Serum cytokines to predict systemic lupus erythematosus clinical and serological activity

Abstract

We aimed to explore the role of interleukin (IL)-6, interferon-gamma (IFNγ), IL-10, and tumor necrosis factor (TNF) as predictors of systemic lupus erythematosus (SLE) clinical and serological activity, and their correlation with the treatment received. We performed a retrospective analysis of 77 patients with SLE according to the 2012 Systemic Lupus International Collaborative Clinics (SLICC) criteria. The outcomes were serological activity (SA), active disease (AD), complete remission (CR), the low-disease activity state (LDAS), and immunosuppressive treatment.

FASlprgene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus

“…Unlike T cells, alterations in the B cell compartment in sle1 homo .lpr homo mice were limited to slightly reduced B1 and immature B cells (Fig 3C Given that several cytokines, such as IL-6, IL-10, IFN-and TNF-, have been implicated in SLE pathogenesis and associated with SLE clinical activity and serological changes [19], we next determined the serum levels of 36 cytokines in B6 and B6 congenic mice at the age of 3 months.…”

“…Given that several cytokines, such as IL-6, IL-10, IFN-ψ and TNF-α, have been implicated in SLE pathogenesis and associated with SLE clinical activity and serological changes [19], we next determined the serum levels of 36 cytokines in B6 and B6 congenic mice at the age of 3 months. Among the tested cytokines, serum levels of 32 cytokines were significantly higher in sle1 homo .lpr homo mice than those in B6 controls (Tab 2).…”

Significance of Interleukin 23 in Systemic Lupus Patients: Relation to Disease Activity and Damage Indices

“…Among these cytokines are IL6, IL10, interferon-gamma (IFNγ), and tumor necrosis factor (TNF), which have been found to be helpful in the assessment of SLE serological and clinical activity. 15 Another distinct one of these cytokines is the interleukin 23 (IL23), which is formed by monocytes and motivates the differentiation of T cells into Th17 cells. 16 …”

Usefulness of the hemogram as a measure of clinical and serological activity in systemic lupus erythematosus

“…Firstly, IL-6 has been found to be correlated with ESR, anti -dsDNA antibodies, disease activity, and anemia [ [19] , [20] , [21] , [22] , [23] , [24] ]. In parallel, TNF-alpha has been shown to be higher in patients with active disease, higher SLEDAI and hematological disease [ [25] , [26] , [27] ].…”