Serum eosinophil cationic protein (ECP): reference values in healthy nonatopic children

Abstract

The 95th and 97.5 th percentiles for serum ECP for normal, nonatopic, nonasthmatic children (aged 1-15 years) were 19 and 20 microg/l, respectively. Age and exposure to parental ETS did not significantly alter serum ECP concentrations or the normal upper reference limits. Our data provide cutoff upper reference limits for normal children for use of serum ECP in a clinical or research setting.

Soluble immune receptor serum levels are associated with age, but not with clinical phenotype or disease severity in childhood atopic dermatitis

“…In contrast, ECP and tIgE serum levels revealed a positive correlation with patient age, respectively. As for tIgE, this steady increase is consistent with results of recent large‐scale epidemiological investigations, 31 whereas corresponding data on ECP have been shown to vary mainly depending on the investigated patient populations 32–34 …”

“…As for tIgE, this steady increase is consistent with results of recent large-scale epidemiological investigations, 31 whereas corresponding data on ECP have been shown to vary mainly depending on the investigated patient populations. [32][33][34]…”

Eosinophil cationic protein (ECP) in schoolchildren living in a mountainous area of Norway: a population‐based study of ECP as a tool for diagnosing asthma in children with reference values

“…Remes et al, using the 97.5th percentile as the upper reference limit, reported 24.7 µg/l in their control group of 68 nonatopic control subjects aged 7–12 years (11). Recently, Fitch et al published reference values of s‐ECP in 123 nonatopic, nonasthmatic children aged 1–15 years attending hospital for elective surgery, finding the 95th and 97.5th percentiles for s‐ECP to be 18.8 and 19.1 µg/l, respectively, corresponding well to the present results (31). Another study evaluated reference values of s‐ECP in smaller children under 4 years of age, finding 24.1 µg/l as the 95th percentile in the 2–4 years age group and 44.9 µg/l in the group under 2 years of age, but some atopic children were included (32).…”

Nocturnal enuresis and allergy

“…In our patients, elevated ECP levels demonstrated that allergies were active during the evaluation period. The mean ECP value of our enuretic group was significantly higher than that expected for the healthy population [11].…”