Abnormal Serum Growth Hormone Response to Exercise in Maturity-onset Diabetics

Abstract

Serum growth hormone was studied during a mild exercise load of 350 kgm. per minute for twenty minutes in four groups of subjects: nonobese normal subjects, obese normal subjects, nonobese maturity-onset diabetics and obese maturity-onset diabetics.It was found that (1) the fasting pre-exercise serum growth hormone level was higher and the exercise response occurred earlier and was greater in diabetics than in normal subjects; (2) in the nonobese groups, the basal values and exercise responses in diabetics were significantly different from those of normal individuals. In the obese groups, the mean exercise response was higher in diabetics than in normals, but this difference was not significant; the basal values were identical in the two groups; and (3) the basal values and exercise responses were higher in nonobese diabetics than in obese diabetics. In normal subjects, the exercise responses were higher in the nonobese group than in the obese group. DIABETES 22:619-28, August, 1973.We have earlier studied serum growth hormone in young male patients with juvenile type diabetes. We found that the diurnal serum growth hormone level was three to four times higher in the diabetics than in male controls, and that the level fluctuated much more. 1 -2 We also found that fasting serum growth hormone and serum growth hormone responses to three exercise loads-450 kgm. per minute for twenty minutes, 450 kgm. per minute for forty minutes and 900 kgm. per minute for twenty minutes-were higher in the male diabetics than in controls. 3 " 5 Recently we demonstrated quite similar differences in the growth hormone patterns between young female patients with juvenile type diabetes and female controls, 6 although the serum growth hormone levels in

Pathogenesis of Macrovascular Disease in the Human Diabetic

“…Sexual ateliotic dwarfs with monotropic deficiency of growth hormone are resistant to atherosclerosis, even though the incidence of diabetes is increased. 170 Carefully designed studies by Hansen et al 171 and others have shown increased growth hormone secretion in uncontrolled diabetics. The experimental work of Ledet on rabbit aortic medial cell cultures has shown a stimulation of cell proliferation in the presence of human growth hormone-containing serum from young diabetic subjects.…”

Reduced glucose incorporation to triglycerides following chronic exposure of human fat cells to growth hormone

“…In this con¬ nection the possible role of GH in diabetes mellitus is of interest. At least in poorly controlled diabetes, plasma GH is increased (Baird et al 1973;Prange Hansen 1973;Vigneri et al 1976) and this has been suggested to be of importance for the devel¬ opment of vascular complications (Baird et al 1973;Mérimée 1978). Furthermore, PFK activity, determined by enzyme assay as well as by measur¬ ing metabolic flow at this step, is reported to be impaired in diabetes (Galton & Wilson 1970a,b).…”

A Case of Abnormal Growth Hormone Secretion Possibly Caused by Low Somatomedin Production of Unknown Origin: Is The Unresponsiveness of GH Receptor Responsible For It?

“…GH hypersecretion induces high IGF-I levels and GH deficiency causes low IGF-I levels. However, low IGF-I levels in spite of normal or increased GH secretion are observed in such pathological conditions as protein-calorie malnutrition [1], liver diseases, uncontrolled diabetes mellitus [2] and Laron dwarfism [3]. In this paper, we present a case of low IGF-I production with GH hypersecretion which occurred in a patient with rheumatoid arthritis (RA) and diabetes mellitus (DM).…”