Serum hepatocyte growth factor levels in hepatectomized and nonhepatectomized surgical patients

Tomiya, Tomoaki; Tani, Masayoshi; Yamada, Shinwa; Hayashi, Shigeki; Umeda, Noritsugu; Fujiwara, Kenji

doi:10.1016/0016-5085(92)91186-8

Cited by 94 publications

(59 citation statements)

References 23 publications

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“…8) HGF elevation occurs postoperatively due to surgical injury near the cancer lesion or in normal tissues. [11][12][13] Blood HGF concentration increases in patients who have Fig. 4 Comparison of disease-free interval between high HGF patients and low HGF patients after lung surgery.…”

Section: Survival Analysismentioning

confidence: 99%

“…There was a significant difference between groups (log rank test, P = 0.020). HGF: hepatocyte growth factor undergone major surgery or inflammation 10,12) or patients suffering from Systemic Inflammatory Reaction Syndrome 11) or pancreatitis. 13) According to in vivo models, tumor metastasis to the lung may be enhanced by normal tissue injury.…”

Section: Survival Analysismentioning

confidence: 99%

“…7) Additionally, some investigators have reported that HGF production is caused by several types of tissue damage. [9][10][11][12][13] Surgical injury itself may be a trigger for cytokine production or HGF conversion by HGF activator. Several in vitro studies have revealed that HGF activation results from elevated IL-6 expression.…”

Section: Introductionmentioning

confidence: 99%

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Plasma Hepatocyte Growth Factor Elevation May Be Associated with Early Metastatic Disease in Primary Lung Cancer Patients

Hosoda

Hayashi

Tukada

et al. 2012

ATCS

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Purpose: Hepatocyte growth factor (HGF), a ligand of the c-met proto-oncogene, exhibits activating effects on human lung cancer both in vitro and in vivo. However, few studies have reported the correlations between concentration changes of blood HGF and postsurgical prognosis. Methods: We evaluated whether surgery-related blood HGF elevation has prognostic significance in patients with surgically resected non-small cell lung cancer. We examined blood HGF concentration, c-met expression, and postoperative prognosis of 25 cases of primary resected, non-small cell lung cancer. Results: We divided the patients into 2 groups according to receiver operating characteristics curve analysis using 7.2 ng/mL as the cut-off value of blood HGF concentration. Survival curve analysis revealed that patients with a high level of HGF (over the cutoff value) exhibited a poor prognosis of metastatic disease, compared to those in the low-level group after curative surgery (log rank test, P = 0.020; Wilcoxon test, P = 0.016). Conclusion: Elevation of HGF in plasma may be an important prognostic factor for early metastatic disease in patients with primary lung cancer. Moreover, inhibition of HGF elevation may have therapeutic effects on early distant metastasis of lung cancer.

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Section: Survival Analysismentioning

confidence: 99%

Section: Survival Analysismentioning

confidence: 99%

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Plasma Hepatocyte Growth Factor Elevation May Be Associated with Early Metastatic Disease in Primary Lung Cancer Patients

Hosoda

Hayashi

Tukada

et al. 2012

ATCS

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“…53 Furthermore, infusion of human recombinant HGF into rats following 2-AAF treatment results in the expansion of several liver cell populations, including the hepatic stellate cells and oval cells. 52 Evidently, this situation also occurs in humans, as elevated levels of serum HGF are present in individuals with chronic hepatitis and cirrhosis, [55][56][57] both conditions in which oval cell proliferation is well documented. 7,18,38,40,58,59 In situ hybridization has revealed that oval cells and basophilic hepatocytes, in addition to hepatic stellate cells, express aFGF transcripts.…”

Section: Role Of Hepatic Stellate Cellsmentioning

confidence: 99%

Oval cell‐mediated liver regeneration: Role of cytokines and growth factors

Lowes

Croager

Olynyk

et al. 2002

J of Gastro and Hepatol

153

123

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In experimental models, which induce liver damage and simultaneously block hepatocyte proliferation, the recruitment of a hepatic progenitor cell population comprised of oval cells is invariably observed. There is a substantial body of evidence to suggest that oval cells are involved in liver regeneration, as they differentiate into hepatocytes and biliary cells. Recently, bone marrow cells were shown to be a source of a stem cells with the capacity to repopulate the liver. Presently, the relationship between bone marrow cells and oval cells is unclear. Investigations will be greatly assisted by the availability of in vitro models based on a knowledge of cytokines that affect oval cells. While the cytokines, which regulate the different hematopoietic lineages, are well characterized, there is relatively little information regarding those that influence oval cells. This review outlines recent developments in the field of oval cell research and focuses on cytokines and growth factors that have been implicated in regulating oval cell proliferation and differentiation.

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“…All these receptors contain a tyrosine kinase domain in their intracellular portion that autophosphorylates the receptor for activation. The TNF effect may be intracellular on receptor tyrosine kinase or extracellular through cross-talk between TNF and [52][53][54] showed that the level of TGF-␣ in blood may be a good indicator of liver growth and correlates better than HGF levels with the extent of the regenerative response. However, it is not known whether growth factor production in LDLT is adequate for optimal growth of the donor and recipient livers.…”

Section: Basic Mechanisms Of Liver Regeneration After Phmentioning

confidence: 99%