Serum Adiponectin in Relation to Race–Ethnicity and Vascular Risk Factors in the Northern Manhattan Study

Gardener, Hannah; Crisby, Milita; Sjoberg, Charlotte; Hudson, Barry I.; Goldberg, Ronald; Mendez, Armando J.; Wright, Clinton B.; Rundek, Tatjana; Elkind, Mitchell S.V.; Sacco, Ralph L.

doi:10.1089/met.2012.0065

Cited by 29 publications

(24 citation statements)

References 64 publications

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“…NHB youth have significantly lower adiponectin concentrations compared with their white peers irrespective of adiposity (7,8,29). Studies of HMWA reveal similar racial/ethnic contrasts in adults (21). In line with these observations, the current study showed that NHB youth with type 2 diabetes had significantly lower total adiponectin and HMWA concentrations at the time of randomization in TODAY even after adjusting for the higher BMI in NHB.…”

Section: Resultsmentioning

confidence: 99%

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Adiponectin, Insulin Sensitivity, β-Cell Function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY

et al. 2016

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OBJECTIVEThe Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) study demonstrated that glycemic failure rates in the three treatments combined—metformin plus rosiglitazone, metformin alone, and metformin plus lifestyle—were higher in non-Hispanic blacks (NHB; 52.8%) versus non-Hispanic whites (NHW; 36.6%) and Hispanics (H; 45.0%). Moreover, metformin alone was less effective in NHB versus NHW versus H youth. This study describes treatment-associated changes in adiponectin, insulin sensitivity, and β-cell function over time among the three racial/ethnic groups to understand potential mechanism(s) responsible for this racial/ethnic disparity.RESEARCH DESIGN AND METHODSTODAY participants underwent periodic oral glucose tolerance tests to determine insulin sensitivity, C-peptide index, and oral disposition index (oDI), with measurements of total and high-molecular-weight adiponectin (HMWA).RESULTSAt baseline NHB had significantly lower HMWA than NHW and H and exhibited a significantly smaller increase (17.3% vs. 33.7% vs. 29.9%, respectively) during the first 6 months overall. Increases in HMWA were associated with reductions in glycemic failure in the three racial/ethnic groups combined (hazard ratio 0.61, P < 0.0001) and in each race/ethnicity separately. Over time, HMWA was significantly lower in those who failed versus did not fail treatment, irrespective of race/ethnicity. There were no differences in treatment-associated temporal changes in insulin sensitivity, C-peptide index, and oDI among the three racial/ethnic groups.CONCLUSIONSHMWA is a reliable biomarker of treatment response in youth with type 2 diabetes. The diminutive treatment-associated increase in HMWA in NHB (∼50% lower) compared with NHW and H may explain the observed racial/ethnic disparity with higher therapeutic failure rates in NHB in TODAY.

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Section: Resultsmentioning

confidence: 99%

“…To probe the metabolic/hormonal mechanism(s) potentially responsible for the racial/ethnic disparity in therapeutic failure rates in TODAY, we targeted 1 ) adiponectin because it is known to vary by race/ethnicity (7–9,21) and 2 ) insulin sensitivity and β-cell function because of the well-established racial/ethnic contrast (2–5,22). …”

Section: Resultsmentioning

confidence: 99%

Adiponectin, Insulin Sensitivity, β-Cell Function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY

et al. 2016

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“…For example, Caucasians have a higher level of adiponectin than other ethnicities such as Asians or African Americans [13,53]. In a multiethnic study, Morimoto et al reported significant ethnic differences in the level of leptin, adiponectin, IL-6 and CRP between Caucasians, Japanese Americans, Latinos, African Americans and Native Hawaiians [17].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of circulating adipokines and hsCRP association with cardiovascular disease risk factors and metabolic syndrome in Arabs

