Serum DHEA-S, Testosterone and Cortisol Levels in Female Patients with Schizophrenia

Bulut, Süleyman; Bulut, Serdar; Gündoğmuş, Ayse Gökçen; Aydemir, Çiğdem

doi:10.2174/1871530318666180212102128

Cited by 16 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings concerning female patients with schizophrenia versus controls differ from those of Bulut et al, who compared 32 pre-menopausal women with stable schizophrenia and 32 age-and sexmatched healthy controls. 39 However, although several investigators report higher levels in female patients versus controls, 40 other researchers obtained contrasting results. 41,42 The most important difference within the context of gender aspects of DHEA-physiology is, of course, the high levels of testosterone in males.…”

Section: Discussionmentioning

confidence: 99%

<p>Cortisol and DHEAS Related to Metabolic Syndrome in Patients with Schizophrenia</p>

Boiko¹,

Mednova²,

Kornetova³

et al. 2020

NDT

View full text Add to dashboard Cite

Background: Both dehydroepiandrosterone (DHEAS) and cortisol are secreted by the adrenal glands and may modulate metabolic syndrome (MetS), which often affects the health of patients with schizophrenia. The relationship between the serum levels of these hormones and MetS has not been established. Purpose: In this pilot study, we investigated the serum levels in schizophrenia patients with and without MetS and compared them with those in healthy volunteers. Patients and Methods: After obtaining informed consent, 110 patients with acute paranoid schizophrenia were recruited directly after admission to the Mental Health Research Institute. The control group consisted of 51 persons reported on questioning to be mentally and somatically healthy. Blood samples to prepare serum were drawn after an 8-h overnight fast during one of the first days of admission. Serum cortisol and DHEAS concentrations were quantified by enzyme-linked immunosorbent assay. Results: A total of 42 patients had MetS and 68 patients were without MetS. The cortisol blood level was significantly (p = 0.012) higher in schizophrenia patients without MetS in comparison to healthy controls, while patients with schizophrenia and a MetS have significantly (p = 0.014) lower DHEAS levels than healthy volunteers. These differences could, however, exclusively be attributed to female participants. Analysis of covariance adjusted for gender and age demonstrated a significant relationship between age and DHEAS levels (F = 9.512, р = 0.003). Conclusion: Lower DHEAS serum levels in relationship to MetS become evident in women, but not in men, and have age differences as a confounding factor.

show abstract

Section: Discussionmentioning

confidence: 99%

<p>Cortisol and DHEAS Related to Metabolic Syndrome in Patients with Schizophrenia</p>

Boiko¹,

Mednova²,

Kornetova³

et al. 2020

NDT

View full text Add to dashboard Cite

show abstract

“…Regarding women, it was recently reported ( 34 ) that there were statistically significantly higher levels of serum DHEA-S in schizophrenic women than in normal controls. No statistically significant difference was determined between the groups regarding serum testosterone and cortisol levels.…”

Section: Schizophrenia and Estrogenmentioning

confidence: 97%

Schizophrenia and Sex Hormones: What Is the Link?

Brzezinski-Sinai

Brzezinski

2020

Front. Psychiatry

View full text Add to dashboard Cite

The involvement of gonadal hormones in the pathogenesis of schizophrenia has long been suspected because the psychosis differs in women and men and the illness first makes its appearance shortly after puberty. Changes in sex hormones have been linked with increased vulnerability to mood disorders in women, while testosterone have been associated with increased sexual drive and aggressiveness in men as well as women. Some studies have found abnormal levels of estrogens and testosterone in schizophrenia patients, but the results have been inconsistent and sometimes attributed to the hyperprolactinemia effect of antipsychotics, which may interfere with sex hormones production. The purpose of this review is to present the current knowledge on the link between blood levels of sex-hormones in women during the various stages of the female reproductive life (i.e. puberty, menstrual cycle, pregnancy, contraception, and menopause) and the course of schizophrenia. We also attempt to optimize the clinical approach to women with schizophrenia at these different stages.

show abstract

“…Having analyzed the values in literature, several studies have concluded that female university students have higher levels of value [44,51], while high value orientations of male and female university students vary across the sample group [16,33,[52][53][54][55]. This research has found that female students have higher value levels, which may be due to the socio-cultural and demographic characteristics of the sample.…”

Section: Results Discussion and Recommendationsmentioning

confidence: 96%

Values within the Context of Postmodernity and Their Roles in Happiness: A Research on University Students

Coşkun¹

2017

ujer

View full text Add to dashboard Cite

The aim of the study is to explore the relation between values and happiness of the university students in the Context of Postmodernity. The research is a descriptive study in the screening model. The study was carried out with 376 students from the faculties of Physical Education and Sports, Education, Science and Letters, Business, Theology, Engineering, Forestry and Agriculture at Kahramanmaras Sutcu Imam University during the spring semester of 2016-2017 academic year. They were selected by convenience sampling method. 'Personal Information Form' and 'Values Scale', the original of which was created by Calp developed by the researcher and the 'Oxford Happiness Scale' developed by Dogan and Sapmaz were used as data collection tools. The research data were analyzed the descriptive and correlational statistics technique in terms of SPSS. The university students' values were found to be very high while their happiness levels were above the average; a positive and medium level relationship was identified between participants' values and happiness levels. Female students were found to have higher levels of values and happiness than male students. Students studying in the faculty of theology were determined to have the highest level of value and happiness.

show abstract

Serum DHEA-S, Testosterone and Cortisol Levels in Female Patients with Schizophrenia

Abstract: DHEA-S might be a potential biologic marker for schizophrenia because there is evidence of an association between DHEA-S and the pathophysiology of schizophrenia. However, further research with greater patient numbers is required to verify these findings.

Cited by 16 publications

References 0 publications

<p>Cortisol and DHEAS Related to Metabolic Syndrome in Patients with Schizophrenia</p>

<p>Cortisol and DHEAS Related to Metabolic Syndrome in Patients with Schizophrenia</p>

Schizophrenia and Sex Hormones: What Is the Link?

Values within the Context of Postmodernity and Their Roles in Happiness: A Research on University Students

Contact Info

Product

Resources

About