Serum glutathione S-transferase Pi as predictor of the outcome and acute kidney injury in premature newborns

Stojanović, Vesna; Barišić, Nenad; Radovanović, Tanja; Kovač, Nataša; Djuran, Jelena D.; Antic, A. Peco; Doronjski, Aleksandra

doi:10.1007/s00467-018-3910-x

Cited by 6 publications

(5 citation statements)

References 27 publications

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“…56 Another study showed that serum GST-pi levels within 6 hours of birth correlate with the occurrence and mortality of AKI in preterm neonates. 57 These findings suggest the potential of GST as a biomarker of nAKI.…”

Section: Glutathione S-transferasementioning

confidence: 85%

“…A study with 113 very low birth weight infants showed that urinary GST levels in AKI patients were 3.7-fold higher than those in non-AKI patients 57 . Another study showed that serum GST-pi levels within 6 hours of birth correlate with the occurrence and mortality of AKI in preterm neonates 58 . These findings suggest the potential of GST as a biomarker of nAKI.…”

Section: Gstmentioning

confidence: 99%

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Gut Microbiota and Neonatal Acute Kidney Injury

Yang,

He,

Dong

2024

Am J Perinatol

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Neonatal acute kidney injury has a complex pathogenesis and the gut microbiota is receiving increasing attention. Gut-kidney axis establishes a bidirectional link between gut microbiota and acute kidney injury. Promoting the study of gut microbiota and neonatal acute kidney injury will contribute to early detection and treatment of this disease. A series of promising biomarkers have emerged in recent years to predict neonatal acute kidney injury earlier than serum creatinine and urine output. However, comprehensive reports on these biomarkers are relatively scarce. In addition, the gut microbiota and biomarkers associated with neonatal acute kidney injury deserve further exploration. Herein, this review summarizes the relationship between gut microbiota and neonatal acute kidney injury biomarkers to deepen our understanding of the role of the gut-kidney axis in neonatal acute kidney injury and provide potential treatment options for neonatal acute kidney injury.

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Section: Glutathione S-transferasementioning

confidence: 85%

Section: Gstmentioning

confidence: 99%

Gut Microbiota and Neonatal Acute Kidney Injury

Yang,

He,

Dong

2024

Am J Perinatol

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“…[ 8 , 19 ] GST is considered to be one of the most promising biomarkers. [ 19 , 20 ] Some studies reported that after 4 h of HMP, the concentration of GST in perfusate no longer increased, indicating that GST mainly comes from cell damage caused by previous ischemia injury [ 11 ] In contrast, NGAL was found gradually up-regulated after ischemia. [ 10 ] IL-18 is a kind of cytokines produced by activation of the inflammatory and immune process during ischemia-reperfusion injury, which can cause cellular damage through various mechanisms [ 11 ] Several studies have shown that IL-18 is associated with DGF.…”

Section: Discussionmentioning

confidence: 99%

“…There are more than ten kinds of biomarkers reported internationally in the study of perfusate biomarkers [8,19] . GST is considered to be one of the most promising biomarkers [19,20] . Some studies reported that after 4 h of HMP, the concentration of GST in perfusate no longer increased, indicating that GST mainly comes from cell damage caused by previous ischemia injury [11] In contrast, NGAL was found gradually up-regulated after ischemia [10] .…”

Section: Discussionmentioning

confidence: 99%

Predictive value of hypothermic machine perfusion parameters combined perfusate biomarkers in deceased donor kidney transplantation

Qiao

Ding

Yang

et al. 2021

Chinese Medical Journal

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Background: Delayed graft function (DGF) is the main cause of renal function failure after kidney transplantation. This study aims at investigating the value of hypothermic machine perfusion (HMP) parameters combined with perfusate biomarkers on predicting DGF and the time of renal function recovery after deceased donor (DD) kidney transplantation. Methods: HMP parameters, perfusate biomarkers and baseline characteristics of 113 DD kidney transplantations from January 1, 2019 to August 31, 2019 in the First Affiliated Hospital of Xi’an Jiaotong University were retrospectively analyzed using univariate and multivariate logistic regression analysis. Results: In this study, the DGF incidence was 17.7% (20/113); The multivariate logistic regression results showed that terminal resistance (OR: 1.879, 95% CI 1.145–3.56) and glutathione S-transferase (GST)(OR = 1.62, 95% CI 1.23–2.46) were risk factors for DGF; The Cox model analysis indicated that terminal resistance was an independent hazard factor for renal function recovery time (HR = 0.823, 95% CI 0.735–0.981). The model combining terminal resistance and GST (AUC = 0.888, 95% CI: 0.842–0.933) significantly improved the DGF predictability compared with the use of terminal resistance (AUC = 0.756, 95% CI 0.693–0.818) or GST alone (AUC = 0.729, 95% CI 0.591–0.806). Conclusion: According to the factors analyzed in this study, the combination of HMP parameters and perfusate biomarkers displays a potent DGF predictive value.

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“…High levels of serum GST class Pi were detected in premature infants with severe perinatal asphyxia, compared to those with moderate asphyxia. Estimated high levels of serum GST Pi in the first 6 h after birth were associated with increased mortality and development of acute kidney failure in preterm neonates [ 228 ].…”

Section: General Considerations On Neonate’s Pharmacokineticsmentioning

confidence: 99%

Developmental Pharmacokinetics of Antibiotics Used in Neonatal ICU: Focus on Preterm Infants

et al. 2023

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Neonatal Infections are among the most common reasons for admission to the intensive care unit. Neonatal sepsis (NS) significantly contributes to mortality rates. Empiric antibiotic therapy of NS recommended by current international guidelines includes benzylpenicillin, ampicillin/amoxicillin, and aminoglycosides (gentamicin). The rise of antibacterial resistance precipitates the growth of the use of antibiotics of the Watch (second, third, and fourth generations of cephalosporines, carbapenems, macrolides, glycopeptides, rifamycins, fluoroquinolones) and Reserve groups (fifth generation of cephalosporines, oxazolidinones, lipoglycopeptides, fosfomycin), which are associated with a less clinical experience and higher risks of toxic reactions. A proper dosing regimen is essential for effective and safe antibiotic therapy, but its choice in neonates is complicated with high variability in the maturation of organ systems affecting drug absorption, distribution, metabolism, and excretion. Changes in antibiotic pharmacokinetic parameters result in altered efficacy and safety. Population pharmacokinetics can help to prognosis outcomes of antibiotic therapy, but it should be considered that the neonatal population is heterogeneous, and this heterogeneity is mainly determined by gestational and postnatal age. Preterm neonates are common in clinical practice, and due to the different physiology compared to the full terms, constitute a specific neonatal subpopulation. The objective of this review is to summarize the evidence about the developmental changes (specific for preterm and full-term infants, separately) of pharmacokinetic parameters of antibiotics used in neonatal intensive care units.

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Serum glutathione S-transferase Pi as predictor of the outcome and acute kidney injury in premature newborns

Abstract: The conclusion of our study is that high levels of serum GST Pi in the first 6 h after birth are associated with an increased mortality and development of AKI in prematurely born neonates.

Cited by 6 publications

References 27 publications

Gut Microbiota and Neonatal Acute Kidney Injury

Gut Microbiota and Neonatal Acute Kidney Injury

Predictive value of hypothermic machine perfusion parameters combined perfusate biomarkers in deceased donor kidney transplantation

Developmental Pharmacokinetics of Antibiotics Used in Neonatal ICU: Focus on Preterm Infants

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