Serum fucosylation changes in oral cancer and oral precancerous conditions

Shah, Manisha H.; Telang, S.D.; Raval, Gira; Shah, Pankaj; Patel, Prabhudas S.

doi:10.1002/cncr.23556

Cited by 61 publications

(65 citation statements)

References 31 publications

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“…Most of them belonged to 41-50 year age-group (36%), followed by 61-70 year age-group (34%). This finding was consistent with that of a study from Gujarat done by Shah et al, who reported that out of 130 patients of oral carcinoma, 94% were men, with a male to female ratio of 15.7:1 [15]. These high incidences of HNCs in males are mostly attributed to smoking in urban population and tobacco chewing and snuffing in rural India.…”

Section: Wwwjcdrnet Arunava Kali Et Al Significance Of Serum L-fusupporting

confidence: 92%

Significance of Serum L-fucose Glycoprotein as Cancer Biomarker in Head and Neck Malignancies without Distant Metastasis

Shetty

Bhandary

Kali

2013

JCDR

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Background: Head and neck neoplasia is a major form of cancer in India, accounting for 30% of all cancers which occur in males and 11% of cancers which occur in females. Elevated serum L-fucose glycoprotein levels have been reported to be associated with neoplastic conditions involving various sites. Therefore, monitoring serum/tissue L-fucose glycoprotein levels could be a promising approach for the early diagnosis and prognosis of head neck cancers.Aim: This study was carried out to determine the significance of serum L-fucose levels in head and neck malignancies. Settings and Design:This comparative study was carried out at a tertiary care hospital in South India. Material and Methods:Serum L-fucose glycoprotein levels were estimated in 50 patients with histopathologically confirmed head and neck malignancies and they were compared with those of 50 age-and sex-matched healthy controls. Statistical Analysis used:Student's t-test was used to compare L-fucose glycoprotein levels in study and control groups.Results: Most common site of the primary tumour in the current study was oral cavity, followed by larynx, hypopharynx and oropharynx respectively. Comparison of glycoprotein L-fucose in two groups showed more than a two-fold rise in serum fucose levels in cases as compared to the those in controls, with mean values of 11.33±7.39 and 4.74±1.55 mg% in cases and controls respectively. There was no relationship between serum fucose levels and age, sex and tumour differentiation. Conclusion:Serum glycoprotein L-fucose levels can be used as an effective biochemical indicator in conjunction with clinical diagnostic procedures in head and neck neoplasia and they may be useful for monitoring recurrences.

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Section: Wwwjcdrnet Arunava Kali Et Al Significance Of Serum L-fusupporting

confidence: 92%

Significance of Serum L-fucose Glycoprotein as Cancer Biomarker in Head and Neck Malignancies without Distant Metastasis

Shetty

Bhandary

Kali

2013

JCDR

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“…A subgroup of the cysts, including several IPMN, was observed here to contain hyperfucosylated N-linked glycans. Increased fucosylation has continued to be implicated in the progression of cancer (13)(14)(15)(16), including specifically pancreatic cancer (16,17). As such, hyperfucosylated N-glycans and glycoproteins have been targeted for quantitative label-free bottom-up glycoproteomic analysis.…”

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confidence: 99%

Glycomic and Proteomic Profiling of Pancreatic Cyst Fluids Identifies Hyperfucosylated Lactosamines on the N-linked Glycans of Overexpressed Glycoproteins

Mann

Goetz

House

et al. 2012

Molecular & Cellular Proteomics

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Pancreatic cancer is now the fourth leading cause of cancer deaths in the United States, and it is associated with an alarmingly low 5-year survival rate of 5%. However, a patient's prognosis is considerably improved when the malignant lesions are identified at an early stage of the disease and removed by surgical resection. Unfortunately, the absence of a practical screening strategy and clinical diagnostic test for identifying premalignant lesions within the pancreas often prevents early detection of pancreatic cancer. To aid in the development of a molecular screening system for early detection of the disease, we have performed glycomic and glycoproteomic profiling experiments on 21 pancreatic cyst fluid samples, including fluids from mucinous cystic neoplasms and intraductal papillary mucinous neoplasms, two types of mucinous cysts that are considered high risk to undergo malignant transformation. A total of 80 asparagine-linked (N-linked) glycans, including high mannose and complex structures, were identified. Of special interest was a series of complex N-linked glycans containing two to six fucose residues, located predominantly as substituents on ␤-lactosamine extensions. Following the observation of these "hyperfucosylated" glycans, bottom-up proteomics experiments utilizing a label-free quantitative approach were applied to the investigation of two sets of tryptically digested proteins derived from the cyst fluids: 1) all soluble proteins in the raw samples and 2) a subproteome of the soluble cyst fluid proteins that were selectively enriched for fucosylation through the use of surface-immobilized Aleuria aurantia lectin. A comparative analysis of these two proteomic data sets identified glycoproteins that were significantly enriched by lectin affinity. Several candidate glycoproteins that appear hyperfucosylated were identified, including triacylglycerol lipase and pancreatic ␣-amylase, which were 20-and 22-fold more abundant, respectively, following A. aurantia lectin enrichment. Molecular & Cellular Proteomics 11: 10.1074/mcp.M111.015792, 1-11, 2012.Pancreatic cancer is associated with a poor long term outcome with an actual 5-year survival rate of less than 5%. The absence of a practical screening strategy and clinical diagnostic test for identifying premalignant lesions within the pancreas prevents early detection of pancreatic cancer. Detection of early stage pancreatic cancer will likely result from novel clinical methods aimed at early tumor detection and molecular profiling of individuals at high risk for pancreatic carcinogenesis.High-resolution imaging techniques have increased the detection of small, organ-based lesions in the intra-abdominal cavity. Incidental cysts within the pancreas are detected in ϳ13% of patients undergoing cross-sectional imaging for nonspecific abdominal symptoms (1). Greater than 80% of these incidental cysts are non-neoplastic, so few carry malignant potential. Pancreatic cysts are divided into three broad pathologic entities: serous cystadenomas (SCA), 1 mucinous ...

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“…In this study, it was observed that TF, LAF and FF significantly increased in smoker groups. There is indirect evidence which indicate that, increased glycoprotein components levels are offset by increased fucosidase activity which is responsible for breaking down tissue and serum glycoproteins 31 .It is an important enzyme for fucose catabolism which is responsible for the altered fucosylation status of glycoproteins 33 . In the present study the activity of fucosidase may be altered by tobacco and smoke chemical components.…”

Section: Resultsmentioning

confidence: 99%