Soluble immune receptor serum levels are associated with age, but not with clinical phenotype or disease severity in childhood atopic dermatitis

Abstract

The current study provides evidence that sCD23, sCD25 and sCD30 serum levels are highly age-dependent. Serum concentrations of all investigated SIRs did not significantly correlate with disease severity in children with AD and were not differentially expressed in patients of different AD phenotypes. Therefore, we believe that the studied SIRs cannot be regarded as clinically useful biomarkers for the assessment of childhood AD.

Extrinsic and intrinsic types of atopic dermatitis

“…As expected with elevation of total serum IgE, extrinsic AD patients show high levels of Th2 cytokines, IL-4, IL-5 and IL-13, and intrinsic AD is linked with much lower levels of IL-4 and IL-13 [8]. Along with the elevation of IL-5 [26,27], eosinophil counts [11] and eosinophil cationic protein levels [18] are increased in the extrinsic type of AD. On the other hand, there was a report demonstrating that both extrinsic and intrinsic patients showed increased production of IL-5 and IL-13 [28].…”

“…According to their review paper, the frequency of intrinsic AD was 10-45%. More recently, the incidence of extrinsic AD and intrinsic AD were reported as follows: 73% vs 27% [18] and 63% vs 37% [15] in German children, 88% vs 12% in Hungarian adults [7], 78.2% vs 21.8% in Dutch patients from 13 to 37 years of age [4], and approximately 80% vs 20% in Korean [19]. These data are in accordance with the empirical knowledge that about 20% of AD patients show normal IgE levels and lack of sensitization towards environmental allergens.…”

Soluble IgE receptors—Elements of the IgE network

“…Elevated sCD23 levels have been found in association with allergic diseases, including asthma and atopic dermatitis [94–97]. There is some debate amongst allergists, however, as to whether sCD23 serum levels have a predictive value for the diagnosis of allergic reactions [98]. Clearly, further investigations are needed.…”

Advances in Assessing the Severity of Atopic Dermatitis

“…The serum levels of SIRs ,such as sCD14, sCD23, sCD25 and sCD30 have been reported to be associated with AD (Ott et al, 2010;El Mongy et al, 2008;Di Lorenzo er al., 2003;Hon et al, 2005;Furue et al, 1999). CD30 released by CD30+ cells, a member of the TNF receptor superfamily, is a costimulatory molecule expressed on activated T and B cells.…”

“…Although there were several researches indicated that serum sCD30 levels were significantly higher and correlated positively with the severity of AD as assessed by SCORAD, age and duration of the disease (El Mongy et al, 2008;Di Lorenzo et al, 2003). Ott H et al indicated that the serum level of sCD23, sCD25 and sCD30 were highly aged dependent and can not be regarded as useful biomarkers for assessment of childhood AD (Ott et al, 2010).…”