Liver regeneration: From laboratory to clinic

Fausto, Nelson

doi:10.1053/jlts.2001.27865

Cited by 126 publications

(123 citation statements)

References 88 publications

(106 reference statements)

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“…The regeneration of this organ is linked to the development of several pathologies including cirrhosis, fibrosis, and hepatocellular carcinomas. 1,54 It will be important to review and investigate the role of TIMPs in these human diseases. …”

Section: Discussionmentioning

confidence: 99%

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Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration

et al. 2005

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Section: Discussionmentioning

confidence: 99%

“…1 The liver has a remarkable capacity to regulate its growth and mass and to regenerate upon loss or damage. Differentiated, mature hepatocytes re-enter the cell cycle but stop proliferating upon restoration of liver mass.…”

mentioning

confidence: 99%

Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration

et al. 2005

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“…During liver regeneration, not only do the levels of proteins promoting cell proliferation (HGF, NF-κB, cyclin D1, cyclin E) increase, but also the genes inhibiting apoptosis (Bcl-2) are coordinately activated. This effectively results in enhanced cell proliferation and reduced cell death [55]. Livers in rats in which TGF-β is overexpressed and cell proliferation is inhibited cannot regenerate after partial hepatectomy [56], indicating that enhanced cell proliferation and reduced apoptosis is of high importance for liver regeneration.…”

Section: Coordination Of Cell Proliferation and Cell Death In Size Comentioning

confidence: 99%

Molecular mechanism of size control in development and human diseases

Yang

2011

Cell Res

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How multicellular organisms control their size is a fundamental question that fascinated generations of biologists. In the past 10 years, tremendous progress has been made toward our understanding of the molecular mechanism underlying size control. Original studies from Drosophila showed that in addition to extrinsic nutritional and hormonal cues, intrinsic mechanisms also play important roles in the control of organ size during development. Several novel signaling pathways such as insulin and Hippo-LATS signaling pathways have been identified that control organ size by regulating cell size and/or cell number through modulation of cell growth, cell division, and cell death. Later studies using mammalian cell and mouse models also demonstrated that the signaling pathways identified in flies are also conserved in mammals. Significantly, recent studies showed that dysregulation of size control plays important roles in the development of many human diseases such as cancer, diabetes, and hypertrophy.

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“…In this context, the adult liver, having the extensive capability of maintaining parenchymal cell number throughout the life span of the organism, can be considered as a single lineage stem cell system in which the hepatocyte itself is the stem cell. 2 Since 1990, it was proposed that stem cells include the following three categories: actual stem cells, potential stem cells, and committed stem cells. 3 A typical example of committed stem cells are hepatocytes that appear to be normally quiescent, but can be activated to produce progeny whose only differentiation option is hepatocytic cells.…”

Section: Introductionmentioning

confidence: 99%

“…3 A typical example of committed stem cells are hepatocytes that appear to be normally quiescent, but can be activated to produce progeny whose only differentiation option is hepatocytic cells. 2,4 The ability of the human body to self-repair and replace the cells and tissues of some organs is often evident (as in the case of the skin). It has been estimated that complete renewal of liver tissue takes place in about a year.…”

Section: Introductionmentioning

confidence: 99%

Pluripotent plasticity of stem cells and liver repopulation

Gennero

Roos

Sperber

et al. 2010

Cell Biochemistry & Function

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Different types of stem cells have a role in liver regeneration or fibrous repair during and after several liver diseases. Otherwise, the origin of hepatic and/or extra-hepatic stem cells in reactive liver repopulation is under controversy. The ability of the human body to self-repair and replace the cells and tissues of some organs is often evident. It has been estimated that complete renewal of liver tissue takes place in about a year. Replacement of lost liver tissues is accomplished by proliferation of mature hepatocytes, hepatic oval stem cells differentiation, and sinusoidal cells as support. Hepatic oval cells display a distinct phenotype and have been shown to be a bipotential progenitor of two types of epithelial cells found in the liver, hepatocytes, and bile ductular cells. In gastroenterology and hepatology, the first attempts to translate stem cell basic research into novel therapeutic strategies have been made for the treatment of several disorders, such as inflammatory bowel diseases, diabetes mellitus, celiachy, and acute or chronic hepatopaties. In the future, pluripotent plasticity of stem cells will open a variety of clinical application strategies for the treatment of tissue injuries, degenerated organs. The promise of liver stem cells lie in their potential to provide a continuous and readily available source of liver cells that can be used for gene therapy, cell transplant, bio-artificial liver-assisted devices, drug toxicology testing, and use as an in vitro model to understand the developmental biology of the liver.

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Liver regeneration: From laboratory to clinic

Cited by 126 publications

References 88 publications

Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration

Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration

Molecular mechanism of size control in development and human diseases

Pluripotent plasticity of stem cells and liver repopulation

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