Serum hepatitis B surface antigen levels correlate with high serum HBV DNA levels in patients with chronic hepatitis B: A cross-sectional study

Gupta, Ekta; Kumar, Ashish; Choudhary, Aashish; Kumar, Manoj; Sarin, S.K.

doi:10.4103/0255-0857.96664

Cited by 25 publications

(42 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is consistent with our findings that HBe Ag positive patients had a significant higher median level (range) of HBV-DNA load in comparison to HBe Ag negative patients. This is in agreement with Gupta et al, (2012) who found that HBV DNA load is higher in HBe antigen-positive than in HBe antigen-negative patients.…”

Section: Resultssupporting

confidence: 93%

Occult and Chronic Hepatitis B Infection: Relation of Viral Load to Serum Level of 25 Hydroxy Vitamin D

Mashaly¹,

Sayed²,

Shaker³

et al. 2016

Int.J.Curr.Microbiol.App.Sci

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 93%

Occult and Chronic Hepatitis B Infection: Relation of Viral Load to Serum Level of 25 Hydroxy Vitamin D

Mashaly¹,

Sayed²,

Shaker³

et al. 2016

Int.J.Curr.Microbiol.App.Sci

View full text Add to dashboard Cite

“…Given the invasiveness of the liver biopsy procedure, it has become important to develop novel, non-invasive strategies to diagnose fibrosis. Median HBsAg levels have been shown to fluctuate through the different stages of HBV infection (7,9,16) and serum HBsAg levels were shown to correlate with HBV DNA levels (17). However, there is limited information describing the association between HBsAg and liver pathology in patients with CHB who are in the IC phase (18).…”

Section: Introductionmentioning

confidence: 99%

Serum HBsAg and HBeAg levels are associated with liver pathological stages in the immune clearance phase of hepatitis B virus chronic infection

Zeng

Liu

Dong

et al. 2015

Molecular Medicine Reports

View full text Add to dashboard Cite

Abstract.The association between hepatitis B surface antigen (HBsAg) and hepatitis B 'e' antigen (HBeAg) levels and liver inflammation and fibrosis in patients with chronic hepatitis B (CHB) in the immune clearance (IC) remains elusive. The aim of the present study was to investigate whether HBsAg and HBeAg levels were associated with liver inflammation and fibrosis in CHB patients during the IC phase. Kendall's rank correlation analysis and receiver operating characteristic curves were used to determine the correlation between HBsAg, HBeAg and liver pathological stages. Multivariate analysis by forward logistic regression was used to analyze significant predictors of cirrhosis. A liver pathology-predicting model (IC model), which used routinely assessed markers in combination with HBsAg and HBeAg levels, was constructed. There were significantly positive correlations between the HBsAg and HBeAg levels (γ= 0.317, P<0.001), and between the HBsAg and HBV-DNA levels (γ=0.489, P<0.001). However, there was no correlation between the HBsAg and alanine aminotransferase levels. HBsAg and HBeAg levels differed significantly at various liver pathological stages and declined progressively in advanced liver pathological stages. Multivariate logistic regression analysis showed that age, HBsAg and HBeAg levels as well as the international normalized ratio (INR) were independent predictors of liver fibrosis during the IC phase. The IC model had a specificity and sensitivity of 88.64 and 78.24%, respectively, a positive predictive value of 48.15% and negative predictive value of 96.79%. In conclusion, HBsAg and HBeAg levels were negatively and indirectly correlated with liver inflammation and fibrosis in CHB patients in the IC phase. The IC model reliably predicted the probability of liver cirrhosis.

show abstract

“…[4][5][6] Various clinical applications of qHBsAg have been described. [7][8][9][10][11] It has been demonstrated that the combined use of qHBsAg…”

Section: Introductionmentioning

confidence: 99%

Correlation between two chemiluminescence based assays for quantification of hepatitis B surface antigen in patients with chronic hepatitis B infection

Gupta

Pandey

Kumar

et al. 2015

Indian Journal of Medical Microbiology

Self Cite

View full text Add to dashboard Cite

show abstract

Serum hepatitis B surface antigen levels correlate with high serum HBV DNA levels in patients with chronic hepatitis B: A cross-sectional study

Abstract: Serum HBsAg correlates with HBV DNA in CHB patients, especially in high serum HBV DNA, HBe antigen-positive and treatment-naïve group. HBsAg levels can be used for predicting high serum HBV DNA levels.

Cited by 25 publications

References 22 publications

Occult and Chronic Hepatitis B Infection: Relation of Viral Load to Serum Level of 25 Hydroxy Vitamin D

Occult and Chronic Hepatitis B Infection: Relation of Viral Load to Serum Level of 25 Hydroxy Vitamin D

Serum HBsAg and HBeAg levels are associated with liver pathological stages in the immune clearance phase of hepatitis B virus chronic infection

Correlation between two chemiluminescence based assays for quantification of hepatitis B surface antigen in patients with chronic hepatitis B infection

Contact Info

Product

Resources

About