Abu‐Farha

Behbehani

Elkum

2014

Cardiovasc Diabetol

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BackgroundCardiovascular diseases (CVD) are a leading cause of death worldwide including the Middle East. This is caused in part by the dysregulation of adipose tissue leading to increased production of pro-inflammatory adipokines and reduction in cardio-protective adipokines such as adiponectin. Ethnicity has been recognized as a major factor in the association between CVD risk factors and the different circulating adipokines. In this study, for the first time, the relationship between traditional cardiovascular risk factors, Metabolic Syndrome (MetS) and circulating level of adipokines in Arab ethnicity was investigated.MethodsWe conducted a population-based cross-sectional survey on 379 adult Arab participants living in Kuwait. Traditional cardiovascular risk factors such as blood pressure (BP), low density lipoprotein (LDL) and triglyceride (TG) were measured. Plasma levels of circulating Leptin, Plasminogen Activator Inhibitor (PAI-1) visfatin, adiponectin, resistin and adipsin were assessed using the multiplexing immunobead-based assay.ResultsCirculating levels of High sensitivity C-Reactive Protein (hsCRP), Leptin, PAI-1 and adiponectin were significantly higher in Arab women than men (p < 0.0001). In multi-variate analysis, the homeostasis model assessment-insulin resistance (HOMA-IR) and body mass index (BMI) showed strong association with most of the biomarkers (p < 0.05). HsCRP showed significant association with all risk factors (p < 0.05). Leptin, PAI-1 and adipsin showed significant positive correlation with BMI, unlike adiponectin which showed inverse correlation (p < 0.05). Subjects in the highest tertile of leptin, PAI-1 and hsCRP had higher odds of having Metabolic Syndrome (MetS) (odd ratio [OR] = 3.02, 95% confidence interval [CI] = 1.47 – 6.19) and (OR = 2.52, 95% CI = 1.45 – 4.35), (OR = 4.26, 95% CI = 2.39 – 7.59) respectively. On the other hand subjects with highest tertile of adiponectin had lower odds of having MetS (OR = 0.22, 95% CI = 0.12 – 0.40). Leptin, PAI-1 and hsCRP showed significant positive association with increased MetS components (P-trend <0.05), while adiponectin was negatively associated with increased MetS components (P-trend <0.0001).ConclusionOur results show positive association between hsCRP, leptin, PAI-1 with increased MetS components and increase the odds of having MetS. Adiponectin on the other hand showed inverse correlation with MetS components and associated with reduction in MetS. Overall, our data highlights the significant clinical value these markers have in MetS especially hsCRP which can be used as good marker of low grade inflammation in Arabs.

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“…22 The populations where adiponectin as marker were investigated were from various ethnic groups. 12,[23][24][25] There is a need to evaluate adiponectin levels in Indian population as there is limited population based evidence among Indians during the progression of normoglycemic to hyperglycemic condition. A recent study done by Mohan et al indicated profiling of serum adiponectin in healthy, IGT, and diabetic individuals.…”

Section: Discussionmentioning

confidence: 99%

Adiponectin and IL-6

et al. 2013

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These authors contributed equally to this work. Keywords: inflammation, adipokines, prediabetic, biomarkerAim: The objective of the study was to identify the association if any, of inflammatory markers (adiponectin and IL-6) with fasting glucose in normoglycemic (healthy), prediabetic (impaired fasting glucose), and hyperglycemic (diabetic) people in Indian population.Methods: Total 162 volunteers were distributed into 3 groups (normoglycemic, individuals with impaired fasting glucose, and hyperglycemic) as per aDa criterion. The blood chemistry parameters were analyzed and serum adiponectin and IL-6 levels were measured by eLIsa.Results: significant reduction was observed in serum adiponectin level in hyperglycemic and impaired fasting glucose population compared with normoglycemic population. significant reduction in adiponectin was also observed in impaired fasting glucose group compared with hyperglycemic group. similarly significant increase was also observed in IL-6 level in hyperglycemic and impaired fasting glucose groups compared with normoglycemic group.Conclusions: From our data it can be summarized that there is a significant change in both adiponectin (reduction) and IL-6 (increase) levels in normoglycemic (healthy), prediabetic (impaired fasting glucose), and hyperglycemic (diabetic) population in Indian population. There is a significant but gradual change during the progression of healthy toward diabetic population via pre-diabetic condition.

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Serum Adiponectin in Relation to Race–Ethnicity and Vascular Risk Factors in the Northern Manhattan Study

Cited by 29 publications

References 64 publications

Adiponectin, Insulin Sensitivity, β-Cell Function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY

Adiponectin, Insulin Sensitivity, β-Cell Function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY

Comprehensive analysis of circulating adipokines and hsCRP association with cardiovascular disease risk factors and metabolic syndrome in Arabs

Adiponectin and IL-6

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