Serum DBH and Platelet MAO in Patients with Depressive Disorders

Honecker, Henning; Fähndrich, E; Coper, H.; Helmchen, Hanfried

doi:10.1055/s-2007-1019558

Cited by 8 publications

(5 citation statements)

References 22 publications

(33 reference statements)

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“…Our results confirm our previous observations (17) From our studies it is apparent that there is larger decrease of DBH activity in male patients in a depressive phase of affective illness compared with a similar group of female patients.…”

Section: Discussionsupporting

confidence: 92%

“…Strandman et al (16) confirmed the decrease of enzyme activity in a large group of patients (160), which was statistically significant for bipolar patients as compared with unipolar patients. Honecker et al (17) report a tendency of decreased DBH activity in the serum of patients with depression. Yu et al (12) also confirm the decreased DBH activity in the plasma of bipolar and unipolar patients, but after eliminating DBH antiinhibitors (Cu*, N-ethylmaleimide) from plasma during determination of the enzyme activity.…”

mentioning

confidence: 98%

See 1 more Smart Citation

Studies on biogenic amine metabolizing enzymes (DBH, COMT, MAO) and pathogenesis of affective illness

Pużyński¹,

Hauptmann²,

Załuska³

1983

Acta Psychiatr Scand

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On the basis of studies carried out with a group of 47 patients with endogenous depressive illness, lower plasma activity of dopamine-beta-hydroxylase (DBH) was found as compared with a control group (31 healthy persons). Lower DBH activity particularly characterized bipolar patients. Lowest DBH activity was found in patients with a family history of psychiatric disorders, in particular, affective illness (in comparison with the control group the difference was statistically significant, P less than 0.05). It was noticed, that in a period of remission or significant improvement the enzymatic activity increases, although in some cases the level of activity is still lower than in the control group. There was a correlation between activity of the enzyme and clinical course of the illness and susceptibility to antidepressive drugs. Most of the observed phenomena are related to male patients. On the basis of these studies and data supplied by corresponding literature, concerning in particular the effects of DBH inhibitors (fusaric acid, disulfiram), the authors consider that changes in DBH activity may play a role in the pathogenesis of depression and that DBH deserves further studies, also of genetic nature.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 98%

Studies on biogenic amine metabolizing enzymes (DBH, COMT, MAO) and pathogenesis of affective illness

Pużyński¹,

Hauptmann²,

Załuska³

1983

Acta Psychiatr Scand

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“…There have been, to our knowledge, no other reports of serum DBH activity in psychotic depression. Serum DBH activity in endogenous depression (mixed nonpsychotic and psychotic) has usually been found to be normal (Gershon, Lake, and Leckman 1979;Gershon et al 1980;Honecker et al 1981). We have now examined serum DBH activity in patients with schizoaffective depression, or schizoaffective mania, both affective and schizophrenic subtypes, and compared it to schizophrenia, mania, psychotic depression, and normal controls (table 1).…”

Section: Serum Dopamine-0-hydroxylase Activity and Catechol-o-methylmentioning

confidence: 98%

Biological Studies of Schizoaffective Disorders

Meltzer

Arora

Metz

1984

Schizophrenia Bulletin

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Biological studies of the relationships between the schizoaffective disorders, the affective disorders, and schizophrenia suggest that no simple reductionist model is supported by currently available data. Thus, both affective and schizoaffective patients but not schizophrenics, manifest abnormalities such as decreased platelet serotonin (5-HT) uptake, blunted clonidine-induced increase in serum growth hormone, shortened latency of rapid eye movement (REM) sleep, and increased REM density. However, there are some types of studies which show greater similarity between schizoaffective and schizophrenic patients than between schizoaffectives and affectives--e.g., increased cerebrospinal fluid (CSF) norepinephrine levels, increased platelet 5-HT content, and decreased prostaglandin E1-stimulated adenylate cyclase activity. Other types of studies show abnormalities common to all three groups of psychoses--e.g., eye tracking dysfunction, elevated CSF concentration of gamma-aminobutyric acid, and neuromuscular abnormalities. There are also abnormalities that have been reported to be present in only one type of the psychoses. Although none of these findings have been so unequivocally demonstrated that they can be considered to be firmly established, they do suggest that it is premature to conclude that the schizoaffective disorders are subtypes of the affective disorders. The possibility of a continuum model of the psychiatric psychoses of unknown etiology merits further consideration. Further biological studies of a broad range of psychiatric psychoses with inclusion of the schizoaffective categories appear indicated.

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“…However, the failure of serum DBH activity alone to be related to bipolar depression does not rule out the possibility that it may be of value in studies in this psychic disorder [14].…”

Section: Methodsmentioning

confidence: 99%

“…Assessment of the activity of MAO, COMT, and serum DBH was performed as described previously [5,7,11,14]. The measure of platelet MAO activity used in the present study was the maximum reaction velocity (V) towards tyramine [7].…”

Section: Methodsmentioning

confidence: 99%

Longitudinal Assessment of MAO-, COMT-, and DBHActivity in Patients with Bipolar Depression

Fähndrich¹,

Müller‐Oerlinghausen²,

Coper³

1982

Int Pharmacopsychiatry

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This study was carried out to determine whether the activity of regulatory enzymes for biogenic amines are state variables or trait variables for bipolar depression. The activity of MAO, COMT, and DBH in platelets, RBC and serum, respectively, was measured repeatedly in patients with bipolar depression and in matched control subjects. An increase in MAO activity was observed in patients compared to controls, while MAO activity was unrelated to the patient’s psychopathological state. COMT activity was higher in female patients than in female controls and was lower in male patients than in male controls, but it failed to be related to the psychopathological state of patients. Relevant differences in serum DBH activity failed to occur either between patients and controls, or in patients during different states of their illness. The findings suggest that the activity of MAO and COMT are trait variables for bipolar depression, while DBH activity is neither a state variable nor a trait variable. It is discussed why only longitudinal studies in contrast to conventional cross-sectional assessments allow a distinction between state and trait variables.

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Serum DBH and Platelet MAO in Patients with Depressive Disorders

Cited by 8 publications

References 22 publications

Studies on biogenic amine metabolizing enzymes (DBH, COMT, MAO) and pathogenesis of affective illness

Studies on biogenic amine metabolizing enzymes (DBH, COMT, MAO) and pathogenesis of affective illness

Biological Studies of Schizoaffective Disorders

Longitudinal Assessment of MAO-, COMT-, and DBHActivity in Patients with Bipolar Depression

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