Serum Ghrelin Levels in Children With Celiac Disease

Selimoğlu, Mukadder Ayşe; Altınkaynak, Sevin; Ertekin, Vildan; Akçay, Fatih

doi:10.1097/00004836-200603000-00004

Cited by 19 publications

(14 citation statements)

References 19 publications

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“…Ghrelin levels were lower after 6 months under a gluten-free diet compared with the levels detected on admission. Ghrelin levels were still higher compared with that of healthy children (24), though treatment with a life-long gluten-free diet caused a marked improvement or complete restoration of the intestinal mucosa. The incomplete restoring of ghrelin levels after a gluten-free diet are explained by the fact that nutritional deficiencies do not completely normalize and an increase in resting metabolic rate occur in patients with coeliac disease even after gluten-free diet treatment (25,26).…”

Section: Inflammatory and Infectious Gastrointestinal Diseasesmentioning

confidence: 74%

Ghrelin in gastrointestinal diseases and disorders: A possible role in the pathophysiology and clinical implications (Review)

El‐Salhy

2009

Int J Mol Med

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Abstract. Ghrelin is a peptide hormone, which has been isolated from the stomach. It is localized mostly in endocrine cells in the oxyntic mucosa of the stomach. Ghrelin receptors are expressed equally in all parts of the gastrointestinal tract, with a similar level of expression in the mucosal and muscle layers. This peptide hormone has several functions, the most widely known is its growth hormone (GH)-releasing effect. Ghrelin plays an important role in regulating appetite, feeding and energy metabolism. It also plays a role in mediating immune response and inflammatory processes. Ghrelin stimulates gastric motility and emptying as well as motility in the small and large intestine. Ghrelin has been reported to be affected in several gastrointestinal diseases/disorders such as inflammatory bowel disease, coeliac disease, infectious diseases, functional disorders and diabetes gastroenteropathy. This indicates that ghrelin is involved in the pathophysiology of gastrointestinal diseases/disorders. Several studies have shown that ghrelin and its antagonist are a promising tool for treatment of several gastrointestinal diseases/disorders.

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Section: Inflammatory and Infectious Gastrointestinal Diseasesmentioning

confidence: 74%

Ghrelin in gastrointestinal diseases and disorders: A possible role in the pathophysiology and clinical implications (Review)

El‐Salhy

2009

Int J Mol Med

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“…In patient populations with malnutrition, IGF-I and IGFBP-3 levels were also found decreased but leptin is decreased as well in malnutrition [26] and ghrelin is high in anorexia nervosa, starvation and celiac disease [27,28]. Therefore we cannot compare our group of IDA children with the above mentioned groups.…”

Section: Discussionmentioning

confidence: 85%

Serum Levels of Ghrelin, Leptin, IGF-I, IGFBP-3, Insulin, Thyroid Hormones and Cortisol in Prepubertal Children with Iron Deficiency

İşgüven¹,

Arslanoğlu²,

Erol³

et al. 2007

Endocr J

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Abstract. The aim of the present study is to investigate possible alterations in ghrelin and other hormone levels related to appetite and somatic growth in children with iron deficiency anemia. Twenty-five patients and 25 healthy controls that were prepubertal and within normal limits regarding height and BMI standard deviation scores were recruited. Ghrelin, leptin, IGF-I, IGFBP-3, insulin, thyroid hormones and cortisol levels were studied. Ghrelin, insulin and IGF-I levels were significantly low in the study group (ghrelin 13.58 ± 16.32 vs. 35.39 ± 23.69 ng/ml, p<.001; insulin 3.41 ± 2.42 vs. 5.67 ± 1.09 mU/ml, p = .008 and IGF-I 126.94 ± 92.82 vs. 203 ± 105.1 ng/ml, p = .015). We concluded that low ghrelin and insulin levels might be causes of the appetite loss in iron deficiency and as a result of appetite loss and undernutrition as well as by direct effects they might be related with growth retardation, which could be also influenced by low IGF-I levels.

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“…Ghrelin has been reported to be abnormal in other gastrointestinal diseases such as inflammatory bowel diseases (29), coeliac disease (30)(31)(32)(33) and atrophic gastritis (34)(35)(36). Thus, ghrelin seems to be involved in the pathophysiology of gastrointestinal diseases/disorders.…”

Section: Discussionmentioning

confidence: 99%

Ghrelin in patients with irritable bowel syndrome

El‐Salhy

Lillebø²,

Reinemo³

et al. 2009

Int J Mol Med

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Abstract. General gastrointestinal dysmotility occurs in patients with irritable bowel syndrome (IBS). Ghrelin seems to play an important role in regulating gastrointestinal motility. The present study was undertaken, therefore, to establish the possible role of ghrelin in the pathophysiology of IBS. Thirty-seven patients with IBS (19 had IBS-constipation and 18 IBS-diarrhoea) were included in this study. Ten healthy volunteers served as controls. After overnight fast, blood samples were drawn from patients and controls, and a gastroduodenal endoscopy was performed. Biopsies were taken from oxyntic mucosa and duodenum. Ghrelin cell density was determined by computer image analysis after immunohistochemical staining of the tissues. Total and active ghrelin were detected in tissue extracts and plasma by commercially available RIA and ELISA Kits. The density of ghrelinimmunoreactive cells in the oxyntic mucosa was significantly lower in IBS-constipation and significantly higher in IBSdiarrhoea patients than healthy controls (P<0.0001 and <0.0001, respectively). There was no statistical difference in total or active ghrelin between IBS patients and controls, regarding tissue extracts or plasma. In order to compensate for the increase and decrease in the ghrelin cell density, the synthesis and release of ghrelin may be decreased and increased in IBS-diarrhoea and IBS-constipation patients, respectively. It has been speculated that this compensatory mechanism may be subjected from time to time to fatigue with the subsequent increased and decreased synthesis and release of ghrelin in IBS-diarrhoea and IBS-constipation with a subsequent intermittent diarrhoea or constipation seen in these patients, respectively.

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Serum Ghrelin Levels in Children With Celiac Disease

Abstract: Ghrelin is increased in childhood CD and is responsive to GFD. Further studies are needed to clarify the mechanism underlying its action in CD.

Cited by 19 publications

References 19 publications

Ghrelin in gastrointestinal diseases and disorders: A possible role in the pathophysiology and clinical implications (Review)

Ghrelin in gastrointestinal diseases and disorders: A possible role in the pathophysiology and clinical implications (Review)

Serum Levels of Ghrelin, Leptin, IGF-I, IGFBP-3, Insulin, Thyroid Hormones and Cortisol in Prepubertal Children with Iron Deficiency

Ghrelin in patients with irritable bowel syndrome

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