levels of circulating adiponectin are associated with reduced renal function (Kawamoto et al 2010; Kruger et al 2011). Consistent with these associations, endothelial cell adiponectin is also inversely associated with renal function.…”

Section: Discussionsupporting

confidence: 94%

“…There are also reports of an inverse relation of circulating adiponectin with adiposity and glucose, and a direct relation with HDL cholesterol (Belalcazar et al 2012; Cnop et al 2003). Interestingly, higher circulating adiponectin has also been linked with decreased renal function (Kawamoto et al 2010; Kruger et al 2011) and markers of anemia (red blood cell count, hematocrit, and hemoglobin) (Aso et al 2009; Aso et al 2012; Kawamoto et al 2011). However, it is not known whether endothelial cell adiponectin is similarly related with these factors and with circulating adiponectin levels.…”

Section: Introductionmentioning

confidence: 99%

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Higher levels of adiponectin in vascular endothelial cells are associated with greater brachial artery flow-mediated dilation in older adults

Yoo

Hwang

Luttrell

et al. 2015

Experimental Gerontology

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Adiponectin, an adipocyte-derived protein, exerts anti-atherosclerotic effects on the vascular endothelium. Recently adiponectin protein has been reported in murine vascular endothelial cells, however, whether adiponectin is present in human vascular endothelial cells remains unexplored. We sought to examine 1) adiponectin protein in vascular endothelial cells collected from older adults free of overt cardiovascular disease; 2) the relation between endothelial cell adiponectin and in vivo vascular endothelial function; and 3) the relation between endothelial cell adiponectin, circulating (plasma) adiponectin and related factors. We measured vascular endothelial function (brachial artery flow-mediated dilation using ultrasonography), vascular endothelial cell adiponectin (biopsy coupled with quantitative immunofluorescence) and circulating adiponectin (Mercodia, ELISA) in older, sedentary, non-smoking, men and women (55 – 79 years). We found that higher endothelial cell adiponectin was related with greater flow-mediated dilation (r=0.43, P<0.05) and greater flow-mediated dilation normalized for shear stress (r=0.56, P<0.01), but was not related with vascular smooth muscle responsiveness to nitric oxide (r=0.04, P=0.9). Vascular endothelial cell adiponectin was not related with circulating adiponectin (r=−0.14, P=0.6). Endothelial cell and circulating adiponectin were differentially associated with adiposity, metabolic and other factors, but both were inversely associated with renal function (r=0.44 to 0.62, P ≤ 0.04). In conclusion, higher endothelial cell adiponectin levels are associated with higher vascular endothelial function, independent of circulating adiponectin levels in older adults.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Higher levels of adiponectin in vascular endothelial cells are associated with greater brachial artery flow-mediated dilation in older adults

Yoo

Hwang

Luttrell

et al. 2015

Experimental Gerontology

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“…The role of adiponectin in kidney disease is complex, 48 and elevated adiponectin levels have been shown to be associated with better renal function among men with diabetes in the Health Professionals Follow-up Study, 49 and in an adult Japanese community-based population. 50 A few epidemiologic studies have shown that adiponectin levels are lower in subjects with cardiovascular events, in some cases predicting events independently of established risk factors. [4][5][6] Adiponectin levels were reduced in intracranial atherosclerosis versus other stroke etiologies 51 and correlated inversely with carotid intima media thickness.…”

Section: Gardener Et Almentioning

confidence: 99%

Serum Adiponectin in Relation to Race–Ethnicity and Vascular Risk Factors in the Northern Manhattan Study

Gardener

Crisby

Sjoberg

et al. 2013

Metabolic Syndrome and Related Disorders

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Background: Population-based data on serum adiponectin levels, an adipocytokine secreted from adipose tissue, are lacking, particularly across race-ethnic groups. Studies have suggested an inverse association between adiponectin and vascular risk factors, but data are limited and inconsistent. We examined the cross-sectional association between adiponectin, vascular risk factors and race-ethnicity in the population-based Northern Manhattan Study (NOMAS). Methods: Blood samples, anthropomorphics, and vascular risk factors were collected at baseline. Multivariable linear regression analysis was conducted with log-transformed adiponectin as the dependent variable. Results: Adiponectin was measured among 2900 participants (age 69 -10 years, body mass index (BMI) 28.0 -5.6, 37% male, 21% white, 53% Hispanic, 24% black). The mean adiponectin was 11.4 -6.2 mg/mL (median = 9.8, range = 2.1-53.3). After multivariable adjustment, adiponectin levels were greatest among whites, followed by Hispanics, and lowest among blacks. Lower adiponectin levels were observed in participants with the following characteristics: Male, former smoking, hypertension, diabetes, homeostasis model assessment of insulin resistance (HOMA-IR), metabolic syndrome, moderate alcohol use, elevated waist circumference, BMI, estimated glomerular filtration rate (eGFR), triglycerides, low-density lipoprotein cholesterol (LDL-C), lower high-density lipoprotein cholesterol (HDL-C), and younger age. Obesity was a stronger risk factor for decreased adiponectin among blacks than among whites or Hispanics. The associations for several vascular risk factors, including hypertension, triglycerides, and low HDL-C, with low adiponectin were stronger among individuals who were not obese than among those who were obese. Conclusions: Adiponectin levels were lower among blacks and Hispanics and among those with various vascular risk factors, and greater with older age. The association between BMI and adiponectin varied across raceethnic groups. Investigation of whether differences in body fat distribution may explain race-ethnic differences in adiponectin is needed.

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“…However, studies linking adiponectin and renal function have been conducted in persons with existing disorders such as CKD, diabetes and coronary disease and the results were inconsistent and contradictory [27][28][29][30][31][32] . To our knowledge, there are four studies linking adiponectin and renal function in healthy persons [33][34][35][36] and again, the results were inconsistent and contradictory. In the current study of healthy elderly women, eGFR, regardless of the method to estimate GFR, was inversely associated with serum adiponectin.…”

Section: As Shown Inmentioning

confidence: 99%

Anemia and Reduced Renal Function are Independent Predictors of Elevated Serum Adiponectin in Elderly Women

Tsuboi

Watanabe

Kazumi

et al. 2013

JAT

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Aim: Although higher adiponectin levels predict a low risk of type 2 diabetes, elevated adiponectin levels predict higher mortality in older persons. Methods: We examined the associations of adiponectin with anthropometric, metabolic and hematological variables and renal function in 361 community-dwelling elderly women aged 76±8. Renal function was assessed using the estimated glomerular filtration rate (eGFR).

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Serum High Molecular Weight Adiponectin is Associated with Mild Renal Dysfunction in Japanese Adults

Abstract: Conclusions:We conclude that a higher serum HMW adiponectin level is associated with a reduced odds ratio of mild renal dysfunction in Japanese adults.

Cited by 10 publications

References 39 publications

Higher levels of adiponectin in vascular endothelial cells are associated with greater brachial artery flow-mediated dilation in older adults

Higher levels of adiponectin in vascular endothelial cells are associated with greater brachial artery flow-mediated dilation in older adults

Serum Adiponectin in Relation to Race–Ethnicity and Vascular Risk Factors in the Northern Manhattan Study

Anemia and Reduced Renal Function are Independent Predictors of Elevated Serum Adiponectin in Elderly Women

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