Serum Ghrelin, IGF-I and IGFBP-3 Levels In Children with Normal Variant Short Stature

Çamurdan, Mahmut Orhun; Bideci, Aysun; Demirel, Fatma; Cinaz, Peyami

doi:10.1507/endocrj.k05-167

Cited by 26 publications

(23 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In spite of using this assay we observed that ISS patients had a higher mean serum ghrelin level than controls and, moreover, 10 patients with ISS had ghrelin levels greater than 2 SD. This finding is in agreement with Camurdan et al [25], who recently investigated the role of ghrelin in normal variant short-statured patients. Ghrelin levels were higher in the short stature groups compared to controls.…”

Section: Discussionsupporting

confidence: 93%

“…Instead, higher ghrelin levels may reflect the orexigenic action of this peptide to increase weight in children with ISS. Camurdan et al [25] reported an inverse relationship between absolute values of IGF-I and ghrelin levels in short-statured patients with a mean age of 11 years. In contrast, we observed a positive correlation between ghrelin and IGF-I SDS only in females.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ghrelin Plasma Levels in Patients with Idiopathic Short Stature

et al. 2010

View full text Add to dashboard Cite

Background: Novel molecular insights have suggested that ghrelin may be involved in the pathogenesis of some forms of short stature. Recently, growth hormone secretagogue receptor (GHSR) mutations that segregate with short stature have been reported. Aim: To study plasma ghrelin levels in prepubertal patients with idiopathic short stature (ISS). Methods: Fasting total plasma ghrelin levels (radioimmunoassay) in 41 prepubertal patients with ISS (18 females, age 7.9 ± 0.5 years) compared with 42 age- and sex-matched controls (27 females, age 8.0 ± 0.3 years) with normal height. In a subset of 28 patients, the ghrelin receptor was sequenced. Results: ISS patients exhibited a higher level of ghrelin (1,458 ± 137 vs. 935 ± 55 pg/ml, p < 0.01) and similar IGF-I levels (–0.66 ± 1.29 vs. –0.32 ± 0.78 SDS) compared to controls. Ten patients with ISS had ghrelin levels greater than +2 SDS compared to controls. These patients did not differ in height, BMI or IGF-I SDS compared to ISS patients with ghrelin levels within the normal range. Molecular analysis of GHSR did not show any mutations, but showed some polymorphisms. Conclusion: These results suggest that in ISS patients, short stature does not appear to be frequently caused by abnormalities in ghrelin signaling.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Ghrelin Plasma Levels in Patients with Idiopathic Short Stature

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Our finding is interesting, because in conditions affecting appetite and growth adversely, ghrelin has been shown to increase [12,23]. Although our patient group was in acceptable limits regarding overall appetite and growth, and this was our intention in order to exclude the effects of body size on leptin levels, IDA is crudely a catabolic state.…”

Section: Discussionmentioning

confidence: 91%

“…height, weight and BMI). In a study among children with normal variant short stature ghrelin was increased and negatively correlated with height SDS in short children [23].…”

Section: Discussionmentioning

confidence: 94%

Serum Levels of Ghrelin, Leptin, IGF-I, IGFBP-3, Insulin, Thyroid Hormones and Cortisol in Prepubertal Children with Iron Deficiency

İşgüven¹,

Arslanoğlu²,

Erol³

et al. 2007

Endocr J

View full text Add to dashboard Cite

Abstract. The aim of the present study is to investigate possible alterations in ghrelin and other hormone levels related to appetite and somatic growth in children with iron deficiency anemia. Twenty-five patients and 25 healthy controls that were prepubertal and within normal limits regarding height and BMI standard deviation scores were recruited. Ghrelin, leptin, IGF-I, IGFBP-3, insulin, thyroid hormones and cortisol levels were studied. Ghrelin, insulin and IGF-I levels were significantly low in the study group (ghrelin 13.58 ± 16.32 vs. 35.39 ± 23.69 ng/ml, p<.001; insulin 3.41 ± 2.42 vs. 5.67 ± 1.09 mU/ml, p = .008 and IGF-I 126.94 ± 92.82 vs. 203 ± 105.1 ng/ml, p = .015). We concluded that low ghrelin and insulin levels might be causes of the appetite loss in iron deficiency and as a result of appetite loss and undernutrition as well as by direct effects they might be related with growth retardation, which could be also influenced by low IGF-I levels.

show abstract

“…Underweight children have been found to have elevated ghrelin levels, but only one study has shown low height SD score (SDS) as an independent determinant of elevated AG levels in children with idiopathic short stature (10,11). Recently, in several patients, however, a missense mutation resulting in a complete loss of GHSR constitutive activity has been implicated in short stature with dominant transmission (12).…”

mentioning

confidence: 99%

Total and Acylated Ghrelin Levels in Children With Poor Growth

et al. 2011

View full text Add to dashboard Cite

Ghrelin, an enteric hormone with potent appetite stimulating effects, also stimulates growth hormone release. We hypothesized that altered levels of total ghrelin (TG) or acylated ghrelin (AG) could affect growth by altering growth hormone secretion, subsequently affecting insulin-like growth factor-1 (IGF-1) generation or by altering appetite and food intake. After institutional review board approval, 52 children presenting for evaluation of chronic gastrointestinal symptoms (group 1), poor weight gain (group 2), or poor linear growth (group 3) were evaluated for fasting TG and AG levels in addition to their regular evaluation. Serum ghrelin, IGF-1, and prealbumin were compared between groups. No difference was observed for mean fasting TG between groups. However, mean fasting AG was highest in patients in group 2 (465 Ϯ 128 pg/mL) versus group 1 (176 Ϯ 37 pg/mL) and group 3 (190 Ϯ 34 pg/mL). IGF-1 was lowest in patients in group 2 despite similar prealbumin levels among the three groups. We conclude that serum AG levels are highest in children with isolated poor weight gain compared with children with short stature or chronic gastrointestinal symptoms, suggesting the possibility of resistance to AG in underweight children. Additional studies are needed to further clarify ghrelin's role in growth and appetite. (Pediatr Res 69: 517-521, 2011)

show abstract

Serum Ghrelin, IGF-I and IGFBP-3 Levels In Children with Normal Variant Short Stature

Cited by 26 publications

References 32 publications

Ghrelin Plasma Levels in Patients with Idiopathic Short Stature

Ghrelin Plasma Levels in Patients with Idiopathic Short Stature

Serum Levels of Ghrelin, Leptin, IGF-I, IGFBP-3, Insulin, Thyroid Hormones and Cortisol in Prepubertal Children with Iron Deficiency

Total and Acylated Ghrelin Levels in Children With Poor Growth

Contact Info

Product

Resources

About