Serum Fetuin a  Level: A New Possible Marker for Polycystic Ovarian Syndrome  in   Women with Infertility

Elsirgany, Sherif; Badawi, Hesham; El-Khayat, Zakaria; Bibers, Mamdouh; Hamdy, Manal; Hamdy, Ahmed; Salama, Sameh; Lotfy, Rehab; Alalfy, Mahmoud

doi:10.26502/ogr027

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are some studies demonstrated the association between PCOS and oxidative stress and hyperinsulinemia [ 23 - 25 ]. ElSirgany et al showed that the PCOS group had a significantly higher fetuin-A concentration than the control group and found a correlation between fetuin-A level and other hormones measured in PCOS women who especially sought fertility [ 26 ]. Aghilla et al also found similar results while the present study did not show any significant difference between the two groups in fetuin-A [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Investigating Fetuin-A and Paraoxonase-1 Activity as Markers in Polycystic Ovary Syndrome Based on Body Mass Index: A Prospective Case-Control Study

Gürbüz¹,

Tosun

Çebi

et al. 2021

Cureus

View full text Add to dashboard Cite

IntroductionPolycystic ovary syndrome (PCOS) may have an increased risk for the development of systemic and metabolic pathogenesis such as cardiovascular diseases, insulin resistance (IR), diabetes mellitus (DM) and dyslipidemia. However, there is no reliable marker to show the relation. Fetuin-A is an adipokine whereas paraoxonase-1 (PON-1) is a high-density lipoprotein-linked enzyme to demonstrate oxidative stress. This study aimed to evaluate serum fetuin-A and PON-1 levels in infertile PCOS women based on body mass index (BMI). MethodsA prospective case-control study in a university setting was designed. A total of 88 patients admitted to the Giresun University Faculty of Medicine Gynecology Clinic between February and April 2021 were included in the study. The subjects were divided as follows: PCOS-low-BMI (BMI≤25) vs. Controls-low-BMI (BMI≤25) and PCOS-high-BMI (BMI>25) vs. Controls-high-BMI (BMI>25). Those who had at least two criteria of the 2003 Rotterdam Consensus were diagnosed with PCOS. Serum fetuin-A and PON-1 levels were compared. ResultsThe mean levels of fetuin-A were not significantly different in the groups (p=0.955). Serum PON-1 levels were lower in the PCOS group (109.1±61.4 vs. 140.1±80.0; p=0.040), but it lost significance with adjusted values for covariants as age and BMI. Although PON-1 was not significantly different in the PCOS group of BMI<25 kg/m 2 subgroup, it was significantly lower in the PCOS group of BMI≥25 kg/m 2 subgroup (p=0.820 vs. p=0.048). ConclusionSerum fetuin-A activity did not differ with PCOS. Serum PON-1 might be a promising and research-worthy marker, especially for obese PCOS patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Investigating Fetuin-A and Paraoxonase-1 Activity as Markers in Polycystic Ovary Syndrome Based on Body Mass Index: A Prospective Case-Control Study

Gürbüz¹,

Tosun

Çebi

et al. 2021

Cureus

View full text Add to dashboard Cite

show abstract

“…There are many sources of vitamin D, some natural and some synthetic that can be obtained naturally from food (8) . It was found that exposure to sunlight is one of the main natural sources for obtaining the vitamin (9) . While foods rich in vitamin D2 and D3 such as milk, yogurt and vegetable ghee are important industrial sources for obtaining the vitamin (10) .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the relationship between vitamin D3 level and sex hormones in women with PCOS

Al-Zubaidi

Alsamarai

2022

ijhs

View full text Add to dashboard Cite

The current study included collection of 90 serum samples to assess the relationship between the level of vitamin D3 and some biochemical variables in women with polycystic ovarian syndrome. The samples were collected from external laboratories in Salah al-Din Governorate for the period from 10/29/2021 to 12/25/2021. 60 samples were taken for women with PCOS, and 30 samples were taken from the control group, their ages ranged between (18-40) years for healthy women and patients. Vitamin D3 level and some hormones concentrations (luteinizing hormone, follicle-stimulating hormone, and testosterone) were estimated in the blood serum of the study groups. The results of the current study showed that the level of vitamin D3 decreased significantly (P≤0.05) in women with PCOS compared to healthy women as a control group, the results showed a significant increase (P≤0.05) in the level of studding hormones (luteinizing hormone, follicle-stimulating hormone, and testosterone) in women with PCOS compared to healthy women as a control group.

show abstract

Evaluation of Serum Fetuin-A as A Possible Marker for Polycystic Ovarian Syndrome Among Iraqi Women; Case-control Study

Yasien,

Izzi

2023

acopen

View full text Add to dashboard Cite

Elevated levels of Fetuin-A, a protease inhibitor belonging to the cystatin family, have raised questions about its role in the pathogenesis of Polycystic Ovarian Syndrome (PCOS), the most prevalent endocrinopathy in reproductive-aged females. This case-control study, conducted in Iraq, aimed to assess changes in Fetuin-A levels among Iraqi women with PCOS. A convenient sample of 90 women, comprising 45 PCOS cases and 45 healthy controls, was enrolled. Fetuin-A levels were measured and found to be significantly higher in the PCOS group compared to controls. Additionally, significant positive correlations were observed between Fetuin-A levels and fasting plasma glucose, fasting serum insulin, insulin resistance, luteinizing hormone, and serum testosterone. Using a receiver operating characteristic curve, a cutoff point of 502.00 ng/mL was determined for predicting positive Fetuin-A levels, with a sensitivity and specificity of 84.4% and 73.3%, respectively. This study suggests that Fetuin-A could serve as a valuable marker for both screening and evaluating PCOS and its potential late consequences, including metabolic syndrome. Highlights: Elevated Fetuin-A Levels: This study reveals significantly higher Fetuin-A levels in PCOS, shedding light on its potential role in the pathogenesis of the syndrome. Correlations with Metabolic Factors: Positive correlations between Fetuin-A and key metabolic markers like fasting glucose, insulin resistance, and luteinizing hormone highlight its relevance in the context of PCOS and metabolic health. Screening Potential: The identified cutoff point for predicting positive Fetuin-A levels offers a promising tool for screening and evaluating PCOS and associated late consequences, particularly metabolic syndrome.

show abstract

Serum Fetuin a Level: A New Possible Marker for Polycystic Ovarian Syndrome in Women with Infertility

Cited by 3 publications

References 0 publications

Investigating Fetuin-A and Paraoxonase-1 Activity as Markers in Polycystic Ovary Syndrome Based on Body Mass Index: A Prospective Case-Control Study

Investigating Fetuin-A and Paraoxonase-1 Activity as Markers in Polycystic Ovary Syndrome Based on Body Mass Index: A Prospective Case-Control Study

Evaluation of the relationship between vitamin D3 level and sex hormones in women with PCOS

Evaluation of Serum Fetuin-A as A Possible Marker for Polycystic Ovarian Syndrome Among Iraqi Women; Case-control Study

Contact Info

Product

Resources

About