Usefulness of the hemogram as a measure of clinical and serological activity in systemic lupus erythematosus

Moreno-Torres, Víctor; Castejón, Raquel; Mellor‐Pita, Susana; Tutor-Ureta, Pablo; Campo, Pedro Durán-Del; Martínez-Urbistondo, María; Vázquez-Comendador, José; Gutiérrez-Rojas, Ángela; Rosado, Silvia; Vargas-Núñez, Juan-Antonio

doi:10.1016/j.jtauto.2022.100157

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…Among these, seven were excluded due to either a lack of PLR data or their nature as review articles. Consequently, a total of 15 studies, encompassing 1,522 patients diagnosed with SLE and 1,424 control subjects, fulfilled the predefined inclusion criteria [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] (Table 1 and Fig 1). Each study was evaluated on a scale of 1 to 10, resulting in quality ratings ranging from 6 to 8.…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

“…Several studies have investigated the relationship between the PLR and SLE; however, the findings are inconsistent and sometimes contradictory [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Some studies have reported elevated PLR in patients with SLE compared to healthy controls, whereas others have failed to show a significant difference.…”

Section: Introductionmentioning

confidence: 99%

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Platelet-to-lymphocyte ratio as a biomarker of systemic inflammation in systemic lupus erythematosus: A meta-analysis and systematic review

Lee,

Song

2024

PLoS ONE

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Objective The objective of this study was to evaluate the relationship between the platelet-to-lymphocyte ratio (PLR) and systemic lupus erythematosus (SLE). Additionally, the study aimed to establish an association between PLR and SLE disease activity, specifically lupus nephritis (LN). Methods We conducted a comprehensive search across Medline, Embase, and Cochrane databases to identify relevant articles. Subsequently, we performed meta-analyses to compare PLR between SLE patients and controls, as well as active and inactive SLE cases, along with LN and non-LN groups. Furthermore, a meta-analysis was conducted on correlation coefficients between PLR and various parameters in SLE patients, including the SLE Disease Activity Index (SLEDAI), C3, C4, anti-dsDNA, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Results In total, fifteen studies comprising 1,522 SLE patients and 1,424 controls were eligible for inclusion. The meta-analysis demonstrated a significant elevation of PLR in the SLE group compared to the control group (Standardized Mean Difference [SMD] = 0.604, 95% Confidence Interval [CI] = 0.299–0.909, p < 0.001). Upon stratification by ethnicity, an elevated PLR was observed in the SLE group among both Asian and Arab populations. Subgroup analysis based on sample size revealed consistently higher PLR in both small (n < 200) and large sample (n ≥ 200) SLE groups. Moreover, when considering disease activity, there was a noteworthy trend of increased PLR in the active disease group compared to the inactive group (SMD = 0.553, 95% CI = 0.000–1.106, p = 0.050). However, the meta-analysis did not demonstrate a significant distinction in PLR between the LN and non-LN groups. Notably, a positive association was established between PLR and SLEDAI (correlation coefficient = 0.325, 95% CI = 0.176–0.459, p < 0.001). Furthermore, PLR exhibited positive correlations with ESR, CRP, proteinuria, C3, and anti-dsDNA antibody levels. Conclusions The outcomes of this meta-analysis underscored the elevated PLR in SLE patients, suggesting its potential as a biomarker for gauging systemic inflammation in SLE. Additionally, PLR exhibited correlations with SLEDAI, as well as with key indicators such as ESR, CRP, proteinuria, C3, and anti-dsDNA antibody levels.

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Section: Studies Included In the Meta-analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Platelet-to-lymphocyte ratio as a biomarker of systemic inflammation in systemic lupus erythematosus: A meta-analysis and systematic review

Lee,

Song

2024

PLoS ONE

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Advances in the Study of Red Blood Cell Distribution Width in Rheumatic Diseases

魏

2023

ACM

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Blood Composite Scores in Patients with Systemic Lupus Erythematosus

Mercader-Salvans,

García-González,

Quevedo-Abeledo

et al. 2023

Biomedicines

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Complete blood count-derived ratios have been described as inflammatory biomarkers in several diseases. These hematological scores include the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index ([SIRI]; neutrophils × monocytes/lymphocytes). Our aim was to study how these biomarkers are related to disease expression in a large and well-characterized series of patients with systemic lupus erythematosus (SLE). A total of 284 SLE patients and 181 age- and sex-matched healthy controls were recruited. The NLR, MLR, PLR, and SIRI were calculated, and activity (SLEDAI-2K), severity (Katz), and damage index (SLICC-DI) scores were assessed in patients with SLE. Multivariable linear regression analysis was performed to study whether these scores differ between patients and controls and how they are related to clinical and laboratory features of the disease. Crude cell counts of neutrophils, monocytes, lymphocytes, and platelets were lower in SLE patients compared to controls. Despite this, NLR, MLR, and PRL, but not SIRI, were higher in SLE patients than in controls after multivariable analysis. However, the relationship between the different scores and disease characteristics was limited. Only the Katz severity index revealed a significant positive relationship with SIRI, NLR, and MLR after adjustment for covariates. Similarly, alternative complement cascade activation and low C3 were significantly associated with higher NLR, MLR, and PLR. In conclusion, although cytopenias are a common feature of patients with SLE, hematologic composite scores are independently higher in this population compared to controls. However, the relationship of these scores with the characteristics of the disease is scarce, with the relationship with the complement system being the most consistent.

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Usefulness of the hemogram as a measure of clinical and serological activity in systemic lupus erythematosus

Cited by 3 publications

References 30 publications

Platelet-to-lymphocyte ratio as a biomarker of systemic inflammation in systemic lupus erythematosus: A meta-analysis and systematic review

Platelet-to-lymphocyte ratio as a biomarker of systemic inflammation in systemic lupus erythematosus: A meta-analysis and systematic review

Advances in the Study of Red Blood Cell Distribution Width in Rheumatic Diseases

Blood Composite Scores in Patients with Systemic Lupus Erythematosus

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