Serum Fetuin-A levels were increased and associated with insulin resistance in  women with polycystic ovary syndrome

Abstract

Background: Insulin resistance (IR) is a common characteristic in women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, in PCOS women, previous reports on changes in circulating Fetuin-A concentrations were inconsistent. Methods: A cross-sectional study was conducted, including 122 PCOS women and 85 healthy women. Circulating Fetuin-A levels were determined using an ELISA kit. Results: We found that circulating Fetuin-A concentration ranged from 196.6 to 418.2 µg/L for most normal women (95 %). Women with PCOS have higher circulating Fetuin-A levels than healthy women (437.9 ± 119.2 vs. 313.8 ± 60.4 μg/L; p <0.01). Serum Fetuin-A concentrations correlated positively with WHR, LDL-C, FIns, HOMA-IR, TEST and DHEA-S. Multivariate regression analysis showed that WHR, HOMA-IR and TEST were independent influencing factors of serum Fetuin-A. Binary logistic regression reaveled that serum Fetuin-A was associated with the .occurrence of PCOS. In addition, our ROC curve analysis found that the cutoff values for Fetuin-A to predict PCOS and IR were 366.3 and 412.6 µg/L. Conclusion: Blood Fetuin-A may be a useful biomarker for screening women with PCOS and IR.

Evaluation of the relationship between vitamin D3 level and sex hormones in women with PCOS

“…Also, the results of the current study did not agree with the results of the study of Al-Tikriti et al, (19) , which they showed no significant differences in the level of FSH in women with PCOS compared with healthy women. The results of the current study agree with the results of the study by Sak et al, (20) , which they founed high levels of FSH in women with PCOS compared to healthy women as a control group.…”

“…The results of the current study agree with many studies (20,26,25) that showed a significant increase in the level of LH in patients with PCOS. The reason for the high level of the hormone may be due to the increased sensitivity of the pituitary gland to LH-GnR, and this leads to an increase in the concentration of -Gonadotropin-releasing hormones GnRH or to changes in its secretion patterns LH mlU/ml 1111 (27) .…”

“…The results of the current study agree with the results of several last studies (20,25,30) that showed a significant increase in the level of testosterone in women with PCOS compared to healthy women as a control group. Androgens are usually derived from cholesterol in the ovaries and adrenal glands, and can be produced in muscle, liver, skin, and adipose tissue through the conversion of certain types of steroids (31) .…”

Evaluation of the relationship between Fetuin-A level and some biochemical variables in women with PCOS

“…The results of the current study agree with the results of several studies (22,19,23,24) that showed a significant increase in blood cholesterol level in women with PCOS Cholesterol mg/dl 1099 compared to healthy women as a control group. The cause of high blood cholesterol may be due to hyperinsulinemia and androgens.…”

“…It is evident from Table (2) that the level of LDL-C increased significantly (P≤0.05) among women with PCOS compared with the control group as shown in Figure (5). The results of the current study agree with the results of several last studies (22,19,23,24) who found higher levels of LDL in women with PCOS compared to healthy women. The reason for the high concentration of LDL-C is due to the fact that hyperlipidemia can lower the level of high-density protein and thus increase the level of low-density protein (30) .…”