Serum growth hormone and insulin in females without glucose intolerance

Danowski, T. S.; Tsai, Chien-Song; Morgan, Carl R.; Sieracki, Joseph C.; Alley, R. A.; Robbins, T.J.; Sabeh, G.; Sunder, J. H.

doi:10.1016/0026-0495(69)90056-0

Cited by 28 publications

(6 citation statements)

References 35 publications

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“…Only a few studies have been reported on the changes in somatotropin (HGH) levels with age in healthy adult subjects. In a population composed solely of females, Danowski et al (39) found no significant differences between the HGH levels in young and elderly adults. The intragroup variability, however, was very large.…”

Section: Discussionmentioning

confidence: 99%

Effects of an Oral Glucose Load on Serum Immunoreactive Insulin, Free Fatty Acid, Growth Hormone and Blood Sugar Levels in Young and Elderly Subjects*

Sandberg

Yoshimine²,

Maeda³

et al. 1973

J American Geriatrics Society

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In 29 healthy young adults and 22 ambulatory elderly subjects, a study was made of the effects of an oral glucose load on the levels of serum immunoreactive insulin (IRI), free fatty acids (FFA), growth hormone (HGH) and blood glucose. In the elderly, the pre‐load blood glucose and serum IRI levels were higher than in the younger group, reached the peak more gradually, and took longer to return to the baseline values. There was no significant difference in the serum FFA levels between the two groups until 3 hours after the glucose load, at which time the FFA values had returned to the fasting level in the young subjects but remained depressed in the elderly subjects. Serum HGH fasting levels in the elderly males were significantly higher than in the younger males and remained so at 1–2 hours after the glucose load. For the females, the numbers were too small and the intragroup variability too great to permit drawing conclusions. The total findings lend support to Dilman's hypothesis of a genetically programmed elevation of the hypothalamic threshold to feedback suppression, with age.

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Section: Discussionmentioning

confidence: 99%

Effects of an Oral Glucose Load on Serum Immunoreactive Insulin, Free Fatty Acid, Growth Hormone and Blood Sugar Levels in Young and Elderly Subjects*

Sandberg

Yoshimine²,

Maeda³

et al. 1973

J American Geriatrics Society

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“…per milliliter, p < 0.001). The values during and after exercise at 5,10,15,20,25,30,40, and 50 minutes were significantly higher in diabetics than in normals with p values between 0.05 and 0.005. Figure 2 shows the serum growth hormone values in the normal nonobese and obese groups and the diabetic nonobese and obese groups.…”

Section: Resultsmentioning

confidence: 79%

“…per minute for twenty minutes. Blood was taken before, during and after exercise at the following points of time: -30, -15, 0, 5,10,15,20,25,30,40,50, and 60 minutes.…”

Section: Methodsmentioning

confidence: 99%

Abnormal Serum Growth Hormone Response to Exercise in Maturity-onset Diabetics

Hansen¹

1973

Diabetes

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Serum growth hormone was studied during a mild exercise load of 350 kgm. per minute for twenty minutes in four groups of subjects: nonobese normal subjects, obese normal subjects, nonobese maturity-onset diabetics and obese maturity-onset diabetics.It was found that (1) the fasting pre-exercise serum growth hormone level was higher and the exercise response occurred earlier and was greater in diabetics than in normal subjects; (2) in the nonobese groups, the basal values and exercise responses in diabetics were significantly different from those of normal individuals. In the obese groups, the mean exercise response was higher in diabetics than in normals, but this difference was not significant; the basal values were identical in the two groups; and (3) the basal values and exercise responses were higher in nonobese diabetics than in obese diabetics. In normal subjects, the exercise responses were higher in the nonobese group than in the obese group. DIABETES 22:619-28, August, 1973.We have earlier studied serum growth hormone in young male patients with juvenile type diabetes. We found that the diurnal serum growth hormone level was three to four times higher in the diabetics than in male controls, and that the level fluctuated much more. 1 -2 We also found that fasting serum growth hormone and serum growth hormone responses to three exercise loads-450 kgm. per minute for twenty minutes, 450 kgm. per minute for forty minutes and 900 kgm. per minute for twenty minutes-were higher in the male diabetics than in controls. 3 " 5 Recently we demonstrated quite similar differences in the growth hormone patterns between young female patients with juvenile type diabetes and female controls, 6 although the serum growth hormone levels in

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“…The absence of any suppressive effect of quin gestanol upon the serum growth hormone levels recorded during the toler ance test is to be noted because medroxyprogesterone does decrease growth hormone levels when they are elevated as in acromegaly [21,30]. However, the growth hormone levels are already flat in obese persons with glucose intolerance [10] and perhaps neither medroxyprogesterone nor quingestanol can depress them further.…”

Section: Discussionmentioning

confidence: 99%

Effects of a Progestin, Quingestanol, in Older Diabetic Women

Danowski¹,

Wilson²,

Khurana³

et al. 1973

Horm Res

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Quingestanol acetate (17-α-ethynyl-19-nortestosterone acetate, 3-cyclopentylenol ether), a synthetic progestational steroid, was well tolerated at a dosage of 300 µg/day per os by 17 diabetic women who, with but one exception, were between 50 and 65 years of age and had ceased menstruating. Body weight, systolic and diastolic blood pressure, and the pulse rate were of the same orders of magnitude prior to and during the 12 months of quingestanol treatment. The diabetes mellitus was not affected but oscillometric readings at certain body points decreased during the year of treatment, probably reflecting the natural course of vascular disease in diabetic individuals.Despite changes in certain laboratory indices, i.e. slight increases of variable but usually short duration in serum sodium, chloride, total globulins and their α₂, β- and γ-fractions, SGOT, SGPT, LDH, FSH, chylomicrons, and blood platelets and the decreases in serum potassium, albumin, α₁-globulin, nonesterified fatty acids, β-lipoproteins, and plasma ll(OH)corticosteroids, most of the values remained within the ranges established for normal persons. One year of quingestanol therapy was associated with decreased first-day responses to metyrapone. This suggests, among other possibilities, that quingestanol inhibits the hypothalamic-pituitary controlled output of ACTH.All of the other items monitored during this course of quingestanol therapy remained unchanged.

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Serum growth hormone and insulin in females without glucose intolerance

Cited by 28 publications

References 35 publications

Effects of an Oral Glucose Load on Serum Immunoreactive Insulin, Free Fatty Acid, Growth Hormone and Blood Sugar Levels in Young and Elderly Subjects*

Effects of an Oral Glucose Load on Serum Immunoreactive Insulin, Free Fatty Acid, Growth Hormone and Blood Sugar Levels in Young and Elderly Subjects*

Abnormal Serum Growth Hormone Response to Exercise in Maturity-onset Diabetics

Effects of a Progestin, Quingestanol, in Older Diabetic Women

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