Prolactin: A versatile regulator of inflammation and autoimmune pathology

Costanza, Massimo; Binart, Nadine; Steinman, Lawrence; Pedotti, Rosetta

doi:10.1016/j.autrev.2014.11.005

Cited by 70 publications

(64 citation statements)

References 113 publications

(138 reference statements)

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“…PRL is a versatile polypeptide produced mainly by the pituitary gland and partially in some extrapituitary tissues like immune cells 15,16 . PRL influences differentiation and maturation of T and B lymphocytes via its receptor expressed on several immune cells including their precursors (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…The regulation of pituitary PRL synthesis, the main source of serum PRL levels, is positively regulated by stress, exercise, circadian rhythms, the levels of estrogens and proinflammatory cytokines such as TNF-α and IL-6 (ref. 16,45 ). Thus elevated serum levels of PRL might reflect the inflammatory activity of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…All of these situations are associated with hyperprolactinemia. Prolactin (PRL) is an anterior pituitary hormone and besides its role in reproduction, it is part of the hypothalamus-pituitary-adrenal (HPA) axis and it is released after stressful events 15,16 . Prolactin is also produced by extra-pituitary sites including immune cells.…”

Section: Introductionmentioning

confidence: 99%

“…Prolactin is also produced by extra-pituitary sites including immune cells. The PRL receptor is thus expressed on many cell types including immune cells and keratinocytes and several PRL immunomodulatory functions have been described 16 . Experimentally, keratinocytes under PRL, synthesize chemokines with C-X-C and C-C motif which support Th1 and Th17 lymphocyte migration into psoriatic plaques 17,18 .…”

Section: Introductionmentioning

confidence: 99%

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Elevated serum prolactin levels as a marker of inflammatory arthritis in psoriasis vulgaris

Hušáková¹,

Lippert²,

Štolfa³

et al. 2015

BIOMED PAP

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a Background and Aims. Psoriasis vulgaris (PV) is complicated in up to 40% patients by the inflammatory joint disease psoriatic arthritis (PsA). Neither the aetiology of the arthritis nor specific laboratory markers for its disease activity have been clearly elucidated. Prolactin (PRL) acts as a cytokine with immunomodulatory functions and plays a role in skin and joint biology. The results on PRL however as a marker are unclear. The aim of this study was to confirm whether serum PRL levels reflect systemic complications of PV, like inflammatory joint disease and/or can serve as a marker of disease activity in both cases. Methods. A total of 70 patients with PV without arthritis and 40 patients suffering from PsA were included. In all patients, we determined skin disease activity according to the PASI index and in PsA, active disease assessed as swollen or tender joints. The control group included 27 age and sex matched healthy individuals. The concentration of PRL in the serum was measured by immunoradiometric assays. Results. The PRL serum levels were significantly increased in PsA patients (299.2±28.29 mIU/L) compared to PV only patients (201.4.2±11.72 mIU/L), P = 0.0003 and healthy individuals (198.2±15.31 mIU/L), P = 0.007. The serum PRL levels in PsA with active disease 336.8±42.50 (mIU/L) were higher than in PV and controls, P < 0.0001 and P = 0.002 respectively. In PV only patients, there was no correlation between PASI and PRL levels. Conclusion. Our results showed that PRL serum levels are a marker of active arthritis in PsA and reflects systemic complication rather than local skin activity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Elevated serum prolactin levels as a marker of inflammatory arthritis in psoriasis vulgaris

Hušáková¹,

Lippert²,

Štolfa³

et al. 2015

BIOMED PAP

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show abstract

“…They are distributed throughout the immune system and belong to the superfamily, which includes prolactin, growth hormone, leptin, IL-2, IL-3, IL-4, IL-6, IL-7, erythropoietin, and leukemia inhibitory factors [16-18]. Expression of the PRLR can be regulated by various stimuli, among which are the inflammatory mediators.…”

Section: Introductionmentioning

confidence: 99%

Short-Term Hyperprolactinemia Reduces the Expression of Purinergic P2X7 Receptors during Allergic Inflammatory Response of the Lungs

Ochoa-Amaya

Queiroz‐Hazarbassanov

Namazu

et al. 2018

Neuroimmunomodulation

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Purpose: We have previously shown that domperidone-induced short-term hyperprolactinemia reduces the lung’s allergic inflammatory response in an ovalbumin antigenic challenge model. Since purinergic receptor P2X7R activity leads to proinflammatory cytokine release and is possibly related to the pathogenesis of allergic respiratory conditions, the present study was designed to investigate a possible involvement of purinergic and prolactin receptors in this phenomenon. Methods: To induce hyperprolactinemia, domperidone was injected intraperitoneally in rats at a dose of 5.1 mg × kg^–1 per day for 5 days. P2X7 expression was evaluated by lung immunohistochemistry while prolactin receptor expression in bronchoalveolar lavage leukocytes was analyzed through flow cytometry. Results: Previous reports demonstrated that rats subjected to short-term hyperprolactinemia exhibited a decrease in leukocyte counts in bronchoalveolar lavage, especially granulocytes. Here, it is revealed that hyperprolactinemia promotes an increased expression of prolactin receptors in granulocytes. Also, increased expression of purinergic P2X7R observed in allergic animals was significantly reduced by hyperprolactinemia. Conclusions: Both purinergic and prolactin receptor expression changes occur during the anti-asthmatic effect of hyperprolactinemia.

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Impact of hyperprolactinemia in a patient with polyautoimmunity

Rojas

Rodríguez

Ramírez-Santana

et al. 2018

Clinical Case Reports

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Key Clinical MessageHyperprolactinemia has been proposed as a triggering factor for autoimmune diseases. The increased levels of prolactin could induce an abnormal immune response. Herein, we present a patient with hyperprolactinemia who developed polyautoimmunity. Patient's symptoms were associated with slightly raised levels of prolactin (20‐40 ng/mL) and administration of dopaminergic agonists.

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Prolactin: A versatile regulator of inflammation and autoimmune pathology

Cited by 70 publications

References 113 publications

Elevated serum prolactin levels as a marker of inflammatory arthritis in psoriasis vulgaris

Elevated serum prolactin levels as a marker of inflammatory arthritis in psoriasis vulgaris

Short-Term Hyperprolactinemia Reduces the Expression of Purinergic P2X7 Receptors during Allergic Inflammatory Response of the Lungs

Impact of hyperprolactinemia in a patient with polyautoimmunity

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