Serum dipeptidyl peptidase 4 activity in children with type 1 diabetes mellitus

Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients

“…Similar to Iwabuchi et al (2013) [15] we found no correlation between enzyme activity in serum and BMI, although the BMI was slightly higher in the third tertile. The measurements of central obesity, i.e.…”

“…We could neither confirm or reject the correlation between serum DPP4 activity and HbA1c since Since T1DM is an autoimmune disease, we can hypothesise that elevated serum DPP4 activity might be attributable to variety of inflammatory reactions leading to pancreatic β cell destruction. Despite, two independent studies indicate that serum enzyme activity is not affected by islet-cell or glutamic acid decarboxylase antibodies [14,15]. Here we found significantly higher DPP4 activity in subjects with longer disease duration.…”

“…The group of patients with highest DPP4 activity had the lowest insulin sensitivity after controlling for all possible factors affecting DPP4 serum activity [15]. There are only several reports on serum DPP4 activity in T1DM, with one study reporting a significant correlation between serum DPP4 activity and HbA1c [24] and another suggesting the opposite [14].…”

“…Since T1DM is an immune mediated condition, the reports on elevated DPP4 activity in serum is not suprising [14]. The data from two independent studies suggest that DPP4 activity is higher in patients with T1DM compared to healthy controls but independently of islet-cell antibody status, C-peptide level, disease duration or glycated haemoglobin (HbA1c) level [14,15] However, they do report an inverse correlation with body mass index and insulin sensitivity [15]. Serum DPP4 activity is also higher in T2DM individuals with IR compared to those without [16].…”

Persons with latent autoimmune diabetes in adults express higher dipeptidyl peptidase-4 activity compared to persons with type 2 and type 1 diabetes

“…A fraction of soluble DPP-4 however, originates from the immune system cells which explain its altered abundance and the circulating activity in various immune mediated conditions [23] including T1DM [24]. Recent data suggest that DPP-4 activity is higher in persons with T1DM compared to healthy controls independently of islet-cell antibody status, C-peptide concentration, disease duration or HbA1c level [24] and in an inverse correlation with body mass index (BMI) and insulin sensitivity [24,25]. This is in accordance with our study results because patophysiology of LADA comprises an autoimmune component while its phenotype usually resembles T2DM.…”