Serum Cystatin C Concentration Compared with Other Markers of Glomerular Filtration Rate in the Old Old

Noortgate, Nele J. Van Den; Janssens, Wim; Delanghe, Joris; Afschrift, Marcel; Lameire, Norbert

doi:10.1046/j.1532-5415.2002.50317.x

Cited by 100 publications

(58 citation statements)

References 23 publications

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“…Van Den Noortgate et al evaluated and compared the concentration of serum Cys-C with markers of GFR in 48 elderly patients, including 25 patients aged 85 years or older. The results of these authors revealed that serum Cys-C, serum Cre, urinary CrCl, the Cockcroft-Gault formula and the MDRD formula were comparable markers of renal function in the overall older population (22). In a recent review, Van Pottelbergh et al indicated that evidence regarding the use of serum levels of Cys-C in elderly patients is limited (6).…”

Section: Discussionmentioning

confidence: 99%

Serum levels of cystatin C in elderly lung cancer patients

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Serum levels of cystatin C in elderly lung cancer patients

et al. 2011

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“…A simple comparison of correlations is not, however, statistically sufficient to confirm that CysC is superior to creatinine. CysC could be a more sensitive marker than creatinine to investigate for moderate reductions in GFR in the elderly (69-92 years old) (185,186), although the results reported are inconclusive (98,99).…”

Section: The Elderlymentioning

confidence: 99%

Cystatin C: current position and future prospects

Séronie-Vivien

Delanaye

Piéroni³

et al. 2008

Clinical Chemistry and Laboratory Medicine

163

145

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Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. This review summarises current knowledge about the physiology of cystatin C and about its use as a renal marker, either alone or in equations developed to estimate the glomerular filtration rate. This paper also reviews recent data about the other applications of cystatin C, particularly in cardiology, oncology and clinical pharmacology. Clin Chem Lab Med 2008;46:1664-86.

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“…6 As a consequence, clinical guidelines by the National Kidney Foundation (NKF) 7 and others 8 call for screening for CKD using either the Cockcroft-Gault (CG) 9 or Modified Diet in Renal Disease (MDRD) 10 equations, which can be easily calculated, instead of serum creatinine. Of the two, the Modified Diet in Renal Disease (MDRD) equation appears to be more accurate for older patients, [11][12][13][14][15] and is recommended by the NKF.…”

Section: Introductionmentioning

confidence: 99%

Recognition and Management of Chronic Kidney Disease in an Elderly Ambulatory Population

et al. 2008

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BACKGROUND: Chronic kidney disease (CKD) is a growing problem among the elderly. Early detection is considered essential to ensure proper treatment and to avoid drug toxicity, but detection is challenging because elderly patients with CKD often have normal serum creatinine levels. We hypothesized that most cases of CKD in the elderly would go undetected, resulting in inappropriate prescribing. OBJECTIVE:To determine whether recognition of CKD is associated with more appropriate treatment DESIGN: Retrospective chart review PARTICIPANTS: All patients aged ≥65 years with a measured serum creatinine in the past 3 years at 2 inner city academic health centers.MEASUREMENTS: Estimated glomerular filtration rate (eGFR) calculated using the Modified Diet in Renal Disease equation, and for patients with eGFR<60, documentation of CKD by the provider, diagnostic testing, nephrology referral and prescription of appropriate or contraindicated medications. RESULTS:Of 814 patients with sufficient information to estimate eGFR, 192 (33%) had moderate (eGFR< 60 mL/min) and 5% had severe (eGFR<30 mL/min) CKD. Providers identified 38% of moderate and 87% of severe CKD. Compared to patients without recognized CKD, recognized patients were more likely to receive an ACE/ARB (80% vs 61%, p=.001), a nephrology referral (58% vs 2%, p<.0001), or urine testing (75% vs 47%, p<.0001), and less likely to receive contraindicated medications (26% vs 40%, p=.013). CONCLUSIONS:Physicians frequently fail to diagnose CKD in the elderly, leading to inappropriate treatment. Efforts should focus on helping physicians better identify patients with low GFR.

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Serum Cystatin C Concentration Compared with Other Markers of Glomerular Filtration Rate in the Old Old

Cited by 100 publications

References 23 publications

Serum levels of cystatin C in elderly lung cancer patients

Serum levels of cystatin C in elderly lung cancer patients

Cystatin C: current position and future prospects

Recognition and Management of Chronic Kidney Disease in an Elderly Ambulatory Population

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