Serum free prolactin concentrations in patients with systemic lupus erythematosus are associated with lupus activity

Leaños‐Miranda, Alfredo; Cárdenas-Mondragón, Guadalupe

doi:10.1093/rheumatology/kei115

Cited by 59 publications

(33 citation statements)

References 28 publications

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“…To our knowledge, lupus is the only autoimmune disease where serum PRL levels have been measured discriminating the different isoforms of PRL [65]. This kind of analysis has outlined that levels of serum monomeric PRL (23 kDa) are higher in patients with active disease than in patients with nonactive disease, while there is a negative correlation between disease activity index and the percentage of the so-called "big big PRL" (>100 kDa), which is believed to have less biologic activity [65]. A recent study also identified a positive correlation between high PRL levels and disease damage in SLE [66].…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

Prolactin: A versatile regulator of inflammation and autoimmune pathology

Costanza¹,

Binart

Steinman

et al. 2015

Autoimmunity Reviews

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Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

Prolactin: A versatile regulator of inflammation and autoimmune pathology

Costanza¹,

Binart

Steinman

et al. 2015

Autoimmunity Reviews

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“…Prolactin may act as a cytokine and recent data show that PRL can break an autoreactive B-cells apoptosis and cause SLE in susceptible animals [25,26]. In humans, elevated serum PRL levels have been associated with active SLE [27] and immune cells from SLE patients produce more PRL than those from healthy individuals.…”

Section: Introductionmentioning

confidence: 99%

HLA class II, MICA and PRL gene polymorphisms: the common contribution to the systemic lupus erythematosus development in Czech population

et al. 2010

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ObjectiveThe genetic components contribute to the Systemic lupus erythematosus development. This study for the first time determined the distribution of the polymorphisms and linkage disequilibrium in HLA class II, MICA and PRL gene among patients suffering from SLE and healthy Czech individuals. Patients and Methods DNA ConclusionHLA class II-MICA combinations may increase/decrease a risk for SLE development.Multiple studies focusing on the ethnical differences as well as genetic-epigenetic relationships are necessary for better understanding SLE pathogenesis.

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“…In accordance, PRL levels have shown direct correlation with clinical and serological disease activity (16,(67)(68)(69). Results from several trials report also an association with neurological, renal and hematological involvement, serositis, enhanced anti-double-stranded DNA antibodies, and diminished complement (70,71). Furthermore, PRL bolsters the development of lupus-like phenotype in non-prone mice and exacerbated the disease in a lupus murine experimental study (72).…”

Section: Prl and Systemic Lupus Erythematosusmentioning

confidence: 99%

Prolactin and Autoimmunity

Orbach

Zandman‐Goddard

Boaz

et al. 2011

Clinic Rev Allerg Immunol

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The great asymmetry of autoimmune diseases between genders represents one of the most enigmatic observations among the mosaic of autoimmunity. Sex hormones are believed to play a crucial role on this dimorphism. The higher prevalence of autoimmunity among women at childbearing ages, disease onset/relapses during pregnancy, and post-partum are some of the arguments that support this hypothesis. Certainly, motherhood represents one of the most remarkable challenges for the immune system, which not only has to allow for the conceptus, but also has to deal with complex endocrine alterations. Hormonal homeostasis is known to exert a crucial influence in achieving a competent and healthy immune system. Prolactin (PRL) has a bioactive function acting as a hormone and a cytokine. It interferes with immune system modulation, mainly inhibiting the negative selection of autoreactive B lymphocytes. Likewise, hyperprolactinemia has been described in relation to the pathogenesis and activity of several autoimmune disorders. Dopamine is an effective inhibitor of PRL secretion due to either a direct influence on the hypophysis or stimulation of postsynaptic dopamine receptors in the hypothalamus, arousing the release of the PRL inhibitory factor. Hence, dopamine agonists have proven to offer clinical benefits among autoimmune patients and represent a promising therapy to be explored. In this review, we attempt to provide a critical overview of the link between PRL, autoimmune diseases, and motherhood.

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Serum free prolactin concentrations in patients with systemic lupus erythematosus are associated with lupus activity

Cited by 59 publications

References 28 publications

Prolactin: A versatile regulator of inflammation and autoimmune pathology

Prolactin: A versatile regulator of inflammation and autoimmune pathology

HLA class II, MICA and PRL gene polymorphisms: the common contribution to the systemic lupus erythematosus development in Czech population

Prolactin and Autoimmunity

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