Serum DDT, age at menarche, and abnormal menstrual cycle length

Ouyang, Fengxiu; Perry, Melissa J.; Venners, Scott A.; Chen, C; Wang, B; Yang, Fan; Fang, Z; Zang, Tonghua; Wang, L; Xu, Xiping; Wang, X

doi:10.1136/oem.2005.020248

Cited by 130 publications

(85 citation statements)

References 33 publications

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“…Wolff et al (2008) do not find any change in timing of breast development in relation to serum DDE levels in girls in New York city (Table 5). Data on the timing of menarche (Table 6) after prepubertal exposure to DDE (DDT) are discrepant since it has been found to be early (Ouyang et al, 2005;Deng et al, 2012) or normal (Denham et al, 2005;Ozen et al, 2012). However, on account of the persistence of the insecticide in the body fluids, exposure earlier than in prepuberty cannot be excluded in these studies.…”

Section: Critical Windows Of Exposure To Endocrine Disrupters and Timmentioning

confidence: 80%

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

Parent

Franssen

Fudvoye

et al. 2015

Frontiers in Neuroendocrinology

155

140

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Puberty presents remarkable individual differences in timing reaching over 5 years in humans. We put emphasis on the two edges of the age distribution of pubertal signs in humans and point to an extended distribution towards earliness for initial pubertal stages and towards lateness for final pubertal stages. Such distortion of distribution is a recent phenomenon. This suggests changing environmental influences including the possible role of nutrition, stress and endocrine disruptors. Our ability to assess neuroendocrine effects and mechanisms is very limited in humans. Using the rodent as a model, we examine the impact of environmental factors on the individual variations in pubertal timing and the possible underlying mechanisms. The capacity of environmental factors to shape functioning of the neuroendocrine system is thought to be maximal during fetal and early postnatal life and possibly less important when approaching the time of onset of puberty.

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Section: Critical Windows Of Exposure To Endocrine Disrupters and Timmentioning

confidence: 80%

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

Parent

Franssen

Fudvoye

et al. 2015

Frontiers in Neuroendocrinology

155

140

View full text Add to dashboard Cite

show abstract

“…However recent studies have implicated endocrine disrupting chemicals in the environment as being responsible for this trend [19,[21][22][23] . Girls with high levels of lead in their blood had delayed menarche in US while exposure to dichlorodiphenyl trichloroethane (DDT), has been reported to decrease the age of menarche [35][36] . From this investigation, we established that the mean age of menarche in Trinidad is 11.71 years ±1.18.…”

Section: Resultsmentioning

confidence: 99%

Mean Age of Menarche in Trinidad and Its Relationship to Body Mass Index, Ethinicity and Mothers Age of Menarche

Uche-Nwachi¹,

Odekunle²,

Gray³

et al. 2007

OnLine J. of Biological Sciences

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Abstract:Menarche is the first menstrual period. It is the final event in the physical manifestation of gonadal development. A study in Europe found that the median age of menarche was 12 years and 11 months and that by the tenth year, 0.8% of the girls had their first menses, while the figure for the eleventh and twelfth years were 3.6 and 21.7% respectively. A Geneva study found that menarche was present in 50% at the age of 12.75 years. This study reported that, in the periods 1955-1980, the age of puberty has decreased by 0.5%, while the decrease between the periods 1965-1980 was 0.25%. Studies in the 70s and 80s found that African American girls were taller, heavier and maturing earlier than white girls of their age. Early menarche was observed in some of the girls by the age of 11 years, while all the girls were menstruating at the age of 15 years. Precocious puberty was defined as puberty before the age of eight years, while delayed puberty was defined as the absence of breast budding before the age of 14. However some pediatricians have concluded that the onset of breast development before the ages 7-8 years in white girls and between the ages of 6-7 years in African American girls may be part of the normal variation in the timing of puberty. It had been suspected that the decrease in the age of puberty is due to improved standard of living. However endocrine-disrupting chemicals from environmental pollutants are now seriously implicated as major factors in early puberty, while the ethnic factor has also been recognized. In this study, 489 students aged 15-17 selected from secondary schools from different areas of Trinidad were used. The data was collected through a questionnaire and the primary variable measured was the age of onset of menses. It also contained information on the ethnicity of the respondents. The heights and weights of the students were also measured. Results showed that, the mean age of menarche for Trinidadian girls was 11.71 years ±1.18. It also showed that the mean age for Blacks was 11.67±1.29, while that of Indians was 11.65±1.08. The mixed races' mean, was 11.87±1.09. No significant difference was found in the mean age of menarche between Blacks and East Indians. The result also showed a decrease in the age of menarche with increased BMI. The mean age of menarche of the mothers of the students sampled was 12.57 years, which is significantly higher that that of their daughters. This is consistent with recent findings, which reported that the mean age of menarche has been decreasing over the years in all societies.

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“…Сонымен, жүргізілген зерттеулерде [48][49][50], ДДТ және оның метаболиттерінің әсері ерте менархе және телархемен ассоциирленетіндігі көрсетілген. Мичиганда (АҚШ) 151 әйелден құралған топта [51], жатырында ДДЕ деңгейінің 15 μg/L дейін жоғарылауы менархенің орташа жасын 1 жылға қысқарғандығы анықталған.…”

Section: кіріспеunclassified