Serum heart-type fatty acid-binding protein decreases and soluble isoform of suppression of tumorigenicity 2 increases significantly by long-term physical activity

Abstract

The aim of this prospective study was to investigate the influence of long-term physical activity on biomarkers for myocyte ischemia (heart-type fatty acid-binding protein, H-FABP), matrix remodelling/vascular stress (soluble isoform of suppression of tumorigenicity 2, sST2) and inflammation (soluble urokinase-type plasminogen activator receptor, suPAR). In this prospective observational study 109 subjects were recruited, 98 completed the study. Subjects were asked to perform exercise within the calculated training pulse for 8 months. The performance gain was measured/quantified by bicycle stress tests at the beginning and end of the observation period. Twenty-seven subjects with a performance gain <2.9% were excluded. suPAR, H-FABP and sST2 were measured in serum at baseline and after 2, 4 and 8 months by ELISA. We found a significant decrease in H-FABP (1.86 (0.86) to 1.29 (0.98) ng/mL; p<0.01) and a significant increase in sST2 levels (6126 (2759) to 6919 (3720) pg/mL; p=0.045) during the observation period of 8 months while there was no remarkable change in suPAR levels. We interpret the activity-induced decrease in H-FABP as sign of lower subclinical myocardial ischemia and better perfusion, probably due to a more economic metabolization and electrolyte balance. The increase in sST2 might reflect physiological sports-induced vascular stress. As H-FABP and sST2 play an important role in the pathomechanism of ischemic cardiomyopathy (iCMP) further studies should investigate the influence of regular physical activity on these biomarkers in a population of patients with iCMP.Trial registration number NCT02097199.

The Diagnostic and Therapeutic Value of Multimarker Analysis in Heart Failure. An Approach to Biomarker-Targeted Therapy

“…Intraindividual variation of serum marker is of further diagnostic limitation (155). Environmental circumstances, including height, are reported to have an influence on sST2, suPAR, H-FABP and GDF-15 levels (156). Furthermore, intensive physical exercise is reported to influence cardiac biomarkers (157,158).…”

Dynamic Changes of Heart Failure Biomarkers in Response to Parabolic Flight

“…Above all, similar to former investigations, we suspect a decrease in cardiac stress, which might be most probably based on the decrease in peripheral vascular resistance and heart rate observed in zero-gravity. These findings are supported by studies that show a significant increase in cardiac biomarkers with long-term physical activity [34]. Moreover, studies showing cardiac atrophy with an up-to-12% reduction in left ventricular mass in weightlessness underline the significant decrease in cardiac stress in zero gravity [3].…”

Suppression of tumorigenicity 2 after exercise: a systematic review

“…From title and abstract analysis, ten articles were included, and this set of articles was analyzed by the authors [24,29,[42][43][44][45][46][47][48][49]. Two studies were subsequently excluded, as they lacked ST2 assessment both before and after exercise [46,49].…”

“…Two studies were subsequently excluded, as they lacked ST2 assessment both before and after exercise [46,49]. Two other studies were excluded as they did not assess ST2 levels after an acute bout of exercise, analyzing its levels after a period of training [43,45]. A flowchart depicting the literature search method, as well as the resulting number of articles selected, is displayed in Figure 1.…”