Serum Endocan Level and the Severity of Coronary Artery Disease

Köse, Murat; Emet, Samim; Akpınar, Timur Selçuk; Kocaaga, Mehmet; Cakmak, Ramazan; Akarsu, Murat; Yürüyen, Gülden; Arman, Yücel; Tükek, Tufan

doi:10.1177/0003319714548870

Cited by 87 publications

(90 citation statements)

References 15 publications

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“…We are committed to identifying biomarkers that can accurately reflect the severity and complexity of coronary vessel lesion in patients with CAD. An increasing number of biomarkers (e.g., hemoglobin A1, decoy receptor 3 and serum endocan) may serve as independent predictors for CAD and its severity [36][37][38]. Regarding miRNAs, a recent study by Gao et al [39] reported that circulating miR-145, as a VSMC-enriched miRNA that plays an important role in atherosclerosis, was negatively associated with the SYNTAX score and the severity of coronary artery lesion in CAD patients.…”

Section: Discussionmentioning

confidence: 99%

Plasma MicroRNA-126-5p is Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris

Zhao

Liu

et al. 2016

Cell Physiol Biochem

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Background: Coronary artery disease (CAD) is a major problem worldwide. As an endothelium-enriched microRNA (miRNA), miR-126 has been reported to serve as a potential biomarker of acute myocardial infarction. However, the relationship between miR-126 and the severity of CAD remains unknown. This study was designed to test whether circulating miR-126 levels are associated with the severity of CAD. Methods: The present study enrolled 40 patients who had risk factors for CAD without angiographically significant CAD, and 110 patients presenting with stable angina pectoris, who were validated left main coronary artery disease (LMCA) and/or multi-vessel disease by coronary angiography. The expression levels of plasma miR-126-5p from all enrolled subjects were estimated by quantitative real-time polymerase chain reaction (qRT-PCR). Then, the relationships between plasma miR-126-5p levels, number of diseased vessels and the corresponding Synergy between PCI with Taxus and Cardiac surgery (SYNTAX) score were analyzed. Results: The expression of circulating miR-126-5p was affected by some CAD risk factors including aging, dyslipidemia and DM. Furthermore, plasma miR-126-5p levels were significantly down-regulated in CAD patients with multi-vessel disease, higher SYNTAX score, rather than isolated LMCA and low SYNTAX score. Conclusion: Circulating miR-126-5p has emerged as a potential biomarker for complexity and severity of CAD in patients with stable angina pectoris.

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Section: Discussionmentioning

confidence: 99%

Plasma MicroRNA-126-5p is Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris

Zhao

Liu

et al. 2016

Cell Physiol Biochem

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“…The endocan levels were expressed as pg/mL. 22 Quantification of soluble tumor necrosis factor receptors 1 (sTNFR1) in serum samples was performed using ELISA kits (R&D Systems, Wiesbaden, Germany, Catalogue Numbers DY225, DY726, DY210, DY206, respectively) following the manufacturer's protocol. The detection limit was 10 pg/mL for all measurements.…”

Section: Methodsmentioning

confidence: 99%

Endocan Measurement for Active Behçet Disease

et al. 2017

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Objectives: This study aims to investigate the relationships between serum endocan, vascular endothelial growth factor (VEGF), and tumor necrosis factor-alpha (TNF-α) levels in active Behçet disease. Patients and methods: Forty patients with active Behçet disease (24 males, 16 females; mean age 37.6±8.7 years; range 20 to 50 years) and 40 healthy controls (22 males, 18 females; mean age 38.8±7.9 years; range 21 to 52 years) were included in this study. Both patient and control groups underwent a complete systemic and ophthalmic examination by the same specialist. Endocan, VEGF, and TNF-α levels were measured with an enzyme-linked immunosorbent assay kit in all subjects. Results: Serum endocan levels were 775.2±479.3 ng/mL and 275.8±145.8 ng/mL in the patient and control groups, respectively. VEGF levels were 1768.2±900.5 pg/mL and 980.2±135.3 pg/mL in the patient and control groups, respectively. TNF-α levels were 22.4±74.3 pg/mL-1 and 11.4±16.9 pg/mL-1 in the patient and control groups, respectively. There was a statistically significant difference between groups in terms of serum endocan, VEGF, and TNF-α levels. There was a significant positive correlation between serum endocan and VEGF levels in the patient group (r=0.630; p<0.001). Also, there was a significant positive correlation between serum endocan and TNF-α levels in the patient group (r=0.713; p<0.001). Conclusion: Serum endocan level may be a new marker in evaluation of both the prognosis and activity of Behçet disease.

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“…Furthermore, serum endocan levels were reported to be higher in patients with acute coronary syndrome compared to the control group. It was also reported that endocan can be a new marker that shows endothelial dysfunction [9]. Additionally, in dermatological diseases such as Behçet's disease and psoriasis, which are characterized by systemic inflammation, serum endocan levels are reported to be high.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Cardiovascular Risk Factors, Haematological and Biochemical Parameters, and Serum Endocan Levels in Patients with Lichen Planus

Özlü

Karadağ²,

Toprak³

et al. 2016

Dermatology

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Background and Objective: The current study aimed to evaluate cardiovascular risk factors, haematological and biochemical parameters, and serum endocan concentrations in lichen planus (LP) patients. Methods: This study was conducted with 86 cases, including 43 LP patients and 43 healthy controls. Cardiovascular risk factors, haematological and biochemical parameters, and endocan levels were evaluated. Results: The serum endocan concentrations of LP patients were not significantly different from those of the healthy controls (p > 0.05). There were no significant differences in the serum endocan levels according to classification by cardiovascular risk factors and smoking history (p > 0.05). In the LP group, white blood cell count, platelet distribution width and monocyte count/high-density lipoprotein cholesterol ratios were significantly higher when compared to the healthy controls (p < 0.05). The LP group had a lower mean platelet volume than the healthy controls (p < 0.05). Conclusions: Serum endocan levels did not change significantly in patients with LP, and there were significant differences in haematological and biochemical parameters.

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Serum Endocan Level and the Severity of Coronary Artery Disease

Cited by 87 publications

References 15 publications

Plasma MicroRNA-126-5p is Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris

Plasma MicroRNA-126-5p is Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris

Endocan Measurement for Active Behçet Disease

Evaluation of Cardiovascular Risk Factors, Haematological and Biochemical Parameters, and Serum Endocan Levels in Patients with Lichen Planus

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