Serum heat shock protein 70 levels are decreased in normal human pregnancy

Molvarec, Attila; Rigó, János; Nagy, Bálint; Walentin, Szilvia; Szalay, J; Füst, George; Karádi, István; Prohászka, Zoltán

doi:10.1016/j.jri.2006.12.002

Cited by 46 publications

(42 citation statements)

References 43 publications

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“…Both thee mechanisms are associated with HSP70 induction (Gebhardt et al 1999;Wang et al 1996). Consistent with our presumptions, Molvarec et al (2007bMolvarec et al ( , 2010 demonstrated that serum HSP70 concentrations are decreased in normal human pregnancy, which is associated with down regulation of the immune system. We did not find any study addressing the impact of sex hormones on serum ox-LDL levels.…”

Section: Discussionsupporting

confidence: 84%

Serum heat shock protein 70 and oxidized LDL in patients with type 2 diabetes: does sex matter?

Nakhjavani

Morteza

Meysamie

et al. 2011

Cell Stress and Chaperones

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Several studies suggest that the response to various stressors differs between the sexes. We aimed to study serum HSP70 and levels of oxidized-LDL (ox-LDL) as markers of oxidative stress in men and women with type 2 diabetes. We quantified serum HSP70 and levels of ox-LDL in three cohorts; patients with newly diagnosed diabetes, patients with long-standing diabetes and normal controls. The cohort of patients with newly diagnosed diabetes was followed up for 3 months under glucoselowering therapy with metformin. Our findings showed that serum HSP70 level was increased in women with long-standing diabetes in comparison with men. HSP70 did not decrease after glucose lowering therapy in women with newly diagnosed diabetes, but it did decrease in men. There was no significant difference on ox-LDL between men and women in any of the studied cohorts. It decreased significantly in the cohort of patients with newly diagnosed diabetes after treatment, regardless of sex. There was no significant correlation between HSP70 and ox-LDL in any of the studied cohorts except among normal women. We suggest that diabetes induces an immune response and impairs cellular defense mechanisms against oxidative stress more commonly in women with type 2 diabetes than in men.

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Section: Discussionsupporting

confidence: 84%

Serum heat shock protein 70 and oxidized LDL in patients with type 2 diabetes: does sex matter?

Nakhjavani

Morteza

Meysamie

et al. 2011

Cell Stress and Chaperones

View full text Add to dashboard Cite

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“…Studies using a manufactured ELISA test generally report a significant variation of HSP-70 serum level in healthy donors ranging from less than 1 up to 14 ng/ml (Abe et al 2004;Adewoye et al 2005;Fehrenbach et al 2005;Genth-Zotz et al 2004;Molvarec et al 2007;Njemini et al 2003;Walsh et al 2001) and thus comparable to the levels that we found. Several physiological conditions may influence these levels, such as ageing (Rea et al 2001), pregnancy (Molvarec et al 2007) or physical exercise (Fehrenbach et al 2005;Walsh et al 2001). Additionally, pathologic situations such as acute infection or heart failure have been shown to increase the level of HSP-70 measured in the blood (Genth-Zotz et al 2004;Njemini et al 2003).…”

Section: Discussionsupporting

confidence: 86%

Elevated serum levels of heat shock protein 70 can be detected after radiofrequency ablation

Haen¹,

Gouttefangeas²,

Schmidt

et al. 2011

Cell Stress and Chaperones

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Due to their adjuvant effect and their ability to chaperone tumor-associated peptides, heat shock proteins constitute a potent alarm signal for the immune system and can lead to activation of anti-tumor T-cell immunity.Radiofrequency ablation has been reported to induce heat shock protein expression especially that of heat shock protein 70 in sublethally damaged tumor cells. In this study, we evaluated the release of heat shock protein 70 into the Sebastian P. Haen and Cécile Gouttefangeas contributed equally to this work.

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“…The pre-eclamptic patients and healthy pregnant women were matched on the basis of maternal age and gestational age at blood draw, and they were selected accordingly from the previously reported groups of 93 pre-eclamptic patients and 176 healthy pregnant women. 22,23 Exclusion criteria were multifetal gestation, chronic hypertension, diabetes mellitus, autoimmune disease, angiopathy, renal disorder, maternal or fetal infection and fetal congenital anomaly. The healthy non-pregnant women were consecutively selected in the early follicular phase of their menstrual cycle (between cycle days 3 and 5), and none of them received hormonal contraception.…”

Section: Study Patientsmentioning

confidence: 99%

Circulating angiogenic factors determined by electrochemiluminescence immunoassay in relation to the clinical features and laboratory parameters in women with pre-eclampsia

et al. 2010

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The purpose of this study was to determine whether increased serum soluble fms-like tyrosine kinase-1 (sFlt-1) and decreased placental growth factor (PlGF) levels in pre-eclampsia are related to the clinical features and laboratory parameters of the patients, including markers of inflammation, endothelial activation and injury, oxidative stress and trophoblast debris. A total of 54 pre-eclamptic patients, 58 healthy pregnant and 52 healthy non-pregnant women were involved in this case-control study. Serum sFlt-1 and PlGF levels were measured by electrochemiluminescence immunoassay. Serum levels of sFlt-1 and PlGF were significantly higher in pre-eclamptic patients and healthy pregnant women than in healthy non-pregnant women. In addition, pre-eclamptic patients had significantly higher sFlt-1 levels and significantly lower PlGF concentrations compared with healthy pregnant women. According to the subgroup analyses, sFlt-1 levels were significantly higher in severely pre-eclamptic patients than in those with mild pre-eclampsia, whereas pre-eclamptic patients with fetal growth restriction or preterm onset of the disease had significantly lower PlGF concentrations compared with those without intrauterine growth restriction or with a disease onset at term. In the pre-eclamptic group, there were significant positive correlations between serum sFlt-1 levels and systolic and diastolic blood pressure, serum levels of blood urea nitrogen and creatinine, as well as plasma levels of von Willebrand factor antigen, fibronectin and cell-free fetal DNA. Furthermore, serum PlGF concentrations of pre-eclamptic patients showed significant positive correlations with gestational age at disease onset and delivery, as well as with fetal birth weight, and significant inverse correlations with levels of blood urea nitrogen, creatinine and fibronectin. In conclusion, increased serum sFlt-1 and decreased PlGF levels are associated with blood pressure, renal and endothelial dysfunction, trophoblast deportation, as well as with a shorter duration of pregnancy, fetal growth restriction, the severity and preterm onset of the disease in pre-eclampsia. These findings indicate the central role of an angiogenic imbalance in the pathogenesis of this pregnancy-specific disorder.

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Serum heat shock protein 70 levels are decreased in normal human pregnancy

Cited by 46 publications

References 43 publications

Serum heat shock protein 70 and oxidized LDL in patients with type 2 diabetes: does sex matter?

Serum heat shock protein 70 and oxidized LDL in patients with type 2 diabetes: does sex matter?

Elevated serum levels of heat shock protein 70 can be detected after radiofrequency ablation

Circulating angiogenic factors determined by electrochemiluminescence immunoassay in relation to the clinical features and laboratory parameters in women with pre-eclampsia

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