Serum glucose and lipid levels in alloxan-induced diabetic rats following oral administration of &lt;I&gt;Aloe Barbadensis&lt;/I&gt; miller juice extract

Adesokan, AA; Akanji, Musbau Adewumi; Aderibigbe, AO

doi:10.4314/tjhc.v13i2.36691

Cited by 5 publications

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“…The antihyperglycemic effect of aloe vera at 500 mg /kg b.w dose was found to be more effect than 300 mg/kg b.w. This results are agree with another finding [28][29][30][31]. In this respect, Ayesha et al [32] reported that there are two possible explanations for the antidiabetic property of aloe barbadensis.…”

Section: Discussionsupporting

confidence: 93%

Hypoglycemic and Hepatoprotective Effects of Processed Aloe vera Gel in a Mice Model of Alloxan Induced Diabetes Mellitus

Siddiqui¹

2013

J Diabetes Metab

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Diabetes mellitus is a heterogeneous disease characterized by altered cellular metabolism. So many traditional herbs are being used by diabetic patients to control this disease. The aim of this study was to investigate the effects of aqueous extract of aloe vera leaves on hypoglycemic activity and hepatoprotective effects after alloxan injection in Swiss albino mice. In this study, aqueous leaf extract of aloe vera was carried out. Diabetes was induced in mice by alloxan monohydrate at dose of 150 mg/kg body weight injected intraperitoneally. Also alloxanized induced mice were administered with 300 and 500 mg/kg body weight orally daily of extract for a period of 21 days. At the end of the administration period, the mice were anaesthesized and dissect for the collection of blood and liver tissues. In diabetic mice, the SGOT, SGPT and bilirubin level as well as serum glucose levels were significantly increased (p<0.05) in comparison with the control groups. Diabetic mice group treated by extract at the dose of 300 and 500 mg/kg body weight orally significantly (p<0.05) reduced and normalised these biochemical parameters compared with alloxan induced diabetic group. Histopathological study also did show adverse alternation in the morphological architecture of the liver tissue. The results suggested that aqueous extract of aloe vera leaves possesses protective effect against alloxan induced diabetic mice. J ou rna l o f D ia be tes & M e ta bolism

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Section: Discussionsupporting

confidence: 93%

Hypoglycemic and Hepatoprotective Effects of Processed Aloe vera Gel in a Mice Model of Alloxan Induced Diabetes Mellitus

Siddiqui¹

2013

J Diabetes Metab

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“…Many medicinal plants have been confirmed to have hypoglycaemic properties. Some of them include Pterocarpus massupum (Indian Kino), Allium sativium (Garlic), Azadirachta indica (Neem), Carica papaya (unripe fruit), Trigonella foerum (Fenugreek), Ocimum santum (Tulsi), Aloe barbadensis miller (Adesokan et al,. 2006;Akinola, 2010).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Hypoglycaemic Efficacy of Aqueous Seed Extract of Aframomum melegueta in Alloxan-induced Diabetic Rats

Adesokan¹,

Akanji²,

Adewara³

2011

Sierra Leone j. biomed. res.

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The hypoglycaemic efficacy of aqueous seed extract of Aframomum melegueta was investigated in alloxaninduced diabetic rats. Twenty five albino rats (Rattus novergicus, average weight: 150g) were randomly divided into five groups of five (5) rats each. For the diabetic group, diabetes mellitus was induced by intraperitoneal injection of 5% solution of alloxan at a dose of 150 mg/kg body weight. Diabetes was confirmed 72 hours after alloxan injection if fasting blood glucose (FBG) was ≥ 10 mmol/l. Two control groups: non-diabetic (positive) and diabetic (negative) were administered tap water as vehicle solvent, throughout the duration of the experiment. The remaining three groups received 100 mg/kg of metformin, 200 and 400 mg/kg orally and aqueous seed extract of Aframomum melegueta respectively and simultaneously. Fasting blood glucose was evaluated daily. The results showed that oral administration of aqueous extract of A. melegueta to diabetic rats lowered blood glucose to normal level within 6 days of administration, while metformin took 14 days. There was no significant difference in the duration of lowering the blood glucose by the two doses of extract administered. In conclusion, oral administration of aqueous seed extract of Aframomum melegueta has potent hypoglycaemic activity in alloxanised diabetic rats.

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“…The latex contains a series of glycosides known as anthraquinones (Tyler, 1994). The hypoglycaemic property of this extract has earlier been shown (Adesokan et al, 2006). It is therefore imperative to investigate the effects of this medicinal plant on liver and kidney functions in diabetic rats so as to ascertain its safety.…”

Section: Introductionmentioning

confidence: 99%

“…A wide range of medicinal plants have been used by various cultures to treat diabetes mellitus because of their hypoglycaemic properties. Some of these medicinal plants include Vernomia amygdalina (Olagunju et al, 1998), unripe fruit of Carica papaya (Oloyede, 2005) and Aloe barbadensis (Adesokan et al, 2006). Aloe barbadensis (common name: Aloe vera) belongs to a class of plants called xeropids which have the ability to close their stomata completely to avoid loss of water (Artherton, 1997).…”

Section: Introductionmentioning

confidence: 99%

Kidney and Liver Function Parameters in Alloxan-Induced Diabetic Rats Treated with Aloe Barbadensis Juice Extract

A¹,

Oluwole²,

Babara³

2010

Sierra Leone j. biomed. res.

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Aloe barbadensis juice extract has been reported to possess hypoglycaemic property but the effects of its use on kidney and liver functions in diabetic animals have not been well investigated. This study investigated some biochemical parameters in the liver and kidney of alloxan-induced diabetic rats treated with Aloe barbadensis juice extract. Alloxan-induced diabetic rats were administered orally with Aloe barbadensis juice extract for seven days after which some biochemical indices in the serum, liver and kidney were measured and compared with the control. Serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea and creatinine of untreated diabetic group and treated diabetic groups were significantly elevated when compared with the normal control group with no significant changes in the levels of the enzymes in the liver and kidney. There were no significant changes (p>0.05) in the serum levels of Na+ and K+ in untreated diabetic group and treated diabetic groups when compared with the normal control rats which are not diabetic. These results suggest that administration of aqueous extract of Aloe barbadensis to diabetic rats did not have any adverse effect on the liver and kidney functions in rats showing that the extract is not toxic to man.

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Serum glucose and lipid levels in alloxan-induced diabetic rats following oral administration of <I>Aloe Barbadensis</I> miller juice extract

Cited by 5 publications

References 0 publications

Hypoglycemic and Hepatoprotective Effects of Processed Aloe vera Gel in a Mice Model of Alloxan Induced Diabetes Mellitus

Hypoglycemic and Hepatoprotective Effects of Processed Aloe vera Gel in a Mice Model of Alloxan Induced Diabetes Mellitus

Evaluation of Hypoglycaemic Efficacy of Aqueous Seed Extract of Aframomum melegueta in Alloxan-induced Diabetic Rats

Kidney and Liver Function Parameters in Alloxan-Induced Diabetic Rats Treated with Aloe Barbadensis Juice Extract

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