Serum eosinophil cationic protein in asthma: what does it mean?

Kips, Johan; Pauwels, Romain

doi:10.1046/j.1365-2222.1998.00194.x

Cited by 19 publications

(8 citation statements)

References 41 publications

(32 reference statements)

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“…However, only moderate correlations have been reported between the 2 components, 8 and this view is now being challenged by a model in which systemic inflammation plays an independent role in patients with asthma and other respiratory diseases. 3,9,10 This new hypothesis is supported by data from studies showing that systemic inflammation is not always reduced by inhaled corticosteroids 11,12 and that systemic therapies, such as leukotriene receptor antagonists, might be more effective in reducing systemic inflammatory markers. 13,14 Furthermore, biological treatments directed at blocking IL-5 effectively decrease the signs of systemic inflammation, as measured by B-Eos values, but does not change FENO values, 15 whereas anti-IL-13 treatment reduces FENO values without decreasing B-Eos values.…”

supporting

confidence: 56%

Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects

Malinovschi¹,

Fonseca²,

Jacinto³

et al. 2013

Journal of Allergy and Clinical Immunology

229

158

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Background: Fraction of exhaled nitric oxide (FENO) and blood eosinophil count (B-Eos) values, markers of local and systemic eosinophilic inflammation, respectively, are increased in asthmatic patients. Little is known about the relation of these markers to reported wheeze and asthma events in a random population sample. Objectives: We sought to determine the individual and independent values of B-Eos and FENO in relation to wheeze, asthma diagnosis, and asthma events in a cross-sectional study. 3 ) values rendered an adjusted odds ratio of 4.5 of having wheeze, 5.1 of having asthma, 5.4 for asthma attacks, and 2.9 for asthma-related ED visits compared with normal FENO (<25 ppb) and B-Eos (<300 cells/mm

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supporting

confidence: 56%

Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects

Malinovschi¹,

Fonseca²,

Jacinto³

et al. 2013

Journal of Allergy and Clinical Immunology

229

158

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“…The lack of a significant relationship observed in the children receiving inhaled steroids may suggest that the treatment could affect, to different extents, the degrees of airway reactivity and of eosinophil activation. This apparent discrepancy cannot be completely unexpected, since, although eosinophils are the most representative cell type of asthma, airway inflammation in this disease is a dynamic phenomenon to which different cell types mutually contribute [38] and inflammation is not the only factor responsible for BHR [39].…”

Section: Resultsmentioning

confidence: 99%

Exhaled nitric oxide, serum ECP and airway responsiveness in mild asthmatic children

Piacentini

Bodini

Costella³

et al. 2000

Eur Respir J

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The purpose of the present study was to assess the possible relationships between exhaled nitric oxide (ENO), a circulating marker of eosinophil activation, serum eosinophil cationic protein (SECP), level of airway responsiveness to methacholine and lung function in asthmatic children, as well as to compare these markers between children with and without inhaled steroid therapy.In a cross-sectional study ENO, SECP and bronchial hyperresponsiveness to methacholine were evaluated in a group of 57 asthmatic children (21 without and 36 with regulator inhaled steroid therapy; aged 6±13 yrs).ENO was significantly lower in steroid treated children (p<0.01). No significant differences between steroid treated and untreated children were observed for the provocative concentration of methacholine causing a 20% faill in forced expiratory volume in one second (FEV1; PC20), SECP and FEV1. In the whole study population significant increase correlations were observed between PC20 and SECP (r=-0.329, p=0.013) and between ENO and FEV1% of predicted (r=-0.348, p<0.01). In the group not receiving inhaled steroids the inverse relationship between PC20 and SECP was more evident (r=-0.581, p<0.001). In the steroid-treated group a significant inverse relationship was observed between ENO and FEV1 (r=-0.426, p=0.0011).The level of exhaled nitric oxide and the relationships between lung function, bronchial reactivity and markers of inflammation are different between steroidtreated and untreated asthmatic children. This has implications for the monitoring of asthma in childhood. The relationship between airway inflammation and airway responsiveness has been evaluated by different groups with contrasting results. Some authors [1±6] have found a strong relationship between inflammatory cells in the airway and the level of bronchial responsiveness while others failed to find such a correlation [7±11].Similarly, contrasting results have been found between serum markers of eosinophil activation, in particular serum eosinophil cationic protein (SECP), and the degree of bronchial responsiveness in asthmatic patients [12±15].Recently, the measurement of exhaled nitric oxide (ENO) has been proposed as a noninvasive means for assessing the degree of airway inflammation [16±18]. Some studies have evaluated the effect of treatment with inhaled steroids on the levels of ENO in asthmatic adults [19,20] and one study in children with acute asthma [21]. Furthermore, a few studies have evaluated the relationship of this parameter with the level of airway hyperresponsiveness with contrasting results [22±25].The purpose of the present study was to assess the possible relationship between ENO, a circulating marker of eosinophil activation SECP, level of bronchial hyperresponsiveness (BHR) to methacholine and lung function in asthmatic children, as well as to compare these markers between patients with and without inhaled steroid treatment. Material and methods Subjects and study designFifty-seven children with mild to moderate asthma, clinically st...

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“…However, measuring serum ECP may be more useful for monitoring disease activity in asthma. Currently, we have no reliable means of assessing airway inflammation in the clinical setting, although many agree that this would be a useful adjunct for clinicians managing patients with asthma ( 16). Serum ECP correlates with markers of airways inflammation in asthma and with other markers of disease activity such as symptom severity and blood eosinophil count.…”

Section: Discussionmentioning

confidence: 99%

Serum eosinophil cationic protein (ECP): reference values in healthy nonatopic children

Fitch

Brown

Schock³

et al. 1999

Allergy

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Serum eosinophil cationic protein in asthma: what does it mean?

Cited by 19 publications

References 41 publications

Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects

Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects

Exhaled nitric oxide, serum ECP and airway responsiveness in mild asthmatic children

Serum eosinophil cationic protein (ECP): reference values in healthy nonatopic children

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